2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. SEP-4199

SEP4199 is an orally active 5-HT7 receptor ligand, with a Ki value of 66 nM for human 5-HT7R and 16 nM for human D2R. SEP4199 mediates antidepressant effects. SEP4199 is applicable for the research of bipolar depression.

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SEP-4199

SEP-4199 Chemical Structure

CAS No. : 2974362-88-2

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Other Forms of SEP-4199:

SEP-4199 Related Antibodies

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Description

SEP4199 is an orally active 5-HT7 receptor ligand, with a Ki value of 66 nM for human 5-HT7R and 16 nM for human D2R. SEP4199 mediates antidepressant effects. SEP4199 is applicable for the research of bipolar depression[1].

IC50 & Target[1]

D2 Receptor

16 nM (Ki)

5-HT7 Receptor

66 nM (Ki)

In Vitro

SEP4199 exhibits a higher relative affinity for human recombinant 5-HT7 receptors than human recombinant D2 receptors, with a 5-HT7R Ki of 66 ± 16 nM and a D2R Ki of 16 ± 0.62 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SEP-4199 Related Antibodies
Molecular Weight

369.48

Formula

C17H27N3O4S
CAS No.
SMILES

CCN1[C@@H](CNC(C2=CC(S(=O)(CC)=O)=C(N)C=C2OC)=O)CCC1.CCN3[C@H](CNC(C4=CC(S(=O)(CC)=O)=C(N)C=C4OC)=O)CCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SEP-4199 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SEP-41992974362-88-2SEP4199SEP 41995-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT7 receptor ligandbipolar depressionInhibitorinhibitorinhibit

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HY-14545B
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