20 Results for "

hypocholesterolemic

" in MedChemExpress (MCE) Product Catalog:
Products (20)

20 Results for "hypocholesterolemic" in MCE Product Catalog:

6
6 Cited Publications
Art. -Nr.: HY-100313A
CAS. Nr.: 182959-33-7
Reinheit:  98.23%
Forschungsgebiete:  

Infection Metabolic Disease

YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .
loading...
    loading...
Art. -Nr.: HY-134124
CAS. Nr.: 92614-59-0
Reinheit:  95.8%
Forschungsgebiete:  

Metabolic Disease

Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .
loading...
    loading...
Art. -Nr.: HY-125544
CAS. Nr.: 152755-31-2
Reinheit:  ≥98.0%
Synonyms: Agisterol
Target:  

LDLR

Forschungsgebiete:  

Metabolic Disease

LY 295427 is a LDL receptor modulator and a hypocholesterolemic agent. LY 295427 derepresses the transcription of the LDLR (LDL Receptor). LY 295427 can be used for hypercholesterolemia research .
loading...
    loading...
Art. -Nr.: HY-169813
CAS. Nr.: 81840-57-5
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC50 value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .
loading...
    loading...
Art. -Nr.: HY-100313
CAS. Nr.: 182959-28-0
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .
loading...
    loading...
Art. -Nr.: HY-120082
CAS. Nr.: 179054-51-4
Target:  

Acyltransferase

Forschungsgebiete:  

Metabolic Disease

FR-182980 is an orally active ACAT1 inhibitor (IC50: 30 nM). FR-182980 has hypocholesterolemic activity and can be used for research of atherosclerosis .
loading...
    loading...
Art. -Nr.: HY-107959
CAS. Nr.: 37296-80-3
Colestipol hydrochloride, a hypocholesterolemic bile acid‐binding anion‐exchange polymer, is used in the study of hypercholesterolaemia .
loading...
    loading...
Art. -Nr.: HY-Z8472
CAS. Nr.: 77517-29-4
Synonyms: Lovastatin EP impurity E; 4a,5-Dihydromevinolin
Dihydromevinolin is a potent hypocholesterolemic metabolite produced by Aspergillus terreus. Dihydromevinolin is a HMG-CoA reductase inhibitor .
loading...
    loading...
Art. -Nr.: HY-W015467
CAS. Nr.: 636-73-7
Synonyms: Pyridine-3-sulphonic acid
Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) is an orally active structural analog of Nicotine acid (HY-B0143). Pyridine-3-sulfonic acid significantly reduces hepatic cholesterol synthesis in rats but lacks cholesterol-lowering activity. Pyridine-3-sulfonic acid does not interfere with the metabolism of Nicotine acid .
loading...
    loading...
Art. -Nr.: HY-P2424
CAS. Nr.: 144396-38-3
Synonyms: CCK-J
Target:  

Calcium Channel

Forschungsgebiete:  

Others

Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca 2+ release .
loading...
    loading...
Art. -Nr.: HY-N5036
CAS. Nr.: 109008-26-6
Synonyms: Ilexoside K
Ilexsaponin B3 has significant hypocholesterolemic activity .
loading...
    loading...
Art. -Nr.: HY-117466
CAS. Nr.: 179053-90-8
Target:  

Acyltransferase

Forschungsgebiete:  

Metabolic Disease

FR186054 is an oral active acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor with the IC50 of 99 nM. FR186054 shows hypocholesterolemic effect and can be used for study of hypercholesterolemia and atherosclerosis .
loading...
    loading...
Art. -Nr.: HY-B1617AS
CAS. Nr.: 2714316-71-7
Zuclomiphene-d4 citrate is a deuterium labeled Zuclomiphene citrate (HY-B1617A). Zuclomiphene citrate is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene citrate is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene citrate can be for the researches of endocrinology and metabolic disease .
loading...
    loading...
Art. -Nr.: HY-P10872
Target:  

SARS-CoV

Forschungsgebiete:  

Infection

P315V3 is an pan inhibitor for coronavirus, that inhibits SARS-CoV-2 prototypePT, Delta, BA.1 and BA.4 strain with IC50s of 10.9, 8.9, 8.6, and 2.7 nM. P315V3 exhibits cytotoxicity in Vero cell with CC50 of 4.3 μM. P315V3 exhibits anti-infectious efficacy in mouse models .
loading...
    loading...
Art. -Nr.: HY-P10906
CAS. Nr.: 2868285-05-4
Forschungsgebiete:  

Others

Talovirtide is a peptide containing L-valyl .
loading...
    loading...
Art. -Nr.: HY-P11455
Target:  

Liposome

Forschungsgebiete:  

Others

Lipopeptide CPE4 is a PEG-modified peptide E4 [(EIAALEK) 4]. Lipopeptide CPE4 is capable of coiled-coil formation when attached to liposomes. Lipopeptide CPE4 triggers membrane fusion between liposomes and living cells with concomitant efficient cytosolic delivery of a variety of compounds such as fluorescent dyes Propidium Iodide (PI) (HY-D0815) and TO-PRO-3 iodide (HY-117070), and Doxorubicin (DOX) (HY-15142A). Lipopeptide CPE4 can be used for drug delivery research .
loading...
    loading...
Art. -Nr.: HY-156964
CAS. Nr.: 148-07-2
Forschungsgebiete:  

Cancer

Benzmalecene is a Krebs cycle inhibitor, and inhibits the active absorption of taurocholate by the small intestine in vivo and in vitro .
loading...
    loading...
Art. -Nr.: HY-19140
CAS. Nr.: 124884-99-7
Target:  

Acyltransferase

Forschungsgebiete:  

Metabolic Disease

YM17E hydrochloride is an acyl CoA:cholesterol acyltransferase (ACAT) inhibitor, with IC50 of 44 nM. YM17E hydrochloride has hypocholesterolemic effect .
loading...
    loading...
Art. -Nr.: HY-P11766
Synonyms: GALA-cholesterol
Forschungsgebiete:  

Cancer

GALA-chol is a cholesterol-conjugated pH-responsive fusion peptide that can serve as a delivery adjuvant. GALA-chol enhances the endocytosis of siRNA RET/PTC1-SQ nanoparticles, inhibits cell viability, and undergoes pH-responsive charge conversion in the acidic lysosomal environment, thereby promoting lysosomal escape of small extracellular vesicle (sEV) cargo. GALA-chol anchors to the sEV membrane and maintains the structural integrity and intrinsic homing activity of sEVs. GALA-chol can be used in studies related to adjuvant delivery .
loading...
    loading...
Art. -Nr.: HY-100313AR
CAS. Nr.: 182959-33-7
YM-53601 (Standard) is the analytical standard of YM-53601 (HY-100313A). This product is intended for research and analytical applications. YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent . YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .
loading...
    loading...
  • 1