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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
553 Results for "
nuclear protein
" in MedChemExpress (MCE) Product Catalog:
Products (553)
553 Results for "nuclear protein" in MCE Product Catalog:
212
212 Publications Verification
Cat. No.: HY-B0579
CAS No.: 59865-13-3
Synonyms: Cyclosporine A; Ciclosporin A; CsA
76
25
Target:
Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle .
20
Lenacapavir (GS-6207) is an HIV-1 capsid inhibitor. Lenacapavir binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .
20
Lenacapavir (GS-6207) sodium is an HIV-1 capsid inhibitor. Lenacapavir sodium binds to the interface between capsid hexamers and CA monomers, disrupts capsid assembly and viral maturation, inhibits nuclear translocation of HIV-1 DNA, interferes with CA-mediated protein-protein interactions, reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and decreases the production of mature HIV-1. Lenacapavir sodium exhibits activity against a variety of HIV-1 subtypes and clinical isolates. Lenacapavir sodium is applicable to research related to human immunodeficiency virus type 1 (HIV-1) infection .
17
17 Cited Publications
Cat. No.: HY-P7425
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of nuclear Factor Kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of nuclear Factor Kappa B Ligand; OPGL; Tumor Necrosis Factor Ligand
Species:
Mouse
Source:
E. coli
14
14 Cited Publications
Cat. No.: HY-P7218
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL33; DVS27-Related protein; Prev. C9orf26; Chromosome 9 Open Reading Frame 26 (NF-HEV); NF-HEV; Interleukin-1 Family, Member 11; IL1F11; Alternative protein IL33; Interleukin-33; IL-1F11; DVS27; NFEHEV; nuclear Factor From High Endothelial Venules; IL-33
Species:
Mouse
Source:
E. coli
12
Target:
Research Areas:
ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity .
11
10
10 Cited Publications
Cat. No.: HY-P7424
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of nuclear Factor Kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of nuclear Factor Kappa B Ligand; OPGL; Tumor Necrosis Factor Ligand
Species:
Human
Source:
E. coli
6
6 Cited Publications
Research Areas:
XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections .
6
6 Cited Publications
Cat. No.: HY-P70570
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding protein; Prev. HMG1; Amphoterin; High Mobility Group protein B1; HMG-1; High Mobility Group protein 1; nuclear Dot-Associated Sp100 protein; SBP-1; nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Human
Source:
E. coli
6
6 Cited Publications
Cat. No.: HY-P73388
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNFSF11; Tumor Necrosis Factor (Ligand) Superfamily, Member 11; TNF Superfamily Member 11; Receptor Activator Of nuclear Factor Kappa-B Ligand; TRANCE; TNLG6B; RANKL; Receptor Activator Of nuclear Factor Kappa B Ligand; OPGL; Tumor Necrosis Factor Ligand
Species:
Mouse
Source:
HEK293
5
5 Cited Publications
Cat. No.: HY-P73104
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding protein; Prev. HMG1; Amphoterin; High Mobility Group protein B1; HMG-1; High Mobility Group protein 1; nuclear Dot-Associated Sp100 protein; SBP-1; nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Mouse
Source:
HEK293
5
5 Cited Publications
Cat. No.: HY-N0034
CAS No.: 20362-31-6
Synonyms: Arctii; NSC 315527; Arctigenin-4-glucoside
Category:
Anti-aging Lignans Phenylpropanoids Plants Compositae Caesalpinia magnifoliolata Metc. Disease Research Fields Cancer
Target:
5
5 Cited Publications
Cat. No.: HY-N5124
CAS No.: 60767-80-8
Synonyms: Isovitexin 2''-O-glucoside; Isovitexin 2''-O-β-D-glucoside
5
PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle . CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.
5
4
4 Cited Publications
Synonyms: CB-1348; WR-139013
Target:
Research Areas:
Chlorambucil (CB-1348), an orally active antineoplastic agent, is a CNS-penetrant bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .
4
4 Cited Publications
Cat. No.: HY-P73104A
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: HMGB1; Sulfoglucuronyl Carbohydrate Binding protein; Prev. HMG1; Amphoterin; High Mobility Group protein B1; HMG-1; High Mobility Group protein 1; nuclear Dot-Associated Sp100 protein; SBP-1; nuclear Autoantigen Sp-100; HMG3; High-Mobility Group Box 1; Hi
Species:
Mouse
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
