3 Results for "

hepatic lipid biomarker

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "hepatic lipid biomarker" in MCE Product Catalog:

6
6 Cited Publications
Cat. No.: HY-N9933
CAS No.: 25696-60-0
Synonyms: TβMCA
Tauro-β-muricholic acid (TβMCA) is an orally active trihydroxylated bile acid and a competitive, reversible FXR antagonist (IC50=40 μM). Tauro-β-muricholic acid inhibits bile acid-induced hepatocyte apoptosis by maintaining mitochondrial membrane potential, while simultaneously inhibiting intestinal FXR signaling, affecting bile acid synthesis, hepatic lipid metabolism, and insulin sensitivity. Accumulation of tauro-β-muricholic acid disrupts metabolic homeostasis, promoting cancer stem cell proliferation and tumor progression. The mechanisms of tauro-β-muricholic acid involve two aspects: first, inhibiting the translocation of the pro-apoptotic protein Bax to mitochondria and maintaining mitochondrial membrane potential (MMP); and second, blocking the FXR signaling pathway to regulate bile acid metabolism, reduce serum ceramide production, and downregulate the hepatic SREBP1C/CIDEA pathway. Tauro-β-muricholic acid possesses anti-hepatocyte apoptosis, bile acid homeostasis regulation, and liver fat accumulation reduction properties, and also functions as a biomarker, making it useful in the study of diseases such as bile acid metabolism disorders, non-alcoholic fatty liver disease, colorectal cancer, and liver fibrosis .
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Cat. No.: HY-156041
CAS No.: 97281-40-8
Purity:  ≥99.0%
Synonyms: Lyso-PE (egg); LPE (egg); L-α-lysophosphatidylethanolamine
Lysophosphatidylethanolamines, egg (Lyso-PE (egg); LPE (egg); L-α-lysophosphatidylethanolamine) is a naturally occurring lysophospholipid isolated from purified egg phosphatidylcholine. Lysophosphatidylethanolamines, egg acts as a hepatic lipid biomarker in oleic acid-induced hepatocytes. The level of Lysophosphatidylethanolamines, egg decreases in mice fed a high-fat diet. Lysophosphatidylethanolamines, egg can be used in studies related to non-alcoholic fatty liver disease and hyperlipidemia .
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Cat. No.: HY-129297
CAS No.: 86879-39-2
Purity:  99.57%
CMPF can be found in trace constituent of urine and blood. CMPF is a biomarker of type 2 diabetes. CMPF can act on the β cell and induces impaired mitochondrial function. CMPF decreases glucose-induced ATP accumulation, and induces oxidative stress. CMPF reverses hepatic lipid accumulation and improves insulin sensitivity in obese mice .
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