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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
mycelial morphology
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "mycelial morphology" in MCE Product Catalog:
Cat. No.: HY-179287
Research Areas:
SDH-IN-42 (Compound D28) is a SDH (IC50: 5.38 μg/mL) inhibitor and antifungal agent. SDH-IN-42 exerts antifungal activity against R. solani by disrupting mycelial morphology, increasing cell membrane permeability, inducing the production and accumulation of ROS, and impairing mitochondrial function .
Cat. No.: HY-149614
CAS No.: 2991094-41-6
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Cat. No.: HY-176552
Target:
Research Areas:
Tubulin polymerization-IN-83 (Compound A23) is a flavonol derivative. Tubulin polymerization-IN-83 exhibits antifungal activity against various phytopathogenic fungi, with an EC50 of 0.338 μg/mL against Botrytis cinerea. Tubulin polymerization-IN-83 exerts its effects by targeting β-tubulin, disrupting mycelial morphology, and increasing cell membrane permeability, with relatively low ecological and environmental risks .
Cat. No.: HY-176413
SDH-IN-27 (Compound Q18) is a succinate dehydrogenase inhibitor (SDHI) (IC50: 9.7 mg/L). SDH-IN-27 induces mycelial morphology changes and lipid peroxidation, and exhibits antifungal activity against C. camelliae (EC50: 6.0 mg/L). SDH-IN-27 is an ergosterol biosynthesis inhibitor (EBI) that binds to the active site of CYP51, ultimately leading to cell death of pathogenic fungi .
Cat. No.: HY-181610
CAS No.: 3112883-32-3
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Research Areas:
SDH-IN-45 is a succinate dehydrogenase BcSDH inhibitor and mycelial growth inhibitor targeting Botrytis cinerea, with an IC50 of 5.97 μg/mL against Botrytis cinerea. SDH-IN-45 inhibits succinate dehydrogenase, a component of the mitochondrial electron transport chain, via a unique binding mode, thereby regulating fungal energy metabolism. SDH-IN-45 causes morphological damage to Botrytis cinerea mycelia, leading to collapse and shrinkage of mycelial structures. SDH-IN-45 exhibits in vitro fungicidal activity against Botrytis cinerea. SDH-IN-45 can be used in research related to cucumber gray mold .
Cat. No.: HY-189457
SDH-IN-52 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 0.30 μM) and antifungal agent. SDH-IN-52 inhibits SDH enzyme activity in Rhizoctonia solani, interferes with fungal mitochondrial electron transport, and disrupts mycelial morphology; it exhibits protective and curative effects on rice leaves and is suitable for research related to rice sheath blight and Rhizoctonia solani infection .
Cat. No.: HY-170974
SDH-IN-20 (compound A19) is an antifungal agent. SDH-IN-20 against Verticillium dahlia, R. solani with EC50s of less than 3.0 μg/mL, 2.87 μg/mL. SDH-IN-20 exerts its highly antifungal effects by acting as an effective succinate dehydrogenase (SDH) inhibitor with an IC50 of 29.33 μM. SDH-IN-20 adversely impacts the integrity of cell membranes and mycelial morphologies of R. solani .
Cat. No.: HY-187993
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SDH-IN-47 is a succinate dehydrogenase (SDH) inhibitor, with an IC50 value of 1.80 μM against SDH from Botrytis cinerea. SDH-IN-47 binds to the active site of SDH, interferes with fungal growth, disrupts mycelial morphology and cell membrane integrity, and induces depolarization of mitochondrial membrane potential. SDH-IN-47 exhibits in vitro and in vivo antifungal activities against a variety of plant pathogenic fungi, including Botrytis cinerea, Phytophthora capsici, and Valsa mali, and can be used for studies on related fungal infections .
Cat. No.: HY-189425
Target:
Research Areas:
SDH-IN-51 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.16 μM against Rhizoctonia solani. SDH-IN-51 inhibits succinate dehydrogenase in the fungal mitochondrial respiratory chain, disrupting energy production. SDH-IN-51 disrupts fungal cell wall or membrane integrity, leading to mycelial morphological abnormalities. SDH-IN-51 exhibits protective and curative antifungal efficacy against Rhizoctonia solani on rice leaves in detached leaf assays. SDH-IN-51 can be used for research on rice sheath blight .
Cat. No.: HY-189346
Myosin I-IN-1 is an Antifungal agent and Myosin I inhibitor with a Kd of 0.14 μM for FgMyoI. Myosin I-IN-1 inhibits mycelial growth, sporulation, spore germination, and Deoxynivalenol (HY-N6684) biosynthesis. Myosin I-IN-1 disrupts cell wall and cell membrane integrity and induces hyphal morphological changes. Myosin I-IN-1 exhibits broad-spectrum antifungal activity against plant pathogenic fungi. Myosin I-IN-1 shows protective efficacy against Fusarium head blight in wheat and maize. Myosin I-IN-1 can be used for research on Fusarium head blight .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
