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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
hepatocarcinogenesis
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "hepatocarcinogenesis" in MCE Product Catalog:
Target:
Target:
Cat. No.: HY-W017200
CAS No.: 13073-35-3
Synonyms: L-ETH
Target:
Research Areas:
L-Ethionine (L-ETH) is an amino acid derivative. L-Ethionine serves as a substrate for ATP:L-methionine S-adenosyltransferase, which targets its L-stereoisomer. L-Ethionine blocks the synthesis of N 6-dimethyladenosine in rat liver tRNA/4S RNA via its major hepatic metabolite S-adenosylethionine, inducing methyl-deficient rat liver tRNA/4S RNA. L-Ethionine can be used in studies of liver cancer and hepatocarcinogenesis mechanisms .
Cat. No.: HY-164082
CAS No.: 21340-68-1
Synonyms: Clofenapate methyl ester; MCP
Target:
Research Areas:
Methyl clofenapate (Clofenapate methyl ester; MCP) is a peroxisome proliferator, which can induce hypolipidemia, peroxisome proliferation, and hepatocarcinogenesis .
Cat. No.: HY-113261S
CAS No.: 2847775-85-1
Cat. No.: HY-113261R
CAS No.: 38677-66-6
Cat. No.: HY-113261S1
Cat. No.: HY-L101
3,003 compounds
Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.
Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc.
MCE offers a unique collection of 3,003 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
