5 Results for "

heat generation

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "heat generation" in MCE Product Catalog:

  • Categories Recommended:
    More
N-Acetyl-L-tyrosine
N-Acetyl-L-tyrosine
0 Images
Cat. No.: HY-W012382
CAS No.: 537-55-3
Category:  

Human Gut Microbiota Metabolites Monophenols Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endocrine diseases Phenols Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .
loading...
    loading...
View All Sizes
N-Acetyl-L-tyrosine-d3
N-Acetyl-L-tyrosine-d3
0 Images
Cat. No.: HY-W012382S
N-Acetyl-L-tyrosine-d3 is the deuterated form of N-Acetyl-L-tyrosine (HY-W012382). N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .
loading...
    loading...
View All Sizes
Cemdomespib
Cemdomespib
0 Images
Cat. No.: HY-145559
CAS No.: 1450642-92-8
Synonyms: KU-596
Target:  

HSP

Research Areas:  

Metabolic Disease

Cemdomespib (KU-596) is a highly bioavailable second-generation Hsp90 modulator. Cemdomespib has shown efficacy in improving sensory deficits in models of diabetic peripheral neuropathy. Cemdomespib induces Hsp70 levels and manifest neuroprotective activity through induction of the heat shock response .
loading...
    loading...
View All Sizes
N-Acetyl-L-tyrosine (Standard)
N-Acetyl-L-tyrosine (Standard)
0 Images
Cat. No.: HY-W012382R
CAS No.: 537-55-3
Category:  

Human Gut Microbiota Metabolites Microorganisms Monophenols Ketones, Aldehydes, Acids Disease markers Endocrine diseases Phenols Endogenous metabolite

Target:  

Reference Standards Endogenous Metabolite

N-Acetyl-L-tyrosine (Standard) is the analytical standard of N-Acetyl-L-tyrosine (HY-W012382). This product is intended for research and analytical applications. N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .
loading...
    loading...
View All Sizes
VWK147
VWK147
0 Images
Cat. No.: HY-181062
Target:  

HSP Apoptosis Autophagy ULK RIP kinase CDK

Research Areas:  

Cancer

VWK147 is a second-generation HSP90 C-terminal domain (CTD) inhibitor. VWK147 targets the CTD dimerization interface, prevents HSP90 CTD dimerization, disrupts co-chaperone PPID binding to HSP90 CTD, and inhibits HSP90 chaperone function dependent on dimerization. VWK147 reduces protein levels of HSP90 client proteins ULK1, RIPK1, and CDK4 without inducing a heat shock response. VWK147 induces cell death, including apoptosis, in Cisplatin (HY-17394)-sensitive and -resistant urothelial carcinoma cells. VWK147 induces LC3-II accumulation, inhibits autophagosome-lysosome fusion to block canonical autophagy, and induces non-canonical LC3 lipidation independent of ULK1 and PIK3C3 complexes. VWK147 can be used for the research of urothelial carcinoma .
loading...
    loading...
View All Sizes
Assay Types