121 Results for "

hepatocyte growth factor

" in MedChemExpress (MCE) Product Catalog:
Products (121)

121 Results for "hepatocyte growth factor" in MCE Product Catalog:

6
6 Cited Publications
Cat. No.: HY-16969
CAS No.: 1401708-83-5
Synonyms: PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2
Target:  

c-Met/HGFR

Research Areas:  

Neurological Disease

Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease .
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6
6 Cited Publications
Cat. No.: HY-P7121
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HGF; hepatocyte growth factor (Hepapoietin A; Scatter factor); Prev. DFNB39; Lung Fibroblast-Derived Mitogen; HPTA; Hepatopoietin-A; SF; Scatter factor; F-TCF; Deafness, Autosomal Recessive 39; HGFB; Hepatopoietin A; hepatocyte growth factor; Fibroblast-D
Species:  
Human
Source:  
CHO
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2
2 Cited Publications
Cat. No.: HY-114363A
CAS No.: 1832686-44-8
Purity:  98.53%
Target:  

c-Met/HGFR

Research Areas:  

Cancer

SRI 31215 (TFA) is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer .
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2
2 Cited Publications
Cat. No.: HY-P70627
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HGF; hepatocyte growth factor (Hepapoietin A; Scatter factor); Prev. DFNB39; Lung Fibroblast-Derived Mitogen; HPTA; Hepatopoietin-A; SF; Scatter factor; F-TCF; Deafness, Autosomal Recessive 39; HGFB; Hepatopoietin A; hepatocyte growth factor; Fibroblast-Derived Tumor Cytotoxic factor
Species:  
Human
Source:  
HEK293
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2
2 Cited Publications
Cat. No.: HY-P70832
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HABP2; factor VII Activating Protein; Hyaluronan Binding Protein 2; Hyaluronan-Binding Protein 2; HGFAL; FVII Activator; PHBP; PHBSP; FSAP; Hyaluronic Acid Binding Protein 2; HABP; Plasma Hyaluronan-Binding Protein; hepatocyte growth factor Activator-Like
Species:  
Human
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P1415A
Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .
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1
1 Cited Publications
Cat. No.: HY-P701103
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MST1; NF15S2; Prev. D3F15S2; Macrophage Stimulatory Protein; Prev. DNF15S2; Macrophage Stimulating 1 (hepatocyte growth factor-Like); Prev. HGFL; hepatocyte growth factor-Like Protein Homolog; MSP; hepatocyte growth factor-Like; hepatocyte growth factor-L
Species:  
Mouse
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P73101
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HGF; hepatocyte growth factor (Hepapoietin A; Scatter factor); Prev. DFNB39; Lung Fibroblast-Derived Mitogen; HPTA; Hepatopoietin-A; SF; Scatter factor; F-TCF; Deafness, Autosomal Recessive 39; HGFB; Hepatopoietin A; hepatocyte growth factor; Fibroblast-D
Species:  
Rat
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P73928
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HGF; hepatocyte growth factor (Hepapoietin A; Scatter factor); Prev. DFNB39; Lung Fibroblast-Derived Mitogen; HPTA; Hepatopoietin-A; SF; Scatter factor; F-TCF; Deafness, Autosomal Recessive 39; HGFB; Hepatopoietin A; hepatocyte growth factor; Fibroblast-D
Species:  
Mouse
Source:  
HEK293
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1
1 Cited Publications
Cat. No.: HY-P72267
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MET; Soluble MET Variant 13; MET Proto-Oncogene, Receptor Tyrosine Kinase; Soluble MET Variant 14; hepatocyte growth factor Receptor; Soluble MET Variant 15; DFNB97; Soluble MET Variant 1; RCCP2; Soluble MET Variant 2; HGFR; Soluble MET Variant 3; Tyrosin
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P99391
CAS No.: 1781223-80-0
Synonyms: ABT-700; ABBV-400 Antibody

Target:  

c-Met/HGFR Apoptosis

Research Areas:  

Cancer

Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers .
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Cat. No.: HY-12423
CAS No.: 1190836-34-0
Purity:  98.28%
Synonyms: TAS-115
Target:  

VEGFR c-Met/HGFR

Research Areas:  

Cancer

Pamufetinib (TAS-115) is a potent VEGFR and hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively.
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Cat. No.: HY-137455
CAS No.: 1070881-42-3
Purity:  99.89%
Synonyms: ANG-3777
Target:  

c-Met/HGFR

Research Areas:  

Inflammation/Immunology

Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor .
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Cat. No.: HY-P99217
CAS No.: 872514-65-3
Synonyms: AMG 102

Target:  

c-Met/HGFR

Research Areas:  

Cancer

Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocyte growth factor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research .
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Cat. No.: HY-106961
CAS No.: 176391-41-6
Purity:  99.06%
Synonyms: ONO-AP 500-02
Research Areas:  

Cardiovascular Disease

ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .
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Cat. No.: HY-P99196
CAS No.: 1174900-84-5

Target:  

c-Met/HGFR

Research Areas:  

Cancer

Ficlatuzumab is a monoclonal antibody (McAb) targeting human hepatocyte growth factor (HGF). Ficlatuzumab blocks the activation of the HGF/c-Met signaling pathway, and inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion .
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Cat. No.: HY-106961A
CAS No.: 153814-74-5
Synonyms: (Z)-ONO-AP 500-02
Research Areas:  

Cardiovascular Disease

(Z)-ONO 1301 is the isomer of ONO 1301 (HY-106961), and can be used as an experimental control. ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .
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Cat. No.: HY-132814
CAS No.: 2093305-05-4
Purity:  98.24%
Synonyms: ATH-1017
Target:  

c-Met/HGFR

Research Areas:  

Neurological Disease

Fosgonimeton (ATH-1017) is a hepatocyte growth factor receptor (c-Met/HGFR) agonist. Fosgonimeton has neuroprotective effects in both LPS (HY-D1056) -induced neuroinflammation and Aβ-induced AD models .
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Cat. No.: HY-12423A
CAS No.: 1688673-09-7
Purity:  99.17%
Synonyms: TAS-115 mesylate
Target:  

VEGFR c-Met/HGFR

Research Areas:  

Cancer

Pamufetinib (TAS-115) mesylate is a potent VEGFRand hepatocyte growth factor receptor (c-Met/HGFR)-targeted kinase inhibitor, with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively.
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Cat. No.: HY-P2185A
Target:  

MMP

Research Areas:  

Others

NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
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