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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
31 Results for "
membrane sterols
" in MedChemExpress (MCE) Product Catalog:
Products (31)
31 Results for "membrane sterols" in MCE Product Catalog:
95
95
95 Publications Verification
Cat. No.: HY-N0322A
Target:
(Note: This product is a mixture of Cholesterol and Methyl-β-cyclodextrin. The product specifications below only indicate the effective content of Cholesterol.)
57
57 Cited Publications
Cat. No.: HY-N6716
CAS No.: 11078-21-0
Category:
Microorganisms Antifungal Antibiotics Other Diseases Antiviral Disease Research Disease Research Fields Other Antibiotics
Target:
27
Category:
Microorganisms Antifungal Antibiotics Disease Research Disease Research Fields Inflammation/Immunology Other Antibiotics
Target:
14
Cholesterol (synthetic) is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol (synthetic) plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins . Cholesterol (synthetic) is also an endogenous estrogen-related receptor α (ERRα) agonist .
14
1
1 Cited Publications
Cat. No.: HY-N0322S4
1
1 Cited Publications
Cat. No.: HY-N0322S6
CAS No.: 956029-28-0
1
1 Cited Publications
Target:
Research Areas:
Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi?in vitro?and?in vivo . Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis .
Cat. No.: HY-N0322S
CAS No.: 83199-47-7
Cat. No.: HY-N0322S5
CAS No.: 78887-48-6
Synonyms: BAY-W-6341
Abafungin (BAY-W-6341) is a broad-spectrum fungicidal arylguanidine compound and a selective inhibitor of sterol-C-24-methyltransferase. Abafungin blocks the transmethylation reaction at the C-24 position of the sterol side chain during the ergosterol biosynthesis pathway. Abafungin directly disrupts fungal cell membrane integrity, and diminishes fungal viability independent of the fungal growth state. Abafungin can be applied to the research of fungal infections, particularly dermatomycoses .
Cat. No.: HY-N0322S1
CAS No.: 60816-17-3
Cat. No.: HY-N0322S2
CAS No.: 92543-08-3
Cat. No.: HY-N0322S7
CAS No.: 51467-57-3
Cat. No.: HY-DY1017
CAS No.: 11078-21-0
Solvent and concentration: DMSO: 5 mg/mL
Target:
Research Areas:
Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells .
Cat. No.: HY-121012
CAS No.: 442656-02-2
Research Areas:
(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway .
Cat. No.: HY-N0322S3
CAS No.: 150044-24-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
