6β-Hydroxy dexamethasone

Cat. No.: HY-137197 Purity: 99.03%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

6β-Hydroxy dexamethasone is an active metabolite of the synthetic glucocorticoid Dexamethasone (HY-14648).

For research use only. We do not sell to patients.

6β-Hydroxy dexamethasone Chemical Structure

CAS No. : 55879-47-5

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

6β-Hydroxy dexamethasone is an active metabolite of the synthetic glucocorticoid Dexamethasone (HY-14648)^[1].

Molecular Weight

408.46

Formula

C₂₂H₂₉FO₆

CAS No.

55879-47-5

Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C[C@]2(C([C@@H](C[C@@]3([C@@]2([C@H](C[C@]4([C@]3(C[C@H]([C@@]4(C(CO)=O)O)C)[H])C)O)F)[H])O)=C1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (122.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4482 mL	12.2411 mL	24.4822 mL
5 mM	0.4896 mL	2.4482 mL	4.8964 mL
10 mM	0.2448 mL	1.2241 mL	2.4482 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.03%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (255 KB) HNMR (279 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Gentile DM, et al. Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation. J Pharmacol Exp Ther. 1996 Apr;277(1):105-12. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4482 mL	12.2411 mL	24.4822 mL	61.2055 mL
	5 mM	0.4896 mL	2.4482 mL	4.8964 mL	12.2411 mL
	10 mM	0.2448 mL	1.2241 mL	2.4482 mL	6.1206 mL
	15 mM	0.1632 mL	0.8161 mL	1.6321 mL	4.0804 mL
	20 mM	0.1224 mL	0.6121 mL	1.2241 mL	3.0603 mL
	25 mM	0.0979 mL	0.4896 mL	0.9793 mL	2.4482 mL
	30 mM	0.0816 mL	0.4080 mL	0.8161 mL	2.0402 mL
	40 mM	0.0612 mL	0.3060 mL	0.6121 mL	1.5301 mL
	50 mM	0.0490 mL	0.2448 mL	0.4896 mL	1.2241 mL
	60 mM	0.0408 mL	0.2040 mL	0.4080 mL	1.0201 mL
	80 mM	0.0306 mL	0.1530 mL	0.3060 mL	0.7651 mL
	100 mM	0.0245 mL	0.1224 mL	0.2448 mL	0.6121 mL