Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
iPLA2
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "iPLA2" in MCE Product Catalog:
5
5 Cited Publications
Synonyms: Methyl Arachidonyl Fluorophosphonate
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
3
3 Cited Publications
Synonyms: (6E)-Bromoenol lactone
Target:
Research Areas:
Bromoenol lactone ((6E)-Bromoenol lactone) is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β) with an IC50 value of approximately 7 μM, which inhibits antigen-stimulated mast cell exocytosis without blocking Ca 2+ influx [2].
2
2 Cited Publications
Target:
Research Areas:
FKGK18 is a selective group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor. FKGK18 is a fluoroketone (FK)-based compound with IC50s of 50 nM and 3 μM for iPLA2β and iPLA2γ. FKGK18 can be used for the research of beta-cell apoptosis and diabetes [2] .
1
1 Cited Publications
Cat. No.: HY-P704076
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PNPLA3; Calcium-Independent Phospholipase A2-Epsilon; Prev. C22orf20; Acylglycerol Transacylase; Prev. ADPN; iPLA2-Epsilon; Adiponutrin; DJ796I17.1; Patatin Like Domain 3, 1-Acylglycerol-3-Phosphate O-Acyltransferase; FLJ22012; Patatin-Like Phospholipase
Species:
Human
Source:
Sf9 insect cells
Synonyms: (S)-BEL; (S,E)-Bromoenol lactone
Target:
Research Areas:
(S)-Bromoenol lactone ((S)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase A2β (iPLA2β) that inhibits the vasopressin-induced release of arachidonate from cultured rat aortic smooth muscle (A10) cells with an IC50 of 2 µM .
Cat. No.: HY-W127380
CAS No.: 146797-82-2
Cat. No.: HY-116018
CAS No.: 1071000-98-0
Target:
Research Areas:
FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis [2].
Cat. No.: HY-129944
CAS No.: 199106-13-3
Target:
Research Areas:
MJ33-OH is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .
Target:
Research Areas:
GK187 is a potent and selective Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor with an XI(50) value of 0.0001. GK187 can be used for researching various neurological disorders .
[The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]
[The XI(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]
Cat. No.: HY-117068
CAS No.: 478288-90-3
Synonyms: (R,E)-Bromoenol lactone
Target:
Research Areas:
(R)-Bromoenol lactone ((R,E)-Bromoenol lactone) is an isomer of Bromoenol lactone (HY-107411). (R)-Bromoenol lactone acts as a selective inhibitor of microsomal calcium-independent phospholipase A2γ (iPLA2γ). (R)-Bromoenol lactone induces mild activation of p38 mitogen-activated protein kinase in prostate cancer cells, resulting in slight increases in the expressions of phosphorylated p53, total p53 and p21. (R)-Bromoenol lactone is applicable to prostate cancer-related research .
Cat. No.: HY-129944A
CAS No.: 1135306-36-3
Target:
Research Areas:
MJ33-OH lithium is a metabolite of MJ33. MJ33 is an active-site-directed, specific, competitive, and reversible phospholipase A2 (PLA2) inhibitor. MJ33 blocks the calcium-independent phospholipase A2 (iPLA2) activity of Prdx6 .
Cat. No.: HY-138990
CAS No.: 2351820-19-2
Target:
Research Areas:
GK563 is a selective Ca 2+-independent phospholipase A2 (GVIA iPLA2) inhibitor with an IC50 value of 1 nM. GK563 is 22000 times more active against GVIA iPLA2 than GIVA cPLA2. GK563 reduces β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes .
Cat. No.: HY-126072
CAS No.: 1983928-04-6
Target:
Research Areas:
(Rac)-GK563 is the isomer of GK563 (HY-138990). GK563 is a Ca 2+-independent group VI phospholipase A2 (GVIA iPLA2) inhibitor .
Cat. No.: HY-103334R
CAS No.: 188404-10-6
Synonyms: Methyl Arachidonyl Fluorophosphonate (Standard)
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease
MAFP (Standard) is the analytical standard of MAFP (HY-103334). This product is intended for research and analytical applications. MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
Cat. No.: HY-RS10633
Target:
Research Areas:
PLA2G6 Human Pre-designed siRNA Set A contains three designed siRNAs for PLA2G6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-117068S
Synonyms: (R,E)-Bromoenol lactone-d7
Research Areas:
(R)-Bromoenol lactone-d7 ((R,E)-Bromoenol lactone-d7) is the deuterated-labeled (R)-Bromoenol lactone (HY-117068). (R)-Bromoenol lactone ((R,E)-Bromoenol lactone) is an isomer of Bromoenol lactone (HY-107411). (R)-Bromoenol lactone acts as a selective inhibitor of microsomal calcium-independent phospholipase A2γ (iPLA2γ). (R)-Bromoenol lactone induces mild activation of p38 mitogen-activated protein kinase in prostate cancer cells, resulting in slight increases in the expressions of phosphorylated p53, total p53 and p21. (R)-Bromoenol lactone is applicable to prostate cancer-related research .
Cat. No.: HY-P71600
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PNPLA2; iPLA2-Zeta; Patatin Like Domain 2, Triacylglycerol Lipase; PEDF-R; Adipose Triglyceride Lipase; TTS2.2; Desnutrin; TTS2; ATGL; Patatin-Like Phospholipase Domain Containing 2 Variant; Patatin-Like Phospholipase Domain-Containing Protein 2; Patatin-
Species:
Human
Source:
E. coli
Cat. No.: HY-P704075
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PNPLA3; Calcium-Independent Phospholipase A2-Epsilon; Prev. C22orf20; Acylglycerol Transacylase; Prev. ADPN; iPLA2-Epsilon; Adiponutrin; DJ796I17.1; Patatin Like Domain 3, 1-Acylglycerol-3-Phosphate O-Acyltransferase; FLJ22012; Patatin-Like Phospholipase
Species:
Human
Source:
HEK293
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
