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Results for "

glucose transporter

" in MedChemExpress (MCE) Product Catalog:

By Targets:	GLUT (37) SGLT (8) Acetyl-CoA Carboxylase (2) Akt (11) Amylases (2) Antibiotic (4) Apoptosis (12) Autophagy (7) Bacterial (4) Beclin1 (3) Biochemical Assay Reagents (2) Caspase (1) Dipeptidyl Peptidase (2) Disulfidptosis (3) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (4) Drug Derivative (1) EGFR (2) Endogenous Metabolite (3) Fluorescent Dye (2) FXR (2) GLP Receptor (2) HCV (4) HIF/HIF Prolyl-Hydroxylase (3) Influenza Virus (1) Insulin Receptor (3) JNK (3) Lactate Dehydrogenase (1) Mitochondrial Metabolism (1) MMP (3) mRNA (1) mTOR (1) NF-κB (5) NKCC (1) P-glycoprotein (2) p38 MAPK (2) Parasite (1) Phosphatase (2) PI3K (2) PKC (1) Reactive Oxygen Species (ROS) (1) Reference Standards (12) Sirtuin (2) Sodium Channel (1) TNF Receptor (2) Toll-like Receptor (TLR) (1) Topoisomerase (2) URAT1 (1) VEGFR (3)
By Research Areas:	Cancer (32) Cardiovascular Disease (6) Endocrinology (3) Infection (9) Inflammation/Immunology (10) Metabolic Disease (33) Neurological Disease (4)
Click Chemistry:	Azide (1)
Oligonucleotides:	Transcription Factors (1) mRNA (1)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: GLUT Glucose-6-Phosphate Isomerase (GPI) SGLT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13753

Streptozotocin Maximum Cited Publications 137 Publications Verification Streptozocin; NSC-85998; U 9889	DNA/RNA Synthesis DNA Alkylator/Crosslinker Autophagy Bacterial Antibiotic Apoptosis	Infection Cancer
Streptozotocin (Streptozocin; STZ) is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells .

HY-100017

BAY-876 50+ Cited Publications	GLUT Disulfidptosis	Cancer
BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC₅₀ of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .

HY-B0239

Chloramphenicol 15+ Cited Publications	Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy Apoptosis Beclin1 JNK Akt MMP	Infection Cancer
Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .

HY-123986

CTPI-2 10+ Cited Publications	Mitochondrial Metabolism	Inflammation/Immunology Cancer
CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a K_D of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity .

HY-145597

KL-11743 5 Publications Verification	GLUT Disulfidptosis	Metabolic Disease Cancer
KL-11743 is a potent, orally active, and glucose-competitive inhibitor of the class I glucose transporters, with IC₅₀s of 115, 137, 90, and 68 nM for GLUT1, GLUT2, GLUT3, and GLUT4, respectively. KL-11743 specifically blocks glucose metabolism. KL-11743 can synergize with electron transport inhibitors to induce cell death. In addition, KL-11743 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis .

HY-N0755

Rhoifolin	Insulin Receptor GLUT NF-κB p38 MAPK Autophagy	Metabolic Disease Endocrinology Cancer
Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

HY-128574

D927 DS11252927	GLUT PI3K Akt	Metabolic Disease
D927 (DS11252927) is an orally active glucose transporter type 4 (GLUT4) translocation activator with an EC₅₀ of 0.14 μM. D927 enhances the binding affinity of PI3Kα catalytic subunit p110α to canonical RAS proteins (KRAS4A, KRAS4B) and RRAS, RRAS2, MRAS. D927 activates the PI3Kα-AKT pathway (increasing phosphorylation of AKT, p70S6 kinase) without affecting the RAF-ERK1/2 pathway. D927 improves hyperglycemia in type 1 and type 2 diabetes mice model. D927 can be used for the study of glucose homeostasis disorders and diabetes .

HY-19331

WZB117 20+ Cited Publications	GLUT	Cancer
WZB117 is a glucose transporter 1 (Glut1) inhibitor, which downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.

HY-N0668

Rubusoside 2 Publications Verification	GLUT Amylases NF-κB	Metabolic Disease Inflammation/Immunology Cancer
Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase) .

HY-18728

STF-31 15+ Cited Publications	GLUT Autophagy	Cancer
STF-31 is a selective inhibitor of glucose transporter 1 (GLUT1), with an IC₅₀ of 1 μM. STF-31 is also a NAMPT inhibitor. STF-31 inhibits glucose uptake in renal cell carcinoma (RCC) 4 cells .

HY-123011

Henagliflozin SHR3824	SGLT	Metabolic Disease
Henagliflozin (SHR3824) is a potent selective sodium-glucose co-transporter 2 (SGLT2) inhibitor with the IC₅₀ values of 2.38 and 4324 nM for human SGLT2 and SGLT1, respectively. Henagliflozin can be used in diabetes research .

HY-A0080

Aminohippurate sodium 4 Publications Verification Sodium p-aminohippurate; p-Aminohippuric acid sodium salt	Biochemical Assay Reagents
Aminohippurate sodium is a renal tubular transport inhibitor and a substrate for organic anion transporters. Aminohippurate sodium inhibits renal tubular reabsorption of phosphate and promotes increased urinary phosphate excretion. Aminohippurate sodium inhibits renal tubular reabsorption of vitamin C as well as the transport of glucose .

HY-108052

Delphinidin 3-glucoside chloride 1 Publications Verification Delphinidin 3-O-glucoside chloride; Delphinidin 3-O-β-glucoside chloride	EGFR Apoptosis Akt	Cardiovascular Disease Cancer
Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL) . Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC₅₀ of 9.7 μM . Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC₅₀ of 2.37 µM . Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction .

HY-N0468

Rebaudioside D 1 Publications Verification	FXR Acetyl-CoA Carboxylase	Metabolic Disease
Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .

HY-139605

GLUT inhibitor-1 1 Publications Verification	GLUT	Inflammation/Immunology Cancer
GLUT inhibitor-1 is a potent and orally active inhibitor of glucose transporters, targeting both GLUT1 and GLUT3, with IC₅₀s of 242 nM and 179 nM, respectively. GLUT inhibitor-1 has the potential for the reaesrch of cancers and autoimmune diseases .

HY-N4137

Tormentic acid 2 Publications Verification	Others	Cardiovascular Disease Inflammation/Immunology
Tormentic acid, a triterpene isolated from Rosa rugosa, exerts anti-inflammatory, antihyperlipidemic, and anti-atherogenic properties .

HY-124113

4'-Bromo-resveratrol 4′‐BR	Sirtuin Apoptosis Caspase Lactate Dehydrogenase GLUT	Metabolic Disease Inflammation/Immunology Cancer
4'-Bromo-resveratrol (4′‐BR) is a dual SIRT1/SIRT3 inhibitor with an IC₅₀ of 0.2 mM for both targets. 4'-Bromo-resveratrol induces caspase-dependent apoptosis, induces G0/G1 cell cycle arrest, and inhiibits proliferation. 4'-Bromo-resveratrol reduces lactate production, glucose uptake, and NAD ⁺/NADH ratio, and downregulates lactate dehydrogenase A and glucose transporter 1 (GLUT1). 4'-Bromo-resveratrol can be used for the research of melanoma .

HY-101849

Fasentin 4 Publications Verification	GLUT TNF Receptor Apoptosis	Cardiovascular Disease Cancer
Fasentin, a potent glucose uptake inhibitor, inhibits GLUT-1/GLUT-4 transporters. Fasentin preferentially inhibits GLUT4 (IC₅₀=68 μM) over GLUT1. Fasentin is a death receptor stimuli (FAS) sensitizer and sensitizes cells to FAS-induced cell death. Fasentin is also a tumor necrosis factor (TNF) apoptosis-inducing ligand sensitizer. Fasentin blocks glucose uptake in cancer cell lines and has anti-angiogenic activity .

HY-175674

NGI-235	NF-κB Toll-like Receptor (TLR) GLUT	Inflammation/Immunology
NGI-235 is an STT3A-selective oligosaccharyltransferase complex OST-A inhibitor. NGI-235 preferentially inhibits OST-A catalytic activity, impairing N-glycosylation of OST-A substrates. NGI-235 causes the hypoglycosylation of both TLR4, GLUT1 and inhibits NF-κB signaling. NGI-235 can be used for the research of inflammation .

HY-107207

Kaempferol 3-neohesperidoside 3 Publications Verification Kaempferol 3-O-neohesperidoside	Insulin Receptor PI3K PKC	Metabolic Disease
Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside) is a flavonoid. Kaempferol 3-neohesperidoside mimics insulin action via the PI3K/PKC pathway, significantly promoting glucose uptake and increasing muscle glycogen content in rat soleus muscles. Kaempferol 3-neohesperidoside also exhibits anti-glycation activity. Kaempferol 3-neohesperidoside binds to albumin through hydrogen bonding and hydrophobic interactions, and inhibits the formation of advanced glycation end products. Kaempferol 3-neohesperidoside can be used in studies of diabetes and its related complications .

HY-120103

PF-06649298 1 Publications Verification	Sodium Channel	Metabolic Disease
PF-06649298 is a *sodium-coupled citrate transporter* (NaCT or SLC13A5) inhibitor. PF-06649298 specifically interacts with NaCT with an IC₅₀** value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used for the research of regulating glucose metabolism and lipid metabolism .

HY-N9435

28-Homobrassinolide 3 Publications Verification	Others	Metabolic Disease
28-Homobrassinolide is a phytosteroid. 28-Homobrassinolide can be used for the research of cholesterol and glucose homeostasis .

HY-N7433

4,6-O-Ethylidene-α-D-glucose Ethylidene-glucose	GLUT Endogenous Metabolite	Metabolic Disease
4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a K_i of 12 mM for wild-type 2-deoxy-D-glucose transport .

HY-128723

Dapagliflozin impurity	SGLT	Others
Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor .

HY-N6935

Sennidin B	DNA/RNA Synthesis HCV Akt GLUT	Infection Metabolic Disease
Sennidin B, a stereoisomer isolated from the leaves of Cassia angustifolia, has lower activity than Sennidin A. Sennidin A inhibits HCV NS3 helicase, with an IC₅₀ of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation .

HY-136830

ADP-Glucose disodium Adenosine-5'-diphosphoglucose disodium	Biochemical Assay Reagents	Others
ADP-Glucose disodiumIs an immediate precursor for the biosynthesis of storage polysaccharides in plants, green algae and cyanobacteria, and structural polysaccharides in some bacteria, by the addition of glucose. It is used to produce amylose, amylopectin, starch and other polysaccharides by amylose synthase or starch synthase in plastids. ADPGUsually produced in plastids, although it can be biosynthesized in the cytoplasm of some grasses and imported into plastids by membrane-bound transporters .

HY-B0239R

Chloramphenicol (Standard)	Reference Standards Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase VEGFR Autophagy Apoptosis Beclin1 JNK Akt MMP	Infection Cancer
Chloramphenicol (Standard) is the analytical standard of Chloramphenicol. This product is intended for research and analytical applications. Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .

HY-151486

GLUT1-IN-1	GLUT	Cancer
GLUT1-IN-1 is a glucose transporter 1 (GLUT1) inhibitor and has a GLUT1-specific inactivation ability. GLUT1-IN-1 exhibits concentration-dependent cytotoxicity for HeLa, A549 and HepG2 cells with IC₅₀ values of 5.49 μM, 11.14 μM, and 8.73 μM, respectively. GLUT1-IN-1 can be used for the research of photodynamic therapy (PDT) and severals cancer .

HY-161501

3-Fluoro-evodiamine glucose	GLUT Topoisomerase Apoptosis	Cancer
3-Fluoro-evodiamine glucose (Compound 8) is an evodiamine-glucose conjugate. 3-Fluoro-evodiamine glucose activates the expression of glucose transporter 1 (GLUT1), and inhibits topoisomerase I/II. 3-Fluoro-evodiamine glucose induces apoptosis and arrests the cell cycle at G2/M phase. 3-Fluoro-evodiamine glucose exhibits antitumor efficacy in vivo and in vitro, without significant toxicity .

HY-B1080A

Tilorone 2 Publications Verification	Influenza Virus Akt	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Tilorone is an orally active antiviral agent and interferon inducer that also has potential antineoplastic, immunomodulatory, and metabolic modulating effects. Tilorone induces an abnormally delayed interferon response and primarily stimulates interferon production in lymphoid tissue. Thus, Tilorone exerts antiviral effects and can be used as a chemotherapeutic agent. Tilorone has the potential to inhibit type 2 diabetes by increasing glucose uptake in vivo and in skeletal muscle cells by enhancing Akt2/AS160 signaling and glucose transporter levels .

HY-10449A

Luseogliflozin hydrate TS 071 hydrate	SGLT	Metabolic Disease
Luseogliflozin (TS 071) hydrate is a selective potent and orally active second-generation sodium-glucose co-transporter 2 (SGLT2) inhibitor with an IC₅₀ of 2.26 nM. Luseogliflozin hydrate can be used for the research of type 2 diabetes mellitus (T2DM) .

HY-153113

Rongliflozin DJT1116PG	SGLT	Endocrinology
Rongliflozin (DJT1116PG) is a selective and orally active inhibitor of sodium-glucose co-transporter-2 (SGLT-2). Rongliflozin can be used for the research of type 2 diabetes mellitus (T2DM) .

HY-139047

SW157765	GLUT	Cancer
SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs .

HY-16605

SIRT6-IN-6	Sirtuin GLUT	Metabolic Disease
SIRT6-IN-6 (compound 6d) is a potent and selective SIRT6 inhibitor with an IC₅₀ of 4.93 μM and a K_i of ~10 μM. SIRT6-IN-6 shows selectivity against other members of the HDAC family (SIRT1-3 and HDAC1-11). SIRT6-IN-6 significantly increases the level of glucose transporter GLUT-1, thereby reducing blood glucose in a mouse model of type 2 diabetes. SIRT6-IN-6 can be used for type 2 diabetes research .

HY-153612

MMV009085	GLUT Parasite	Infection Inflammation/Immunology
MMV009085 is a potent PfHT1 (Plasmodium falciparum hexose transporter)-specific inhibitor and a potential anti-malarial agent . MMV009085 is also a human glucose transporter inhibitor, it has high potency in inhibiting both glucose uptake (IC₅₀: 2.6 μM in glucose uptake assay) and growth of the parasites (EC₅₀: 1.23±0.04 μM against 3D7) .

HY-176050

Rapaglutin A RgA; JW11-D2	GLUT	Cancer
Rapaglutin A is a glucose transporter (GLUT) inhibitor. Rapaglutin A is a pan-GLUT inhibitor of Class I isoforms GLUT1, GLUT3, and GLUT4 with an IC₅₀ of 12 nM. Rapaglutin A has an inhibitory effect on A549 proliferation .

HY-N6936

Sennidin A	DNA/RNA Synthesis HCV Akt GLUT	Infection
Sennidin A, isolated from the leaves of Cassia angustifolia, inhibits HCV NS3 helicase, with an IC₅₀ of 0.8 μM. Sennidin A induces phosphorylation of Akt and glucose transporter 4 (GLUT4) translocation. Sennidin A stimulates the glucose incorporation .

HY-174145

GLUT4 activator 3	GLUT	Metabolic Disease
GLUT4 activator 3 (Compound 13a) is an antidiabetic agent targeting GLUT4 translocation in skeletal muscle. GLUT4 activator 3 can promote the translocation of glucose transporter 4 (GLUT4) in skeletal muscle cells. GLUT4 activator 3 reduces blood glucose in STZ-induced diabetic rats .

HY-158056

URAT1/GLUT9-IN-1	GLUT URAT1	Metabolic Disease
URAT1/GLUT9-IN-1 (compound 29) can inhibit both uric acid transporter 1 (URAT1) (IC₅₀=2.01 μM) and glucose transporter 9 (GLUT9) (IC₅₀=18.21 μM). URAT1/GLUT9-IN-1 exhibits favorable pharmacokinetic properties and oral bioavailability. URAT1/GLUT9-IN-1 can be uesd for gout and hyperuricemia research .

HY-108052R

Delphinidin 3-glucoside chloride (Standard) Delphinidin 3-O-glucoside chloride (Standard); Delphinidin 3-O-β-glucoside chloride (Standard)	Reference Standards EGFR Apoptosis Akt	Cardiovascular Disease Cancer
Delphinidin 3-glucoside (chloride) (Standard) is the analytical standard of Delphinidin 3-glucoside (chloride). This product is intended for research and analytical applications. Delphinidin 3-glucoside chloride (Delphinidin 3-O-glucoside chloride) is an active anthocyanin found in Hibiscus sabdariffa extract. Delphinidin 3-glucoside chloride induces a pro-apoptotic effect in B cell chronic lymphocytic leukaemia (B CLL) . Delphinidin 3-glucoside chloride exerts phytoestrogen activity by binding to ERβ, with an IC50 of 9.7 μM . Delphinidin-3-O-glucoside chloride inhibits EGFR with an IC50 of 2.37 µM . Delphinidin 3-glucoside chloride exhibits antitumor effects through pAKT/IRF1/HOTAIR pathway. Delphinidin 3-glucoside chloride exhibits efficacy against oxidative stress, inhibits platelet activation and endothelial dysfunction .

HY-B0239S2

Threo-Chloramphenicol-d6	JNK Apoptosis VEGFR MMP Bacterial Akt Autophagy HIF/HIF Prolyl-Hydroxylase Antibiotic Beclin1	Cancer
Threo-Chloramphenicol-d₆ is the deuterium labeled Chloramphenicol . Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .

HY-115606

ML077	NKCC Endogenous Metabolite	Neurological Disease
ML007 is a selective antagonist targeting the neuron-specific potassium-chloride co-transporter 2 (KCC2) with an IC₅₀ for KCC2 is 537 nM, while its inhibitory activity on KCC1 is extremely weak (IC₅₀ > 50 μM). ML077 inhibits the chloride ion excretion function of KCC2, increasing the intracellular chloride ion concentration, thereby enhancing the depolarization mediated by chloride ion channels. ML007 can promote glucose-stimulated insulin secretion (GSIS) without relying on KATP channels. ML007 can be used to study the functions related to pain, epilepsy, and insulin secretion .

HY-N0755R

Rhoifolin (Standard)	Reference Standards Insulin Receptor GLUT NF-κB p38 MAPK Autophagy	Metabolic Disease Endocrinology Cancer
Rhoifolin (Standard) is the analytical standard of Rhoifolin. This product is intended for research and analytical applications. Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

HY-N0668R

Rubusoside (Standard)	GLUT Amylases NF-κB Reference Standards	Metabolic Disease Inflammation/Immunology Cancer
Rubusoside (Standard) is the analytical standard of Rubusoside. This product is intended for research and analytical applications. Rubusoside is a diterpene glycoside that is also a sweetener and solubilizer with anti-angiogenic, anti-cancer, anti-obesity, anti-allergic and anti-asthmatic effects. Rubusoside attenuates airway hyperresponsiveness and reduces inflammatory cells in bronchoalveolar lavage fluid (BALF), reducing OVA (HY-W250978)-induced airway inflammation. Rubusoside also prevents palmitic acid-induced lipotoxicity in pancreatic INS-1 cells, reduces the transport of human glucose transporters GLUT-1 and fructose GLUT-5, and inhibits NF-κB and α-amylase (α-amylase) .

HY-N0468R

Rebaudioside D (Standard)	Reference Standards Acetyl-CoA Carboxylase FXR	Metabolic Disease
Rebaudioside D (Standard) is the analytical standard of Rebaudioside D. This product is intended for research and analytical applications. Rebaudioside D is an orally active sweetener that targets and activates FXR, modulates Acetyl-CoA Carboxylase, and inhibits 3-hydroxy-3-methylglutaryl-CoA reductase. Rebaudioside D regulates bile acid homeostasis and lipid metabolism, reduces the synthesis rates of fatty acids and cholesterol, and exerts multiple effects including anti-adipogenesis, hepatoprotection, anti-steatosis, gut microbiota modulation, enhancement of secondary bile acid metabolism, anti-endotoxin activity, regulation of bile acid transport, and inhibition of bile acid efflux. Rebaudioside D also reduces body weight gain, visceral fat accumulation, hepatic triglyceride and cholesterol accumulation, hepatic lipid peroxidation, and decreases the circulating level of lipopolysaccharide-binding protein. Rebaudioside D additionally enhances the secondary bile acid metabolic pathway of intestinal bacteria, upregulates the gene expression of ileal organic solute transporter α, and downregulates the gene expression of hepatic bile salt export pump. Rebaudioside D does not affect glucose homeostasis, alter total caloric intake or fecal energy excretion, induce weight gain, exacerbate obesity, promote hepatic steatosis, impair brown adipose tissue function, nor change skeletal muscle metabolism-related proteins. Rebaudioside D can be used in diet-induced obesity and obesity-related research .

HY-N7433R

4,6-O-Ethylidene-α-D-glucose (Standard) Ethylidene-glucose (Standard)	Reference Standards GLUT Endogenous Metabolite	Metabolic Disease
4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport .

HY-147115

4-Azidophlorizin	Fluorescent Dye	Others
4-Azidophlorizin is a high affinity probe and photoaffinity label for the **glucose transporter** in brush border membranes . 4-Azidophlorizin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-176051

Rapaglutin E RgE	GLUT	Cancer
Rapaglutin E (RgE) is a glucose transporter (GLUT) inhibitor. Rapaglutin E exhibits dose-dependent inhibition of [ ³H]-2DG uptake in A549, Jurkat T, PANC10.05, and RBC, with IC₅₀ values 8.9 nM, 3.1 nM, 35.5 nM, 74.2 nM. Rapaglutin E inhibits cell proliferation in A549, PANC10.05, HeLa, Jurkat T, and HEK293T cells .

HY-168989

Olorigliflozin	SGLT	Metabolic Disease
Olorigliflozin is a sodium glucose co-transporter inhibitor with anti-hyperglycemic effects .

HY-155093

GLUT1-IN-3	GLUT	Neurological Disease
GLUT1-IN-3 (Compd 4b), an investigational compound associated with type 1 glucose transporter deficiency syndrome, potently suppresses seizures .

Cat. No.	Product Name

HY-L083

Anti-Cancer Metabolism Compound Library

3,552 compounds

Mutations in oncogenes and tumor suppressor genes can modify multiple signaling pathways and in turn cell metabolism, which facilitates tumorigenesis. The paramount hallmark of tumor metabolism is “aerobic glycolysis” or the Warburg effect, coined by Otto Warburg in 1926, in which cancer cells produce most of energy from glycolysis pathway regardless of whether in aerobic or anaerobic condition. Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside. The increased uptake of glucose is facilitated by the overexpression of several isoforms of membrane glucose transporters (GLUTs). Likewise, the metabolic pathways of glutamine, amino acid and fat metabolism are also altered. Recent trends in anti-cancer drug discovery suggests that targeting the altered metabolic pathways of cancer cells result in energy crisis inside the cancer cells and can selectively inhibit cancer cell proliferation by delaying or suppressing tumor growth.

MCE provides a unique collection of 3,552 compounds which cover various tumor metabolism-related signaling pathways. These compounds can be used for anti-cancer metabolism targets identification, validation as well anti-cancer drug discovery.

HY-L064

Glutamine Metabolism Compound Library

1,690 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 1,690 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Cat. No.	Product Name	Type

HY-D3199

NIR‐fluorescent glucose	Fluorescent Dyes
NIR-fluorescent glucose is a functional glucose-based fluorescent imaging agent. Conjugated with the nitrobenzoselenadiazole-based SCOTfluor (compound 9), NIR-fluorescent glucose acts as a substrate for GLUT4 and GLUT2 transporters. NIR-fluorescent glucose enables the visualization of glucose uptake in live cells and in vivo .

Cat. No.	Product Name	Type

HY-136830

ADP-Glucose disodium

Adenosine-5'-diphosphoglucose disodium

Biochemical Assay Reagents

ADP-Glucose disodiumIs an immediate precursor for the biosynthesis of storage polysaccharides in plants, green algae and cyanobacteria, and structural polysaccharides in some bacteria, by the addition of glucose. It is used to produce amylose, amylopectin, starch and other polysaccharides by amylose synthase or starch synthase in plastids. ADPGUsually produced in plastids, although it can be biosynthesized in the cytoplasm of some grasses and imported into plastids by membrane-bound transporters .

Species:	Human (2)
Tag:	His (2) MBP (1) Flag (1)
Source:	E. coli Cell-free (1) Sf9 insect cells (1)

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HY-P702441

	SLC2A9 Protein, Human (Cell-Free, His) Solute carrier family 2, facilitated glucose transporter member 9; glucose transporter type 9; GLUT-9; Urate transporter	Human	E. coli Cell-free
	SLC2A9 Protein, validated by studies, serves as a high-capacity urate transporter in proximal tubules. Additionally, it exhibits residual glucose and fructose transporter activities. Its rapid urate transport (45- to 60-fold faster than glucose) underscores its pivotal role. Notably, it excludes galactose transport and modestly facilitates adenine uptake, contributing to diverse physiological processes. SLC2A9 Protein, Human (Cell-Free, His) is the recombinant human-derived SLC2A9 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SLC2A9 Protein, Human (Cell-Free, His) is 540 a.a., with molecular weight of 60.2 kDa.

HY-P702035

	SLC37A4 Protein, Human (sf9, His, MBP, FLAG) SLC37A4; glucose-6-phosphate exchanger SLC37A4; glucose-5-phosphate transporter; glucose-6-phosphate translocase; Solute carrier family 37 member 4; Transformation-related gene 19 protein; TRG-19	Human	Sf9 insect cells
	SLC37A4 protein, an endoplasmic reticulum antiporter, transports glucose-6-phosphate into the endoplasmic reticulum lumen while moving inorganic phosphate in the opposite direction. This function is integral to glucose production through glycogenolysis and gluconeogenesis, underscoring SLC37A4's central role in regulating blood glucose levels and maintaining metabolic balance. SLC37A4 Protein, Human (sf9, His, MBP, FLAG) is the recombinant human-derived SLC37A4 protein, expressed by sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0239S2

Threo-Chloramphenicol-d6

Threo-Chloramphenicol-d₆ is the deuterium labeled Chloramphenicol . Chloramphenicol is an orally active, potent and broad-spectrum antibiotic. Chloramphenicol shows antibacterial activity. Chloramphenicol represses the oxygen-labile transcription factor and hypoxia inducible factor-1 alpha (HIF-1α) in hypoxic A549 and H1299 cells. Chloramphenicol suppresses the mRNA levels of vascular endothelial growth factor (VEGF) and glucose transporter 1, eventually decreasing VEGF release. Chloramphenicol can be used for anaerobic infections and lung cancer research .

Host:	Mouse (5) Rabbit (8)
Reactivity:	Human (11) mouse (1) rat (1) Rat (6) Mouse (10) human (1)
Application:	IHC-P (6) ICC/IF (6) IF-Tissue (1) IP (1) IHC-F (1) WB (13) FC (4) ELISA (5)
Isotype:	IgG (9) IgG1 (2) IgG2b (2)
Conjugation:	Non-conjugated (13)
Clonality:	Polyclonal (1) Monoclonal (7) Monoclonal Antibody (1) Recombinant (5)
Modification:	Unmodified (10)

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HY-P82924

	Glucose Transporter GLUT2 Antibody (YA2669) liver; glucose transporter 2; glucose transporter GLUT2; glucose transporter type 2; glucose transporter; liver/islet; GLUT2; GTT2; SLC2A2	WB	Human
	Glucose Transporter GLUT2 Antibody (YA2669) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucose Transporter GLUT2.

HY-P80406

	Glucose Transporter GLUT2 Antibody (YA408) 1 Publications Verification	WB, IHC-P, FC	Human
	Glucose Transporter GLUT2 Antibody (YA408) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucose Transporter GLUT2.

HY-P80495

	Glucose Transporter GLUT4 Antibody (YA753) 1 Publications Verification	WB, ICC/IF, IHC-P	Human, Mouse
	Glucose Transporter GLUT4 Antibody (YA753) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Glucose Transporter GLUT4.

HY-P80494

	Glucose Transporter GLUT1 Antibody (YA410)	WB, ICC/IF, IHC-P, FC	Human, Mouse
	Glucose Transporter GLUT1 Antibody (YA410) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucose Transporter GLUT1.

HY-P85845

	Glucose Transporter GLUT1 Antibody (YA5537)	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Glucose Transporter GLUT1 Antibody (YA5537) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Glucose Transporter GLUT1.

HY-P89658

	Glucose Transporter Glut10 Antibody (YA9002)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	Glucose Transporter Glut10 Antibody (YA9002) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Glucose Transporter Glut10.

HY-P80689

	Glucose Transporter GLUT4 Antibody SLC2A4; GLUT4; Solute carrier family 2; facilitated glucose transporter member 4; glucose transporter type 4; insulin-responsive; GLUT-4	WB, IHC-P, ELISA	Human, Mouse, Rat
	Glucose Transporter GLUT4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Glucose Transporter GLUT4.

HY-P83177

	Glucose Transporter GLUT3 Antibody (YA2922) SLC2A3; GLUT3; Solute carrier family 2; facilitated glucose transporter member 3; glucose transporter type 3; brain; GLUT-3	WB	Human, Mouse, Rat
	Glucose Transporter GLUT3 Antibody (YA2922) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucose Transporter GLUT3.

HY-P83177A

	Glucose Transporter GLUT3 Antibody (YA2922)(PBS only) SLC2A3; GLUT3; Solute carrier family 2; facilitated glucose transporter member 3; glucose transporter type 3; brain; GLUT-3	WB	Human, Mouse, Rat
	Glucose Transporter GLUT3 Antibody (YA2922) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucose Transporter GLUT3.

HY-P84098

	Glucose Transporter GLUT4 Antibody (YA3795) GLUT4	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
	Glucose Transporter GLUT4 Antibody (YA3795) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Glucose Transporter GLUT4.

HY-P86894

	Glucose Transporter GLUT4 Antibody (YA6587) insulin-responsive antibody; glucose transporter GLUT 4 antibody; glucose transporter type 4 antibody; glucose transporter type 4 insulin responsive antibody; GLUT 4 antibody; GLUT-4 antibody; GLUT4 antibody; GTR4_HUMAN antibody; Insulin responsive glucose transporter type 4 antibody; kug antibody; insulin-responsive antibody; glucose transporter GLUT 4 antibody; glucose transporter type 4 antibody; glucose transporter type 4 insulin responsive antibody; GLUT 4 antibody; GLUT-4 antibody; GLUT4 antibody; GTR4_HUMAN antibody; Insulin responsive glucose transporter type 4 antibody; kug antibody; SLC 2A4 antibody; SLC2A4 antibody; solute carrier family 2 (facilitated glucose transporter) member 4 antibody; Solute carrier family 2 member 4 antibody; Solute carrier family 2, facilitated glucose transporter member 4 antibody;	WB, IHC-F	Mouse, Rat
	Glucose Transporter GLUT4 Antibody (YA6587) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucose Transporter GLUT4.

HY-P810626

	*Phospho-Glucose* Transporter GLUT4 (Ser488) Antibody (YA9888)** SLC2A4; GLUT4; Solute carrier family 2; facilitated glucose transporter member 4; glucose transporter type 4; insulin-responsive; GLUT-4	WB	Human, Mouse, Rat
	Phospho-Glucose Transporter GLUT4 (Ser488) Antibody (YA9888) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-Glucose Transporter GLUT4 (Ser488).

HY-P84098A

	Glucose Transporter GLUT4 Antibody (YA3795)(PBS only) GLUT4	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse
	Glucose Transporter GLUT4 Antibody (YA3795) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Glucose Transporter GLUT4.

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Free Sample	Yes No
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Cat. No.	Product Name		Classification

HY-147115

4-Azidophlorizin		Azide
4-Azidophlorizin is a high affinity probe and photoaffinity label for the **glucose transporter** in brush border membranes . 4-Azidophlorizin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-174547

Human PDX1 mRNA		mRNA Transcription Factors
Human PDX1 mRNA encodes the human pancreatic and duodenal homeobox 1 (PDX1) protein, a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. PDX1 may be involved in the early development of the pancreas. It also plays a major role in glucose-dependent regulation of insulin gene expression.

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glucose transporter

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

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