94 Results for "

nuclear factor kappa B

" in MedChemExpress (MCE) Product Catalog:
Products (94)

94 Results for "nuclear factor kappa B" in MCE Product Catalog:

17
17 Publications Verification
Cat. No.: HY-P7425
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of nuclear factor kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of nuclear factor kappa B Ligand; OPGL; Tumor Necrosis factor Ligand
Species:  
Mouse
Source:  
E. coli
loading...
    loading...
10
10 Cited Publications
Cat. No.: HY-P7424
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of nuclear factor kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of nuclear factor kappa B Ligand; OPGL; Tumor Necrosis factor Ligand
Species:  
Human
Source:  
E. coli
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-P73388
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of nuclear factor kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of nuclear factor kappa B Ligand; OPGL; Tumor Necrosis factor Ligand
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-N6769
CAS No.: 12772-57-5
Synonyms: Monorden
Radicicol is an inhibitor of Hsp90 with an IC50 value < 1 μM, and leads to proteasomal degradation . Radicicol exhibits inhibition on PDK with IC50s of 230 μM (PDK1) and 400 μM (PDK3). Radicicol is an antifungal and antimalarial antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB . Radicicol is also an inhibitor of fat mass and obesity-associated protein (FTO), with an IC50 value of 16.04 μM .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-P73386
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of nuclear factor kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of nuclear factor kappa B Ligand; OPGL; Tumor Necrosis factor Ligand
Species:  
Human
Source:  
HEK293
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P9958
CAS No.: 615258-40-7
Synonyms: AMG-162

Research Areas:  

Endocrinology Cancer

Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (KD of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-N6871
CAS No.: 514-10-3
Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P9958A
CAS No.: 615258-40-7
Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (KD of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-N2106
CAS No.: 67909-49-3
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P73681
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: RELA; NF-kappa-B Transcription factor P65; Prev. NFKB3; P65 Iso5 Isoform Delta 10; nuclear factor Of kappa Light Polypeptide Gene Enhancer In B-Cells 3; Alternative Protein RELA; P65; NF-kappa-B P65delta3; V-Rel Avian Reticuloendotheliosis Viral Oncogene
Species:  
Human
Source:  
E. coli
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-P81238
Synonyms: Phospho-NF-KB p65 (Ser536) ; NF-kB p65 (phospho S536); p-NF-κB p65(Phospho-Ser536); RELA(phospho S536); NF kB P65; NF-kB p65; NFKBp65; NF-κBp65; p65 NF kappaB; p65 NFkB; NFKBp65; RELA; Transcription factor p65; v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)); V Rel Avian Reticuloendotheliosis Viral Oncogene Homolog A; v rel reticuloendotheliosis viral oncogene homolog A (avian); v-rel reticuloendotheliosis viral oncogene homolog A; p65NFKB; Avian reticuloendotheliosis viral (v rel) oncogene homolog A; MGC131774; NFKB 3; NFKB3; nuclear factor NF kappa B p65 Subunit; nuclear factor of kappa light polypeptide gene enhancer in B cells 3; nuclear factor Of kappa Light Polypeptide Gene Enhancer In B Cells; TF65_HUMAN. NFκB-p65; NFκB p65; NF κB-p65; NFκBp65;

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat, Monkey

loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-N0632
CAS No.: 65497-07-6
Esculentoside A (EsA), a kind of triterpene saponin isolated from roots of Phytolacca esculenta . Esculentoside A (EsA) possesses anti-inflammatory activity in acute and chronic experimental models , has selective inhibitory activity towards cyclooxygenase-2 (COX-2) . Esculentoside A (EsA) suppresses inflammatory responses in LPS-induced acute lung injury (ALI) through inhibition of the nuclear factor kappa B (NF-ΚB) and mitogen activated protein kinase (MAPK) signaling pathways .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P80470
Synonyms: NFKB3, RELA, Transcription factor p65, nuclear factor NF-kappa-B p65 subunit, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3

Host:  

Rabbit

Application:  

WB, IP, FC, IHC-P

Reactivity:  

Human

loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-B1051
CAS No.: 2135-17-3
Synonyms: Flumetasone
Flumethasone (Flumetasone) is an orally active, high selective and potent glucocorticoid receptor (GR) agonist. Flumethasone activates GR to inhibit nuclear factor kappa B (NF-κB)-mediated pro-inflammatory cytokine production (TNF-α, IL-1β) and promotes anti-inflammatory gene expression (IL-10), while also regulating metabolic enzyme activity (tyrosine aminotransferase induction). Flumethasone is promising for research of inflammatory diseases, cancer, and endocrine regulation .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-N0381
CAS No.: 19908-48-6
Synonyms: DL-​Maackiain
Maackiain (DL-Maackiain) is an orally active multi-target inhibitor with anti-tumor activity and neuroprotective effects. Maackiain activates the AMPK, NLRP3 and Nrf2/HO-1 pathways, and inhibits key targets such as NF-κB, mTOR, MAO-B, NFATc1 and PKCδ, thereby precisely regulating processes including apoptosis, autophagy and pyroptosis. Maackiain also effectively inhibits microglial activation, osteoclast formation, and proliferation and invasion of tumor cells, and protects dopaminergic neurons from damage. Maackiain is applicable to the research of various diseases such as Alzheimer's disease, osteoporosis, sepsis and dengue fever 。
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-122308
CAS No.: 58139-23-4
Purity:  99.94%
Militarine is a plant growth inhibitor and anti-inflammatory agent. Militarine inhibits the elongation of radicles and hypocotyls in seedlings of lettuce, Italian ryegrass and timothy grass. Militarine alleviates PM2.5-induced inflammatory injury and inhibits cell migration in human alveolar epithelial A549 cells by inhibiting the NF-κB signaling pathway, reducing oxidative stress and the release of inflammatory factors. Militarine can be used in studies related to PM2.5-induced pulmonary diseases .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P701786
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IKBKB; IKK-2; Inhibitor Of nuclear factor kappa B Kinase Subunit Beta; CDNA FLJ33978 Fis, Clone DFNES2004354, Highly Similar To Inhibitor Of nuclear factor kappa B Kinase Subunit Beta; IKK-Beta; Inhibitor Of kappa Light Polypeptide Gene Enhancer In B-Cell
Species:  
Human
Source:  
Sf9 insect cells
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P700226AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of nuclear factor kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of nuclear factor kappa B Ligand; OPGL; Tumor Necrosis factor Ligand
Species:  
Mouse
Source:  
E. coli
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P7425B
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of nuclear factor kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of nuclear factor kappa B Ligand; OPGL; Tumor Necrosis factor Ligand
Species:  
Mouse
Source:  
HEK293
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P81124
Synonyms: OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.

Host:  

Rabbit

Application:  

WB, IHC-P, ELISA

Reactivity:  

Human, Mouse, Rat

loading...
    loading...