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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
human D2R
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "human D2R" in MCE Product Catalog:
Cat. No.: HY-14545B
CAS No.: 2974362-88-2
Target:
Research Areas:
SEP4199 is an orally active 5-HT7 receptor ligand, with a Ki value of 66 nM for human 5-HT7R and 16 nM for human D2R. SEP4199 mediates antidepressant effects. SEP4199 is applicable for the research of bipolar depression .
Cat. No.: HY-184589
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AB13-46A is a selective dopamine receptor agonist, with a Ki value of 0.505 nM against human D3R. AB13-46A can be used for research on nervous system-related diseases .
Cat. No.: HY-47412
CAS No.: 791778-53-5
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Cariprazine impurity 1 is a dopamine D2 receptor (D2R) agonist. Cariprazine impurity 1 modulates D2R-mediated Gi/o signaling pathway to inhibit cAMP production, and regulates D2R-mediated β-arrestin2 recruitment pathway .
Cat. No.: HY-184591
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AB13-73A is a highly selective partial agonist of dopamine D3R, with a Ki of 0.803 nM and a pEC50 of 11.88 (1.32 pM). AB13-73A serves as a pharmacological tool to dissect the (patho) physiological mechanisms of D3R and support the development of improved neurotherapeutic agents .
Cat. No.: HY-181049
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Research Areas:
FMJ-01-054 is a selective dopamine D4 Receptor (D4R) antagonist with a Ki od 77.7 nM. FMJ-01-054 shows subtype selectivity over D2R and D3R. FMJ-01-054 inhibits D4R-mediated β-arrestin recruitment and cAMP production with IC50 values of 3800 nM and 134 nM, respectively. FMJ-01-054 has desirable plasma half-life and brain exposure in rats. FMJ-01-054 can be used for the research of neurological disorders .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
