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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
extended conformation
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "extended conformation" in MCE Product Catalog:
3
Research Areas:
RG3039 (PF-06687859) is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC50 of 4.2 nM against hDcpS. RG3039 inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 extends survival and improves function in spinal muscular atrophy mice. RG3039 is applicable to research related to spinal muscular atrophy .
Cat. No.: HY-100838A
CAS No.: 117857-93-9
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L-CCG-I is an extended isomer of conformationally restricted glutamate analog. L-CCG-I also is a potent agonist for mGluR2 with an EC50 value of 0.3 nM. L-CCG-I can be used for the research of mGluR family .
Cat. No.: HY-120622
CAS No.: 225521-80-2
BMS-243117 is a potent, and selective benzothiazole based p56 Lck inhibitor with an IC50 of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC50 of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck .
Cat. No.: HY-187623
CAS No.: 149607-21-6
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U 92163 is an HIV-2 protease inhibitor. It is a synthetic peptidomimetic transition-state analog. U 92163 binds in an extended conformation along the length of the enzyme's binding cleft, and forms hydrogen bonds with the catalytic aspartate pair and other protease residues to block enzyme activity. U 92163 can be used in research on acquired immunodeficiency syndrome (AIDS) .
Cat. No.: HY-102020A
CAS No.: 1466525-84-7
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RG3039 hydrochloride is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC50 of 4.2 nM against hDcpS. RG3039 hydrochloride inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 hydrochloride extends survival and improves function in spinal muscular atrophy mice. RG3039 hydrochloride is applicable to research related to spinal muscular atrophy .
Cat. No.: HY-131642
CAS No.: 53861-57-7
Synonyms: H-Gla-OH
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L-γ-Carboxyglutamic acid (H-Gla-OH) is a mGluR2 antagonist with an IC50 of 102 μM. L-γ-Carboxyglutamic acid binds to the mGluR2 receptor site via the overlapping extended amino acid conformation of its amino and carboxyl groups with glutamic acid, and its additional acidic group locates in a restricted region, thereby blocking the full activation of the receptor. L-γ-Carboxyglutamic acid can be used for the research of neurological disorders .
Cat. No.: HY-189295
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Aurora B/RET-IN-1 is a dual RET and Aurora B inhibitor with human IC50 values of 78 nM and 24 nM, respectively. Aurora B/RET-IN-1 binds the DFG-out conformation of RET as a type II inhibitor and extends into the allosteric pocket. Aurora B/RET-IN-1 inhibits Aurora B kinase activity. Aurora B/RET-IN-1 inhibits RET and Aurora B signaling pathways. Aurora B/RET-IN-1 can be used for research on non-small cell lung cancer .
Cat. No.: HY-102020R
CAS No.: 1005504-62-0
Synonyms: PF-06687859 (Standard)
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Research Areas:
RG3039 (Standard) is the analytical standard of RG3039 (HY-102020). This product is intended for research and analytical applications. RG3039 (PF-06687859) is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC50 of 4.2 nM against hDcpS. RG3039 inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 extends survival and improves function in spinal muscular atrophy mice. RG3039 is applicable to research related to spinal muscular atrophy .
Cat. No.: HY-184284
CAS No.: 2798832-23-0
Target:
Penicillin-binding protein (PBP) Bacterial DNA Alkylator/Crosslinker Reactive Oxygen Species (ROS)
Research Areas:
Antibacterial agent 351 is a broad-spectrum antibacterial agent. Antibacterial agent 351 binds to the allosteric site of PBP2a, induces conformational changes, and reduces the level of PBP2a in MRSA. Antibacterial agent 351 acts as a DNA intercalator to interfere with bacterial DNA function. Antibacterial agent 351 disrupts bacterial redox homeostasis via excessive production of ROS and RNS, depletes intracellular GSH, induces lipid peroxidation, and triggers bacterial cell death. Antibacterial agent 351 enhances the activity of Metronidazole (HY-B0318) against anaerobic bacteria and extends the antibacterial spectrum of Metronidazole to aerobic bacteria. Antibacterial agent 351 can be used in the research of bacterial infections (including MRSA infections) .
Cat. No.: HY-P1609
CAS No.: 105116-61-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
