2135-17-3
Chemical Structure
Flumethasone
Synonym(s): Flumetasone
- CAS No.: 2135-17-3
- Formula:C22H28F2O5
- Molecular Weight:410.45
IUPAC Name: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChIKey: WXURHACBFYSXBI-GQKYHHCASA-N
SMILES: C[C@@]12[C@](C(CO)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
Biological Activity: Flumethasone (Flumetasone) is an orally active, high selective and potent glucocorticoid receptor (GR) agonist. Flumethasone activates GR to inhibit nuclear factor kappa B (NF-κB)-mediated pro-inflammatory cytokine production (TNF-α, IL-1β) and promotes anti-inflammatory gene expression (IL-10), while also regulating metabolic enzyme activity (tyrosine aminotransferase induction). Flumethasone is promising for research of inflammatory diseases, cancer, and endocrine regulation[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Flumethasone | 99.84% | Flumethasone (Flumetasone) is an orally active, high selective and potent glucocorticoid receptor (GR) agonist. Flumethasone activates GR to inhibit nuclear factor kappa B (NF-κB)-mediated pro-inflammatory cytokine production (TNF-α, IL-1β) and promotes anti-inflammatory gene expression (IL-10), while also regulating metabolic enzyme activity (tyrosine aminotransferase induction). Flumethasone is promising for research of inflammatory diseases, cancer, and endocrine regulation. | ||||||||||||||||||||
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Flumethasone (Standard) | 99.45% | Flumethasone (Standard) is the analytical standard of Flumethasone. This product is intended for research and analytical applications. Flumethasone is a corticosteroid, a topical agent used in combination with Clioquinol for the study of otitis externa and otomycosis. When used in animal models, Flumethasone's anti-inflammatory activity is 420 times higher than that of Cortisone. | ||||||||||||||||||||
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- [1]. Zhou Y, et al. Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway. Cancer Lett. 2020 Apr 1;474:94-105. [Content Brief]
- [2]. Blake RL. Flumethasone induction of liver tyrosine aminotransferase activity in inbred strains and obese mutant mice. Biochem Pharmacol. 1970 May;19(5):1803-15. [Content Brief]
- [3]. Bednarek D, et al. The effect of steroidal and non-steroidal anti-inflammatory drugs on the cellular immunity of calves with experimentally-induced local lung inflammation. Vet Immunol Immunopathol. 1999 Oct 1;71(1):1-15. [Content Brief]
- [4]. Willi RA, et al. Environmental glucocorticoids corticosterone, betamethasone and flumethasone induce more potent physiological than transcriptional effects in zebrafish embryos. Sci Total Environ. 2019 Jul 1;672:183-191. [Content Brief]
Keywords
