Search Result

Pathways Recommended:	Vitamin D Related/Nuclear Receptor

Results for "

nuclear protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NF-κB (22) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (2) Orphan Nuclear Receptor (1) Acyltransferase (1) ADC Linker (1) Akt (3) AMPK (2) Amyloid-β (4) Androgen Receptor (5) Antibiotic (7) AP-1 (1) Apoptosis (28) Aryl Hydrocarbon Receptor (1) Autophagy (3) AUTOTACs (2) Bacterial (4) Bcl-2 Family (8) Beclin1 (1) Beta-secretase (2) Biochemical Assay Reagents (5) CaMK (1) Carbonic Anhydrase (1) Caspase (10) Cathepsin (1) CDK (6) Ceramidase (1) Cholinesterase (ChE) (4) CMV (1) Constitutive Androstane Receptor (1) COX (6) CRM1 (5) Cyclin G-associated Kinase (GAK) (1) DAPK (1) Dengue Virus (1) Deubiquitinase (3) DNA Alkylator/Crosslinker (2) DNA Methyltransferase (2) DNA-PK (1) DNA/RNA Synthesis (9) Dopamine Transporter (1) Drug Derivative (4) Drug Isomer (1) E1/E2/E3 Enzyme (1) EBV (1) Endogenous Metabolite (10) Environmental Pollutants (2) Epigenetic Reader Domain (3) ERK (7) Estrogen Receptor/ERR (3) Eukaryotic Initiation Factor (eIF) (1) FAK (1) Fatty Acid Synthase (FASN) (1) FKBP (2) Fluorescent Dye (3) Fungal (1) GABA Receptor (1) GLUT (1) Glycosidase (2) Heme Oxygenase (HO) (1) Herbicide (1) HIF/HIF Prolyl-Hydroxylase (2) Hippo (MST) (1) Histone Demethylase (2) Histone Methyltransferase (10) HIV (7) HSP (3) HSV (1) IAP (1) IKK (2) Influenza Virus (3) Insecticide (4) Interleukin Related (10) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (4) JAK (1) JNK (3) Kallikrein (1) Keap1-Nrf2 (19) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (2) MEK (1) Microtubule/Tubulin (1) Mineralocorticoid Receptor (1) MMP (5) Molecular Glues (5) Monoamine Oxidase (1) mRNA (11) mTOR (3) MyD88 (1) NO Synthase (3) NOD-like Receptor (NLR) (2) Notch (1) OGT (1) P2Y Receptor (3) p38 MAPK (7) Parasite (4) PARP (2) PERK (2) PGE synthase (1) Phosphatase (3) Phospholipase (3) PI3K (2) PKC (3) Potassium Channel (1) PPAR (4) PROTACs (8) Pyroptosis (1) Pyruvate Kinase (2) Quinone Reductase (1) RANKL/RANK (2) RAR/RXR (1) Ras (5) Reactive Oxygen Species (ROS) (9) Reference Standards (11) RSV (1) SARS-CoV (2) SNIPERs (1) STAT (4) Survivin (1) Syk (1) Tau Protein (1) TGF-beta/Smad (1) TGF-β Receptor (2) Thymidylate Synthase (1) TNF Receptor (5) Toll-like Receptor (TLR) (1) Virus Protease (1) WDR5 (1) YAP (1) α-synuclein (1)
By Research Areas:	Cancer (102) Cardiovascular Disease (14) Endocrinology (3) Infection (32) Inflammation/Immunology (43) Metabolic Disease (18) Neurological Disease (23)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Aptamers (1) Transcription Factors (4) mRNA (11) Gene Editing (5)

181

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

124

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Neomycin sulfate Maximum Cited Publications 68 Publications Verification	Environmental Pollutants Antibiotic Phospholipase Bacterial	Infection Metabolic Disease Cancer
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer .

Leptomycin B 20+ Cited Publications CI 940; LMB	CRM1 Fungal Antibiotic	Infection Cancer
Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle .

Cytochrome C (bovine heart)	Biochemical Assay Reagents Apoptosis Reactive Oxygen Species (ROS) Caspase	Metabolic Disease
Cytochrome C (bovine heart) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (bovine heart) acts as an effective ROS scavenger, but when combined with the cofactor p66Shc, it promotes the generation of ROS to initiate apoptosis. Cytochrome C (bovine heart) can act as a single electron carrier .

Denosumab 2 Publications Verification AMG-162	NF-κB Caspase Apoptosis RANKL/RANK	Endocrinology Cancer
Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the *receptor activator of nuclear* factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB** pathway. Denosumab can be used in bone-related studies .

Arctiin 5 Publications Verification Arctii; NSC 315527; Arctigenin-4-glucoside	NF-κB	Inflammation/Immunology Cancer
Arctiin is an orally active inhibitor of NF-κB. Arctiin suppresses cyclin D1 protein expression in human tumor cells. Arctiin also reduces malondialdehyde and pro-in ammatory cytokines levels. Arctiin can used in study glomerulonephritis .

AS 1411 2 Publications Verification AGRO-100	Histone Methyltransferase Bcl-2 Family	Cancer
AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .

XL177A 5 Publications Verification	Deubiquitinase Histone Demethylase SARS-CoV	Cancer
XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the *ELOF1-UVSSA-USP7*-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections .

ML334 10+ Cited Publications LH601A	Quinone Reductase Keap1-Nrf2	Cancer
ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity .

Cytochrome C (equine heart)	Biochemical Assay Reagents Apoptosis Caspase	Metabolic Disease
Cytochrome C (equine heart) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (equine heart) is involved in mitochondrial electron transport and intrinsic type II apoptosis. Cytochrome C (equine heart) can act as a single electron carrier .

Ibetazol	Ras	Cancer
Ibetazol is a Importin β1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin β1, blocks both Importin β1-mediated direct transport and Importin α-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin α1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, RelA/p65 and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin β1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin β1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin β1 .

PRLX-93936	Molecular Glues Ras Apoptosis HIF/HIF Prolyl-Hydroxylase	Cancer
PRLX-93936 is a molecular Glues that binds to and reprograms the TRIM21 ubiquitin ligase to degrade nuclear pore complexes. PRLX-93936 binds to TRIM21, forms a ternary complex with TRIM21 and NUP98, and mediates the ubiquitination and proteasomal degradation of NUP98 and other nuclear pore complex proteins. PRLX-93936 induces the loss of short-lived cytoplasmic mRNA transcripts, triggers cancer cell apoptosis (Apoptosis), and inhibits the activated Ras pathway. PRLX-93936 inhibits HIF-1 under hypoxic conditions (IC₅₀ = 0.09 μM in cell-based reporter gene assay). PRLX-93936 suppresses tumor growth in mouse models and improves survival rates in mouse models of multiple myeloma. PRLX-93936 is applicable to research related to pancreatic cancer and multiple myeloma .

Verdinexor 2 Publications Verification KPT-335	CRM1 Apoptosis RSV	Infection Inflammation/Immunology Cancer
Verdinexor (KPT-335) is an orally active inhibitor for *selective inhibitor of nuclear* export (SINE). Verdinexor inhibits the respiratory syncytial virus A2 (RSV A2) replication with an IC₅₀** of 0.96 µM. Verdinexor inhibits the function of nuclear export protein Exportin 1 (XPO1/CRM1), inhibiting pro-inflammatory responses. Verdinexor exhibits antitumor effciency .

Chlorambucil 4 Publications Verification CB-1348; WR-139013	DNA Alkylator/Crosslinker	Neurological Disease Cancer
Chlorambucil (CB-1348), an orally active antineoplastic agent, is a CNS-penetrant bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease .

Neomycin	Antibiotic Phospholipase	Infection Cancer
Neomycin, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin is a known phospholipase C (PLC) inhibitor. Neomycin potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin inhibits IP3-mediated Ca ²⁺ release, MgATP-dependent Ca ²⁺ uptake, and electrical excitation-evoked skeletal muscle Ca ²⁺ transients. Neomycin depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin can be used for the research of cancer .

Avrainvillamide (+)-Avrainvillamide; CJ-17,665	Antibiotic	Infection Cancer
Avrainvillamide ((+)-Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic, inhibits growth of multi-agent resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively .

NICE-01 AP1867-PEG2-JQ1; AP-PEG2-JQ1	Epigenetic Reader Domain	Others
NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that bind to proteins in separate cellular compartments that can induce nuclear import of cytosolic cargoes, using nuclear-localized bromodomain-containing protein 4 (BRD4) as a “carrier” for co-import and nuclear trapping of cytosolic proteins .

NLS (PKKKRKV) 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the SV40 large T antigen, which mediates the binding of karyophilic proteins to importin α. NLS (PKKKRKV) serves as a method to enhance nuclear entry in the field of gene transfer research .

NLS (PKKKRKV) (hydrochloride) 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) hydrochloride is the hydrochloride form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

TPh A 2 Publications Verification Triphenyl Compound A	Biochemical Assay Reagents	Cancer
TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a K_i of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells .

Transportan	Biochemical Assay Reagents	Cancer
Transportan is an amphipathic cell-penetrating peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine. Transportan interacts with galanin receptors and G-proteins, modulates GTPase activity, enters cells via direct translocation and endocytic pathways, accumulates in cytoplasmic, nuclear, and membranous structures, and delivers cargo including peptides, PNAs, proteins, siRNA, and liposomes ^[12].

Denosumab (anti-TNFSF11) 2 Publications Verification	RANKL/RANK Apoptosis NF-κB	Neurological Disease Endocrinology Cancer
Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the *receptor activator of nuclear* factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB** pathway. Denosumab can be used in bone-related studies .

Wright's stain	Fluorescent Dye	Others
Wright's stain is a composite cell stain that mainly binds to intracellular nucleic acids, proteins and other components through thiazine dyes (such as methylene blue) and eosin. Wright's stain is pH-dependent (optimal pH 6.4-6.7) and achieves cell morphology resolution by differentially staining the cytoplasm and nucleus. Under alkaline conditions, thiazine dyes bind to nucleic acids to form purple, and acidic eosin binds to cytoplasmic proteins to form red, which can form contrasting cell morphological features. Wright's stain can clearly display the fine structures of blood cells and bone marrow cells (such as nuclear chromatin and granules) and quickly evaluate cell morphological abnormalities .

MR837 1 Publications Verification	Histone Methyltransferase	Cancer
MR837 is an inhibitor of NSD2-PWWP1. MR837 can bind with human nuclear receptor binding SET domain protein 2 (PWWP domain) .

KB02-SLF	PROTACs FKBP	Cancer
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF .

Dezecapavir VH-499; VH4011499	HIV	Infection
Dezecapavir (VH-499) is a HIV-1 capsid protein inhibitor. Dezecapavir exhibits picomolar-level antiviral activity against a variety of HIV-1 laboratory strains and clinical isolates in vitro. Dezecapavir inhibits the early and late stages of the HIV-1 life cycle, blocking nuclear import, reverse transcript production, virion assembly, maturation, and post-nuclear import/pre-integration replication processes. Dezecapavir can be used in studies related to HIV-1 infection .

Difopein TFA	Apoptosis Bcl-2 Family Caspase	Cancer
Difopein TFA is a 14-3-3 protein inhibitor. Difopein TFA acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates Bcl-2, upregulates Bax, activates caspase-9 and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein TFA serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein TFA is applicable to glioma-related research .

SC912	Androgen Receptor Apoptosis	Cancer
SC912 is an AR-V7 inhibitor (IC₅₀ = 0.36 μM). SC912 possesses safety, potency and selectivity. SC912 binds directly to AR-FL and AR-V7 proteins, inhibites nuclear localization and chromatin binding capabilities. SC912 exerts anticancer activity through inhibition of proliferation, induction of cell cycle arrest and apoptosis .

Meloside A 4 Publications Verification Isovitexin 2''-O-glucoside; Isovitexin 2''-O-β-D-glucoside	Androgen Receptor Apoptosis Reactive Oxygen Species (ROS) Interleukin Related TGF-β Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Meloside A (Isovitexin 2''-O-glucoside) is a flavonoid with antioxidant activity. Meloside A can inhibit cell apoptosis and ROS production. Meloside A can inhibit androgen receptor (AR) nuclear translocation and AR protein expression. Meloside A can reduce IL-6, TGF-β1 and DKK-1 levels. Meloside A can be used for the researches of inflammation and endocrinology, such as hair loss .

INI-43 1 Publications Verification	AP-1 Apoptosis	Cancer
INI-43 is an inhibitor of Kpnβ1, interfering with the nuclear localization of Kpnβ1 and known Kpnβ1 cargo proteins, NFAT, NFκB, AP-1, and NFY. INI-43 can inhibit the proliferation of cancer cells, cause G₂-M cell cycle arrest in cancer cells, and induce the intrinsic apoptosis pathway .

UNC8153 TFA	Histone Methyltransferase	Cancer
UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a K_d of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein (DC₅₀ in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2 .

PRLX-93936 dihydrochloride	Molecular Glues Apoptosis Ras HIF/HIF Prolyl-Hydroxylase	Cancer
PRLX-93936 dihydrochloride is a molecular Glues that binds to and reprograms the TRIM21 ubiquitin ligase to degrade nuclear pore complexes. PRLX-93936 dihydrochloride binds to TRIM21, forms a ternary complex with TRIM21 and NUP98, and mediates the ubiquitination and proteasomal degradation of NUP98 and other nuclear pore complex proteins. PRLX-93936 dihydrochloride induces the loss of short-lived cytoplasmic mRNA transcripts, triggers cancer cell apoptosis (Apoptosis), and inhibits the activated Ras pathway. PRLX-93936 dihydrochloride inhibits HIF-1 under hypoxic conditions (IC₅₀ = 0.09 μM in cell-based reporter gene assay). PRLX-93936 dihydrochloride suppresses tumor growth in mouse models and improves survival rates in mouse models of multiple myeloma. PRLX-93936 dihydrochloride is applicable to research related to pancreatic cancer and multiple myeloma .

MS159 1 Publications Verification	PROTACs	Cancer
MS159 is a potent nuclear receptor binding SET structural domain protein 2 (NSD2) PROTACdegrader. MS159 inhibits the growth of tumour cells. MS159 is a useful chemical tool for exploring the role of NSD2 in health and disease .

G9a-IN-1	Histone Methyltransferase	Inflammation/Immunology Cancer
G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer .

BIMAX2 acetate	Ras	Others
BIMAX2 acetate is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 acetate can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 acetate can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .

Leptomycin A	CRM1 HIV Antibiotic	Infection
Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .

Biotinylated leptomycin B b-LMB	CRM1	Others
Biotinylated leptomycin B is a compound used to quantify nuclear export protein 1 (XPO1) occupancy and is used to study the interaction of SINE compounds with XPO1 and the response of cancer cells to related compounds.

Neomycin sulfate (Standard)	Reference Standards Bacterial Antibiotic Phospholipase	Infection Cancer
Neomycin (sulfate) (Standard) is the analytical standard of Neomycin (sulfate). This product is intended for research and analytical applications. Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis .

CB7993113	Aryl Hydrocarbon Receptor	Cancer
CB7993113 is a potent AHR antagonist, with an IC₅₀ of 0.33 μM. CB7993113 directly binds AHR protein and blocks AHR nuclear translocation. CB7993113 inhibits polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively .

MIND4-17	Keap1-Nrf2	Metabolic Disease
MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1. MIND4-17 disrupts Keap1-Nrf2 association, leading to Nrf2 protein stabilization and nuclear translocation. MIND4‐17 exerts potent antioxidant activity .

Alkyne-P60	Ligands for Target Protein for PROTAC	Cancer
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a *ligand for target protein* for PROTAC** (HY-162943).

UNC8153	Histone Methyltransferase	Cancer
UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a K_d of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC₅₀ in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2 .

biKEAP1	Keap1-Nrf2	Inflammation/Immunology
biKEAP1 (compound 3) is an inhibitor targeting the dimerKEAP1. biKEAP1 binds to cellular KEAP1 dimers and releases the NRF2 protein sequestered by KEAP1, resulting in immediate activation of NRF2. biKEAP1 also promotes nuclear translocation of NRF2 and directly inhibits proinflammatory cytokine transcription. biKEAP1 can reduce acute inflammation and reduce inflammatory damage in acute inflammation models .

Basivarsen linker	ADC Linker	Others
Basivarsen linker is a linker used in HY-177452 Zeleciment basivarsen for coupling a TfR1-binding Fab (HY-P990780 Zeleciment) and an antisense oligonucleotide. Zeleciment basivarsen is an antibody-oligonucleotide conjugate (AOC) designed to target mutant nuclear myotonic dystrophy protein kinase (DMPK) RNA for RHase H-mediated degradation to correct splicing. It is used for the study of myotonic dystrophy type 1 (DM1).

LT175	PPAR	Metabolic Disease Endocrinology
LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC₅₀=0.22 μm; mPPARα:EC₅₀=0.26 μm; hPPARγ:EC₅₀=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties .

Protein Kinase C (gamma) Peptide	PKC	Others
Protein Kinase C γ Peptide is a peptide fragment of Protein Kinase Cγ. Protein Kinase Cγ is a protein causative for dominant ataxia, that can negatively regulate nuclear import of recessive-ataxia-related aprataxin .

SAHA-BPyne	Fluorescent Dye	Others
SAHA-BPyne is an activity-based protein profiling (ABPP) probe for detecting HDAC activity, which covalently labels the proximal proteins through a photoactivation. SAHA-BPyne inhibits HDAC activity in HeLa nuclear lysate with an IC₅₀ of less than 5 μM .

Cat. No.	Product Name

HY-L126

Nuclear Receptor Compound Library

1,040 compounds

Nuclear receptors (NR) are proteins found in cells that sense androgen and thyroid hormones and certain other molecules. They are ligand-activated transcription factors that participate in many aspects of human physiology and pathology, and regulate the expression of various important genes.

Nuclear receptors have become one of the main targets in the development of new drug strategies, providing a unique type of receptors for studying a variety of human diseases, such as breast cancers, skin disorders and diabetes. 13% of U.S. Food and Drug Administration (FDA) approved drugs target nuclear receptors.

MCE supplies a unique collection of 1,040 nuclear receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on nuclear receptor. MCE Nuclear Receptor Library is a useful tool for drugs research related to cancer, skin disease and diabetes.

HY-L008

JAK/STAT Compound Library

704 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 704 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

HY-L014

NF-κB Signaling Compound Library

1,670 compounds

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB. These proteins function as dimeric transcription factors that regulate the expression of genes and influence a broad range of biological processes including innate and adaptive immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis. NF-κB plays a key role in regulating the immune response to infection. In addition, activation of the NF-κB pathway is involved in the pathogenesis of chronic inflammatory diseases, such as asthma, rheumatoid arthritis, and inflammatory bowel disease. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development.

MCE owns a unique collection of 1,670 small molecule compounds that can be used in the research of NF-κB signaling pathway or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Type

HY-W088068

Wright's stain

Fluorescent Dyes

Wright's stain is a composite cell stain that mainly binds to intracellular nucleic acids, proteins and other components through thiazine dyes (such as methylene blue) and eosin. Wright's stain is pH-dependent (optimal pH 6.4-6.7) and achieves cell morphology resolution by differentially staining the cytoplasm and nucleus. Under alkaline conditions, thiazine dyes bind to nucleic acids to form purple, and acidic eosin binds to cytoplasmic proteins to form red, which can form contrasting cell morphological features. Wright's stain can clearly display the fine structures of blood cells and bone marrow cells (such as nuclear chromatin and granules) and quickly evaluate cell morphological abnormalities .

HY-D0122

6-Iodoacetamidofluorescein	Fluorescent Dyes
6-Iodoacetamidofluorescein, a sulphhydryl-specific fluorescent dye, and can be used to selectively label the -SH groups of nuclear matrix polypeptides and proteins .

HY-138794G

XL177A

Fluorescent Dyes

XL177A GMP is XL177A (HY-138794) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. XL177A is a covalent USP7 inhibitor that blocks the deubiquitinase activity of USP7. XL177A destabilizes non-canonical PRC1 complexes or KDM6A and reduces chromatin deposition of H2AK119Ub, thereby relieving the repression of neuronal differentiation programs. Meanwhile, XL177A also regulates the ELOF1-UVSSA-USP7-nuclear β-catenin axis, decreasing the transcription levels of related proteins and the accumulation of nuclear β-catenin. XL177A exerts antiviral effects by reducing the expression levels of coronavirus receptors, and exhibits inhibitory activity against APC-mutated colorectal cancer cells, neuroblastoma, and coronaviruses including SARS-CoV-2 variants. XL177A is mainly used in studies related to colorectal cancer, neuroblastoma, and coronavirus infections .

Cat. No.	Product Name	Type

HY-125857C

Cytochrome C (bovine heart)	Biochemical Assay Reagents
Cytochrome C (bovine heart) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (bovine heart) acts as an effective ROS scavenger, but when combined with the cofactor p66Shc, it promotes the generation of ROS to initiate apoptosis. Cytochrome C (bovine heart) can act as a single electron carrier .

HY-125857A

Cytochrome C (equine heart)	Biochemical Assay Reagents
Cytochrome C (equine heart) is composed of 104 amino acids and is a nuclear-encoded mitochondrial protein. Cytochrome C (equine heart) is involved in mitochondrial electron transport and intrinsic type II apoptosis. Cytochrome C (equine heart) can act as a single electron carrier .

HY-W039939

2-Azido-2-deoxy-D-glucose, 98%

2-ADG, 98%

Biochemical Assay Reagents

2-Azido-2-deoxy-D-glucose, 98% (2-ADG, 98%) is a substrate of O-GlcNAc transferase (OGT). 2-Azido-2-deoxy-D-glucose, 98% can be transferred from UDP-GlcAz to proteins in vitro via OGT mediation. When delivered as AcGlcAz, 2-Azido-2-deoxy-D-glucose, 98% enables the labeling and investigation of O-GlcNAc-modified nuclear and cytoplasmic proteins in cells. 2-Azido-2-deoxy-D-glucose, 98% undergoes strain-promoted [3+2] azide-alkyne cycloaddition (SPAAC) with technetium- ^99m-labeled dibenzocyclooctyne derivatives in vivo. 2-Azido-2-deoxy-D-glucose, 98% can be used in sarcoma-related research .

HY-138794G

XL177A

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P4121

L17E	Potassium Channel	Inflammation/Immunology Cancer
L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .

HY-P1876

NLS (PKKKRKV) 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the SV40 large T antigen, which mediates the binding of karyophilic proteins to importin α. NLS (PKKKRKV) serves as a method to enhance nuclear entry in the field of gene transfer research .

HY-P1876B

NLS (PKKKRKV) (hydrochloride) 3 Publications Verification	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) hydrochloride is the hydrochloride form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

HY-P1732

Transportan	Biochemical Assay Reagents	Cancer
Transportan is an amphipathic cell-penetrating peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine. Transportan interacts with galanin receptors and G-proteins, modulates GTPase activity, enters cells via direct translocation and endocytic pathways, accumulates in cytoplasmic, nuclear, and membranous structures, and delivers cargo including peptides, PNAs, proteins, siRNA, and liposomes ^[12].

HY-P1380A

Difopein TFA	Apoptosis Bcl-2 Family Caspase	Cancer
Difopein TFA is a 14-3-3 protein inhibitor. Difopein TFA acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates Bcl-2, upregulates Bax, activates caspase-9 and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein TFA serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein TFA is applicable to glioma-related research .

HY-P10600A

BIMAX2 acetate	Ras	Others
BIMAX2 acetate is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 acetate can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 acetate can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .

HY-162946

Alkyne-P60	Ligands for Target Protein for PROTAC	Cancer
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a *ligand for target protein* for PROTAC** (HY-162943).

HY-P3838

Protein Kinase C (gamma) Peptide	PKC	Others
Protein Kinase C γ Peptide is a peptide fragment of Protein Kinase Cγ. Protein Kinase Cγ is a protein causative for dominant ataxia, that can negatively regulate nuclear import of recessive-ataxia-related aprataxin .

HY-P4101

Cys(Npys)-TAT (47-57)	HIV	Infection
Cys(Npys)-TAT (47-57) is a peptide fragment of TAT peptide and it is able to interact with plasmid DNA electrostatically. Cys(Npys)-TAT (47-57) is corresponding to the transduction domain of TAT with an activated cysteine residue C. TAT is a small nuclear transcriptional activator protein encoded by HIV-1 .

HY-P10600

BIMAX2	Ras	Others
BIMAX2 is a high affinity nuclear localization signal (NLS) peptide. BIMAX2 can mimic the activity of the classical nuclear localization signal (cNLS) and competitively bind to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. BIMAX2 can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence .

HY-P1876A

NLS (PKKKRKV) TFA	DNA/RNA Synthesis	Cancer
NLS (PKKKRKV) TFA is the TFA form of NLS (PKKKRKV) (HY-P1876). NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen), that mediates binding of the karyophilic protein to importin α. NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research .

HY-163315

YPLP	Keap1-Nrf2 AMPK	Metabolic Disease
YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active .

HY-P10421

PKCδ substrate	ERK	Cancer
PKCδ substrate acts as a nuclear transporter of ERK2 and is involved in ERK2 mediated gene activation. PKCδ is involved in the regulation of cell growth, proliferation, cell cycle arrest, and apoptosis by phosphorylating hBVR and other proteins. PKCδ substrate can be used to study the development of diseases, especially cancer biology .

HY-P1730

Nuclear pore complex protein Nup98 (315-360)	Peptides	Cancer
Nuclear pore complex protein Nup98 (315-360) is the 315-360 fragment part of the nuclear pore complex (NPC) protein .

HY-P5458

SRC-1 (686-700)	Mineralocorticoid Receptor	Others
SRC-1 (686-700) is a biological active peptide. (This peptide is amino acids 686 to 700 fragment containing the second LXXLL motif, derived from NR box II of steroid receptor coactivator (SRC1). Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.)

HY-P1920

CEF19, Epstein-Barr Virus latent NA-3A (458-466)	EBV	Inflammation/Immunology
CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain). CEF19, Epstein-Barr Virus latent NA-3A (458-466) can significantly affect cytotoxic T-lymphocyte (CTL) recognition .

HY-P11231

β4-TAT FUS(364-369)-TAT	Peptides	Cancer
β₄-TAT is a kind of β-sheet peptide foldamer. β₄-TAT is composed of two parts: the β4 sequence (derived from the β-sheet fragment of the RRM domain of fused in sarcoma (FUS)) and the TAT sequence (a nuclear localization signal peptide that helps the entire peptide penetrate the nuclear membrane). β₄-TAT influences FUS aggregation by targeting its RNA recognition motifs (RRM). β4-TAT effectively induces FUS aggregation within cells, leading to the death of cancer cells. β₄-TAT can be used for the study of FUS .

HY-P11662

NLS peptide	Peptides	Cancer
NLS peptide is a nuclear localization signal peptide, a short amino acid sequence that can be recognized by nuclear transport machinery (such as the Importin protein complex). NLS peptide can directionally transport the molecules or nanoparticles linked to it into the nucleus, and the N-terminal Cys terminus can be used for subsequent coupling. NLS peptide can be used to construct nucleus-specific imaging probes and nucleus-targeted nanoparticles

HY-P1380

Difopein	Apoptosis Bcl-2 Family Caspase	Cancer
Difopein is a 14-3-3 protein inhibitor. Difopein acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates Bcl-2, upregulates Bax, activates caspase-9 and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein is applicable to glioma-related research .

HY-P11137

LANA	HSV	Cancer
LANA is a KSHV latency-associated nuclear antigen. The core function of LANA is to act as an "anchor" for the viral genome, attaching it to the chromatin of the host cell. LANA ensures that the episomal DNA of KSHV replicates together with the host chromosome and is evenly distributed among the daughter cells, thereby maintaining the latent infection of the virus in the cell population. LANA can regulate the transcription of viral and host cell genes, and regulate certain host cell genes to promote cell survival. LANA can be used to study the viral DNA tethering structure .

HY-P11589

PIISVYWK	PPAR Reactive Oxygen Species (ROS) Keap1-Nrf2	Metabolic Disease
PIISVYWK is an orally active PPARγ Inhibitor, heme oxygenase-1 Activator, and Nrf2 Activator. PIISVYWK mediates activity via the HO-1/Nrf2 pathway, ameliorates oxidative stress, reduces inflammation, and mediates anti-obesity activity. PIISVYWK can be used for the research of obesity .

Cat. No.	Product Name

HY-K1003

Mammalian Active Protein Extraction Reagent 1 Publications Verification
MCE Mammalian Active Protein Extraction Reagent are gentle, non-denaturing detergents designed for the rapid, high-quality, and high-activity extraction of cytoplasmic, nuclear, and membrane proteins from mammalian cells or tissues. The 100 mL is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cat. No.	Product Name	Target	Research Area	Image

HY-P9958

Denosumab 2 Publications Verification AMG-162	NF-κB Caspase Apoptosis RANKL/RANK	Endocrinology Cancer
Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the *receptor activator of nuclear* factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB** pathway. Denosumab can be used in bone-related studies .

HY-P9958A

Denosumab (anti-TNFSF11) 2 Publications Verification	RANKL/RANK Apoptosis NF-κB	Neurological Disease Endocrinology Cancer
Denosumab (anti-TNFSF11) is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the *receptor activator of nuclear* factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (K_D of 0.003 nM for human RANKL). Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB** pathway. Denosumab can be used in bone-related studies .

Species:	Human (78) Rat (1) Mouse (4)
Tag:	SUMO (11) His (60) Tag Free (9) Avi (1) Myc (5) GST (16) B2M (1)
Source:	HEK293 (9) P. pastoris (3) Sf9 insect cells (16) E. coli (55)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75947

	NUDC Protein, Human (HEK293, His) nuclear migration protein nudC; nuclear distribution protein C homolog; NUDC	Human	HEK293
	NUDC protein is essential for neurogenesis and neuronal migration, contributing to the correct formation of mitotic spindles and chromosome separation during mitosis. It plays a crucial role in cytokinesis and cell proliferation. NUDC interacts with PAFAH1B1, forms a complex with PLK1, dynein, and dynactin, and interacts with DCDC1 and EML4, emphasizing its multifaceted involvement in various cellular processes. NUDC Protein, Human (HEK293, His) is the recombinant human-derived NUDC protein, expressed by HEK293 , with C-His labeled tag.

HY-P72229

	HNRNPA1 Protein, Human (His) 1 Publications Verification HNRNPA 1; Helix destabilizing protein; Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; Heterogeneous nuclear ribonucleoprotein A1B protein; Heterogeneous nuclear ribonucleoprotein B2 protein; Heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP core protein A1; HNRNPA1; HNRPA1;	Human	E. coli
	The HNRNPA1 protein is complexly involved in multiple RNA processing functions, packaging pre-mRNA into hnRNP particles, promoting Poly(A) mRNA transport, and regulating splice site selection. Crucially, it binds inhibitoryly to sequences flanking PKM exon 9, favoring the inclusion of exon 10 in pyruvate kinase PKM splicing, thereby generating the PKM M2 isoform. HNRNPA1 Protein, Human (His) is the recombinant human-derived HNRNPA1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P77093

	MUSTN1 Protein, Human (His) Musculoskeletal embryonic nuclear protein 1; MUSTN1	Human	E. coli
	The MUSTN1 protein emerged as a potential regulator of musculoskeletal development and regeneration, coordinating key molecular events. Its specificity highlights its role in the complex signaling pathways that control musculoskeletal tissue. MUSTN1 Protein, Human (His) is the recombinant human-derived MUSTN1 protein, expressed by E. coli , with N-His labeled tag.

HY-P71135

	NFYA Protein, Human nuclear Transcription Factor Y Subunit Alpha; CAAT Box DNA-Binding protein Subunit A; nuclear Transcription Factor Y Subunit A; NF-YA; NFYA	Human	E. coli
	The NFYA protein is a component of the NF-Y transcription factor and recognizes the 5'-CCAAT-3' box motif in gene promoters. NFYA functions as an activator or repressor depending on the interacting cofactors. NFYA Protein, Human is the recombinant human-derived NFYA protein, expressed by E. coli , with tag free.

HY-P7840A

	CLIC1 Protein, Human (N-His) Chloride Intracellular Channel protein 1; Chloride Channel ABP; nuclear Chloride Ion Channel 27; NCC27; Regulatory nuclear Chloride Ion Channel protein; hRNCC; CLIC1; G6; NCC27	Human	E. coli
	The CLIC1 protein exhibits specific lysophospholipase activity and plays a critical role in mediating cellular responses to oxidative stress. As a member of the chloride intracellular channel family, CLIC1 is involved in a variety of physiological processes, including cell volume regulation, membrane potential regulation, and regulation of cell cycle progression. CLIC1 Protein, Human (N-His) is the recombinant human-derived CLIC1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P73729

	PCNA Protein, Human (sf9, His) 1 Publications Verification Proliferating cell nuclear antigen; PCNA; Cyclin	Human	Sf9 insect cells
	PCNA, an atypical member of the sulfotransferase family, displays notably low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and minimal catalytic activity towards substrates like L-triiodothyronine, thyroxine, estrone, p-nitrophenol, 2-naphthylamine, and 2-beta-naphthol. Its precise function remains elusive, but PCNA is suggested to participate in drug and neurotransmitter metabolism within the central nervous system (CNS). PCNA Protein, Human (sf9, His) is the recombinant human-derived PCNA protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P701396

	PXR Protein, Human NR1I2; nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR	Human	E. coli
	The PXR protein is a nuclear receptor that acts as a multifunctional transcription factor activated by a variety of endogenous and exogenous compounds. It regulates genes involved in the metabolism and secretion of substances, responding to ligands such as rifampicin, hypericin, gugulin, colupulone, isoflavones, pregnenolone and progesterone. PXR Protein, Human is the recombinant human-derived PXR protein, expressed by E. coli , with tag free.

HY-P701400

	RORa Protein, Human (sf9) RORA; nuclear receptor ROR-alpha; nuclear receptor RZR-alpha; nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha	Human	Sf9 insect cells
	The RORa protein is a nuclear receptor that is critical for a variety of physiological processes including development, immunity, circadian rhythms, and metabolic pathways. RORa operates as a monomer, binding DNA to RORE and exhibiting intrinsic transcriptional activity. RORa Protein, Human (sf9) is the recombinant human-derived RORa protein, expressed by sf9 insect cells , with tag free.

HY-P72233

	HNRNPH1 Protein, Human (His-SUMO) DKFZp686A15170; Heterogeneous nuclear ribonucleoprotein H; Heterogeneous nuclear ribonucleoprotein H1 H; ; Heterogeneous nuclear ribonucleoprotein H1; HNRH1_HUMAN; hnRNP H; hnRNPH; Hnrnph1; HNRPH 1; HNRPH; HNRPH1 protein; N-terminally processed	Human	E. coli
	The HNRNPH1 protein is an important component of the hnRNP complex and plays a key role in pre-mRNA processing events leading to mRNA conversion in the cytoplasm. Functionally, it cooperates with CUGBP1 to regulate alternative splicing of pre-mRNA, specifically inhibiting the inclusion of insulin receptor (IR) pre-mRNA exon 11 in myoblasts. HNRNPH1 Protein, Human (His-SUMO) is the recombinant human-derived HNRNPH1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P701397

	PXR Protein, Human (His) NR1I2; nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR	Human	E. coli
	The PXR protein is a nuclear receptor that acts as a multifunctional transcription factor activated by a variety of endogenous and exogenous compounds. It regulates genes involved in the metabolism and secretion of substances, responding to ligands such as rifampicin, hypericin, gugulin, colupulone, isoflavones, pregnenolone and progesterone. PXR Protein, Human (His) is the recombinant human-derived PXR protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701401

	RORa Protein, Human (sf9, His) RORA; nuclear receptor ROR-alpha; nuclear receptor RZR-alpha; nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; Retinoid-related orphan receptor-alpha	Human	Sf9 insect cells
	The RORa protein is a nuclear receptor that is critical for a variety of physiological processes including development, immunity, circadian rhythms, and metabolic pathways. RORa operates as a monomer, binding DNA to RORE and exhibiting intrinsic transcriptional activity. RORa Protein, Human (sf9, His) is the recombinant human-derived RORa protein, expressed by sf9 insect cells , with N-8*His labeled tag.

HY-P702911

	NSD3 Protein, Human (GST) WHSC1L1; DC28; nuclear SET domain-containing protein 3	Human	E. coli
	NSD3 Protein, Human (GST) is the recombinant human-derived NSD3, expressed by E. coli , with N-GST labeled tag. ,

HY-P73700

	PRAC Protein, Human (His-SUMO) Small nuclear protein PRAC1; PRAC1; C17orf92; PRAC	Human	E. coli
	PRAC Protein exhibits high expression in the prostate, rectum, and distal colon, with weaker expression in the bladder. Its prominence in prostate cancer cell lines suggests a potential link to prostate cancer pathology. The tissue-specific expression emphasizes PRAC Protein's potential roles in normal physiological processes and cancer contexts. PRAC Protein, Human (His-SUMO) is the recombinant human-derived PRAC protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

HY-P73920

	HNRNPR Protein, Human (sf9, His-GST) Heterogeneous nuclear ribonucleoprotein R; hnRNP R; HNRNPR	Human	Sf9 insect cells
	hnRNP-R Protein, a constituent of ribonucleosomes, participates in precursor mRNA processing within the nucleus. It's part of the spliceosome C complex and involved in IGF2BP1-dependent mRNP granule complexes containing untranslated mRNAs. Additionally, hnRNP-R interacts with GTPBP1. HNRNPR Protein, Human (sf9, His-GST) is the recombinant human-derived hnRNP-R protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P74377

	C1D Protein, Human (His) nuclear nucleic acid-binding protein C1D; hC1D; C1D	Human	E. coli
	The C1D protein has multifunctionality in cellular processes, recruiting RNA exosome complexes for 5.8S rRNA processing, possibly in conjunction with MPHOSPH6. It activates PRKDC with linear and supercoiled DNA and induces apoptosis through the p53/TP53 pathway. C1D Protein, Human (His) is the recombinant human-derived C1D protein, expressed by E. coli , with N-6*His labeled tag.

HY-P701154

	*U1A/SNRPA Protein, Human (HEK293, C-6His)** U1 small nuclear ribonucleoprotein A	Human	HEK293
	U1A/SNRPA Protein, Human (HEK293, C-6His) is the recombinant human-derived U1A/SNRPA, expressed by HEK293* , with C-6*His labeled tag. ,

HY-P71191

	PDCD4 Protein, Human (His) Programmed Cell Death protein 4; Neoplastic Transformation Inhibitor protein; nuclear Antigen H731-Like; protein 197/15a; PDCD4; H731	Human	E. coli
	PDCD4 inhibits translation initiation by disrupting the EIF4A1-EIF4G interaction and inhibiting EIF4A helicase activity. It regulates JUN kinase activation and downregulates MAP4K1, inhibiting invasion and tumorigenesis. PDCD4 Protein, Human (His) is the recombinant human-derived PDCD4 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P71545

	MORC3 Protein, Human (His-SUMO) KIAA0136; Microrchidia 3; MORC family CW type zinc finger 3; MORC family CW type zinc finger protein 3; MORC family CW-type zinc finger protein 3; MORC3; MORC3_HUMAN; nuclear matrix protein 2; nuclear matrix protein NXP2; NXP2; ZCW5; ZCWCC3	Human	E. coli
	MORC3 protein is a nuclear matrix protein that forms MORC3-NB through an ATP-dependent mechanism to restrict viruses through IFN response regulation, which is critical for innate immunity.It regulates IFNB1 activation and has secondary IFN inhibitory functions.MORC3 Protein, Human (His-SUMO) is the recombinant human-derived MORC3 protein, expressed by E.coli , with N-His, N-SUMO labeled tag.

HY-P702591

	PTBP1 Protein, Human (HEK293, His) Polypyrimidine tract-binding protein 1; PTB; 57 kDa RNA-binding protein PPTB-1; Heterogeneous nuclear ribonucleoprotein I (hnRNP I)	Human	HEK293
	PTBP1 Protein, Human (HEK293, His) is the recombinant human-derived PTBP1, expressed by HEK293 , with N-10*His labeled tag. ,

HY-P705576

	FRK Protein, Human (Active, sf9, GST) Tyrosine-protein kinase FRK; FYN-related kinase; nuclear tyrosine protein kinase RAK; protein-tyrosine kinase 5; PTK5, RAK	Human	Sf9 insect cells

HY-P701693

	HIPK1 Protein, Human (Active, sf9) HIPK1; Homeodomain-interacting protein kinase 1; nuclear body-associated kinase 2	Human	Sf9 insect cells
	HIPK1 is a multifunctional serine/threonine protein kinase that complexly regulates transcriptional control and TNF-mediated apoptosis. It acts as a corepressor for homeodomain transcription factors and regulates gene expression by phosphorylating the substrates DAXX and MYB. HIPK1 Protein, Human (sf9) is the recombinant human-derived HIPK1 protein, expressed by sf9 insect cells , with tag free.

HY-P72234

	HNRNPM Protein, Human (His-SUMO) CEA receptor; CEAR; Heterogeneous nuclear ribonucleoprotein M; Heterogenous nuclear ribonucleoprotein M4; hnRNA binding protein M4; hnRNP M; Hnrnpm; HNRNPM4; HNRPM; HNRPM_HUMAN; HNRPM4; HTGR1; M3; M4; M4 protein; N-acetylglucosamine receptor 1; NAGR1	Human	E. coli
	The HNRNPM protein is a key pre-mRNA binding protein that exhibits strong affinity for poly(G) and poly(U) RNA homopolymers. It is central to the splicing process, complexly regulates RNA maturation, and serves as a receptor for carcinoembryonic antigen in Kupffer cells. HNRNPM Protein, Human (His-SUMO) is the recombinant human-derived HNRNPM protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P701252

	RPRD1B Protein, Human (HEK293, N-His) Regulation of nuclear pre-mRNA domain-containing protein 1B; C20orf77; CREPT	Human	HEK293
	RPRD1B, is a necessary scaffolding protein that maintains genetic integrity by regulating resolution of R-loops at both the transcription termination and DNA double-strand break (DSB) repair levels. In endometrial cancers, RPRD1B accelerates cell cycle through up-regulating Cyclin D1, CDK4, and CDK6. In addition, RPRD1B enhancse transcription of CCND1 and promotes cell proliferation by interacting with RNA polymerase II. RPRD1B enhances the β-Catenin·TCF4 transcriptional activity in response to Wnt signaling. RPRD1B Protein, Human (HEK293, N-His) is the recombinant human-derived RPRD1B protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P71765

	NR4A2 Protein, Human (P.pastoris, His) HZF 3; HZF3; Immediate-early response protein NOT; Transcriptionally-inducible nuclear receptor	Human	P. pastoris
	NR4A2, a crucial transcriptional regulator, is vital for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons. It plays a pivotal role in the expression of key genes (SLC6A3, SLC18A2, TH, DRD2) essential for mdDA neuron development. Interactions with SFPQ, NCOR2, SIN3A, HADC1, and PER2 contribute to its regulatory functions in mdDA neuron development, with the NCOR2 interaction influenced by the absence of PITX3. NR4A2 Protein, Human (P.pastoris, His) is the recombinant human-derived NR4A2 protein, expressed by P. pastoris , with N-His labeled tag.

HY-P701694

	HIPK1 Protein, Human (Active, sf9, GST) HIPK1; Homeodomain-interacting protein kinase 1; nuclear body-associated kinase 2	Human	Sf9 insect cells
	HIPK1 is a multifunctional serine/threonine protein kinase that complexly regulates transcriptional control and TNF-mediated apoptosis. It acts as a corepressor for homeodomain transcription factors and regulates gene expression by phosphorylating the substrates DAXX and MYB. HIPK1 Protein, Human (sf9, GST) is the recombinant human-derived HIPK1 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P72263

	NUP210 Protein, Human (His) Nucleoporin 210; POM 210; nuclear pore membrane glycoprotein 210	Human	E. coli
	NUP210 Protein, a nucleoporin, crucially contributes to nuclear pore assembly, spacing, and structural integrity, ensuring proper nuclear pore function for molecular transport between the nucleus and cytoplasm.NUP210 forms dimers and potentially higher-order oligomers, highlighting its intricate role in nuclear pore architecture.NUP210 Protein, Human (His) is the recombinant human-derived NUP210 protein, expressed by E.coli , with N-6*His labeled tag.

HY-P701516

	UHRF2 Protein, Human (His, SUMO) UHRF2; E3 ubiquitin-protein ligase UHRF2; Np95/ICBP90-like RING finger protein; Np95-like RING finger protein; nuclear protein 97; nuclear zinc finger protein Np97; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF2; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2	Human	E. coli
	UHRF2 protein is an E3 ubiquitin ligase involved in DNA methylation, histone modification, cell cycle regulation and DNA repair. UHRF2 Protein, Human (His, SUMO) is the recombinant human-derived UHRF2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P705633

	UHRF2 Protein, Human UHRF2; E3 ubiquitin-protein ligase UHRF2; Np95/ICBP90-like RING finger protein; Np95-like RING finger protein; nuclear protein 97; nuclear zinc finger protein Np97; RING finger protein 107; RING-type E3 ubiquitin transferase UHRF2; Ubiquitin-like PHD and RING finger domain-containing protein 2; Ubiquitin-like-containing PHD and RING finger domains protein 2	Human	E. coli
	UHRF2 protein is an E3 ubiquitin ligase involved in DNA methylation, histone modification, cell cycle regulation and DNA repair. UHRF2 Protein, Human is the recombinant human-derived UHRF2 protein, expressed by E. coli.

HY-P7S0152

	RORC Protein, Human (His, SUMO) nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; RORC; NR1F3; RORG; RZRG	Human	E. coli
	RORC Protein, Human (His, SUMO) is the recombinant human-derived RORC, expressed by E. coli , with N-6*His, N-SUMO labeled tag. ,

HY-P704045

	RORC Protein, Mouse (P. pastoris, His) nuclear receptor RZR-gamma; nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; RORC; NR1F3; RORG; RZRG	Mouse	P. pastoris
	RORC Protein, Mouse (P. pastoris, His) is the recombinant human-derived RORC, expressed by P. pastoris , with N-6*His labeled tag.

HY-P72134

	CEBP delta/CEBPD Protein, Human (His-Myc) C/EBP delta; C/EBP related protein 3; CCAAT/enhancer binding protein C/EBP; delta; CCAAT/enhancer binding protein delta; CCAAT/enhancer-binding protein delta; CEBP D; CEBPD; CEBPD_HUMAN; CELF; Crp 3; Crp3; NF IL6 beta; NF-IL6-beta; nuclear factor NF IL6 beta; nuclear factor NF-IL6-beta	Human	E. coli
	The CEBP delta/CEBPD protein is a transcriptional activator that recognizes CCAAT and enhanced core motifs. It is critical for immune and inflammatory response genes and enhances IL6 transcription independently or together with CEBPB. CEBP delta/CEBPD Protein, Human (His-Myc) is the recombinant human-derived CEBP delta/CEBPD protein, expressed by E. coli , with N-10*His, C-Myc labeled tag.

HY-P705107

	NUP85 Protein, Human (His, Myc) nuclear pore complex protein Nup85; NUP85; 85 kDa nucleoporin; FROUNT; Nucleoporin Nup75; Nucleoporin Nup85; Pericentrin-1	Human	E. coli

HY-P76523

	NRBF2 Protein, Human (sf9, His-GST) nuclear receptor-binding factor 2; Comodulator of PPAR and RXR; COPR	Human	Sf9 insect cells
	NRBF2 protein may regulate transcriptional activation through target nuclear receptors and act as a transcriptional activator in vitro. It participates in starvation-induced autophagy, binding to PI3K complex I (PI3KC3-C1) and stabilizing its assembly. NRBF2 Protein, Human (sf9, His-GST) is the recombinant human-derived NRBF2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P702781

	NR3C1 Protein, Human (His) GCCR; GCR; GCR_HUMAN; GCRST; glucocorticoid nuclear receptor variant 1; Glucocorticoid receptor; GR; GRL; Grl1; nr3c1; nuclear receptor subfamily 3 group C member 1	Human	E. coli
	NR3C1 Protein, Human (His, GST) is the recombinant human-derived NR3C1, expressed by E. coli , with N-10*His, N-GST labeled tag. ,

HY-P7S0363

	PPARD Protein, Human (HEK293, His) Peroxisome proliferator-activated receptor delta; PPAR-delta; NUCI; nuclear hormone receptor 1 (NUC1); nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta (PPAR-beta);	Human	HEK293
	PPARD protein is a ligand-activated transcription factor that critically mediates energy metabolism in adipose tissue. As a receptor, it selectively binds peroxisome proliferators, including hypolipidemic drugs and fatty acids, and preferentially binds polyunsaturated substances. PPARD Protein, Human (HEK293, His) is the recombinant human-derived PPARD protein, expressed by HEK293, with C-6*His labeled tag.

HY-P706059

	IKBKB Protein, Human (Active, sf9, His-GST) Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B kinase 2; IKK-2; IKK2; nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB; 2.7.11.1; IKKB	Human	Sf9 insect cells

HY-P702078

	RNF4 Protein, Human (Active, 71a.a) RNF4; E3 ubiquitin-protein ligase RNF4; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; protein SNURF	Human	E. coli
	RNF4 protein is an E3 ubiquitin protein ligase that can uniquely bind and ubiquitinate polyubiquitination chains, mediating "Lys-6", "Lys-11", "Lys-48" and "Lys- 63"-linked polyubiquitination to promote proteasomal degradation. Its multiple substrates, including PML and PEA3, regulate various cellular processes. RNF4 Protein, Human (Active, 71a.a) is the recombinant human-derived RNF4 protein, expressed by E. coli , with tag free.

HY-P77109

	NUP210 Protein, Human (sf9, GST) Nucleoporin 210; POM 210; nuclear pore membrane glycoprotein 210	Human	Sf9 insect cells
	NUP210 Protein, a nucleoporin, crucially contributes to nuclear pore assembly, spacing, and structural integrity, ensuring proper nuclear pore function for molecular transport between the nucleus and cytoplasm. NUP210 forms dimers and potentially higher-order oligomers, highlighting its intricate role in nuclear pore architecture. NUP210 Protein, Human (sf9, GST) is the recombinant human-derived NUP210 protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P700454

	IGFLR1 Protein, Human (HEK293, C-His) IGFLR1; IGF-like family receptor 1; TMEM149, transmembrane protein 149 , U2(RNU2) small nuclear RNA auxiliary factor 1 like 4 , U2AF1L4; FLJ22573; transmembrane protein 149; U2 small nuclear RNA auxiliary factor 1-like 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like 4; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, C-His) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P701786

	IKKβ Protein, Human (sf9, GST) 1 Publications Verification IKBKβ; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB	Human	Sf9 insect cells
	IKKβ protein is a serine kinase that is critical in the NF-kappa-B signaling pathway and can respond to various stimuli such as cytokines or cellular stress. As part of the classical IKK complex, IKKβ activates NF-kappa-B through phosphorylation inhibitors, leading to its degradation and release of NF-kappa-B for gene transcription. IKKβ Protein, Human (sf9, GST) is the recombinant human-derived IKKβ protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P702079

	RNF4 Protein, Human (Active, 71a.a, GST) RNF4; E3 ubiquitin-protein ligase RNF4; RING finger protein 4; RING-type E3 ubiquitin transferase RNF4; Small nuclear ring finger protein; protein SNURF	Human	E. coli
	RNF4 protein is an E3 ubiquitin protein ligase that can uniquely bind and ubiquitinate polyubiquitination chains, mediating "Lys-6", "Lys-11", "Lys-48" and "Lys- 63"-linked polyubiquitination to promote proteasomal degradation. Its multiple substrates, including PML and PEA3, regulate various cellular processes. RNF4 Protein, Human (Active, 71a.a, GST) is the recombinant human-derived RNF4 protein, expressed by E. coli , with N-GST labeled tag.

HY-P701698

	HIPK3 Protein, Human (Active, sf9, GST) HIPK3; Homeodomain-interacting protein kinase 3; Androgen receptor-interacting nuclear protein kinase; ANPK; Fas-interacting serine/threonine-protein kinase; FIST; Homolog of protein kinase YAK1	Human	Sf9 insect cells
	HIPK3 is a multifaceted serine/threonine protein kinase that plays multiple roles in transcriptional regulation, apoptosis, and steroidogenic gene expression. It phosphorylates the transcription factors JUN and RUNX2, contributing to complex gene expression control. HIPK3 Protein, Human (sf9, GST) is the recombinant human-derived HIPK3 protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P701336

	PPAR gamma Protein, Human PPARG; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3	Human	E. coli
	The PPAR gamma protein is a nuclear receptor that binds to peroxisome proliferators and is activated upon ligand binding to specific PPREs on DNA. It regulates target gene transcription and controls fatty acid metabolism. PPAR gamma Protein, Human is the recombinant human-derived PPAR gamma protein, expressed by E. coli , with tag free.

HY-P701402

	RXRB Protein, Human RXRB; Retinoic acid receptor RXR-beta; nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta	Human	E. coli
	RXRB protein is a receptor for retinoic acid and forms a heterodimer, especially RAR/RXR, which regulates gene expression through the retinoic acid response element (RARE). RXRB exhibits homodimerization and forms heterodimers with other retinoic acid receptor family members. RXRB Protein, Human is the recombinant human-derived RXRB protein, expressed by E. coli , with tag free.

HY-P70198

	LSM1 Protein, Human (His) rHuU6 snRNA-associated Sm-like protein LSm1, His; U6 snRNA-Associated Sm-Like protein LSm1; Cancer-Associated Sm-Like; Small nuclear Ribonuclear CaSm; LSM1; CASM	Human	E. coli
	LSM1 protein participates in the degradation of histone mRNAs, unique among eukaryotic mRNAs for lacking polyadenylation.Likely part of an LSm subunit-containing complex involved in general mRNA degradation.It interacts with SLBP, particularly during rapid histone mRNA degradation in the S phase.The LSm subunits collectively form a donut-shaped heteromer.LSM1 Protein, Human (His) is the recombinant human-derived LSM1 protein, expressed by E.coli , with C-6*His labeled tag.

HY-P71649

	GSDMC Protein, Human (His-SUMO) Gasdermin C; Gasdermin-C; GSDMC; Melanoma derived leucine zipper, extra nuclear factor; Melanoma-derived leucine zipper-containing extranuclear factor; MLZE	Human	E. coli
	GSDMC protein serves as the precursor of pore-forming proteins and undergoes cleavage to release Gasdermin-C. This N-terminal moiety binds to the membrane, forming pores with an inner diameter of 10 to 15 nm and inducing pyroptosis. GSDMC Protein, Human (His-SUMO) is the recombinant human-derived GSDMC protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

HY-P701403

	RXRB Protein, Human (His) RXRB; Retinoic acid receptor RXR-beta; nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta	Human	E. coli
	RXRB protein is a receptor for retinoic acid and forms a heterodimer, especially RAR/RXR, which regulates gene expression through the retinoic acid response element (RARE). RXRB exhibits homodimerization and forms heterodimers with other retinoic acid receptor family members. RXRB Protein, Human (His) is the recombinant human-derived RXRB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705924

	NR2F6 Protein, Human (His) nuclear receptor subfamily 2 group F member 6; V-erbA-related protein 2 (EAR-2); NR2F6; EAR2; ERBAL2	Human	E. coli

HY-P701118

	NIP30 Protein, Human (HEK293, His) FAM192A; CDA10; NIP30; CDA018; C16orf94; family with sequence similarity 192, member A; protein FAM192A; NEFA-interacting nuclear protein NIP30	Human	HEK293
	The NIP30 protein negatively regulates proteasomal protein catabolism and protein binding activity. It is located in the nucleus and is expressed in various tissues including the brain and testis. NIP30 Protein, Human (HEK293, His) is the recombinant human-derived NIP30 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70140

	MECR Protein, Human (HEK293, His) rHuEnoyl-[acyl-carrier-protein] reductase, mitochondrial/MECR, His; Trans-2-Enoyl-CoA Reductase Mitochondrial; nuclear Receptor-Binding Factor 1; HsNrbf-1NRBF-1; MECR; NBRF1	Human	HEK293
	MECR Protein, Human (HEK293, His) is the recombinant human-derived MECR protein, expressed by HEK293, with C-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (35) Rabbit (89)
Reactivity:	Human (123) rat (1) Bovine (2) Rat (71) Mouse (81) Monkey (7) Zebrafish (1) Chicken (2) Dog (2) Hamster (6) Pig (2)
Application:	WB FC ICC/IF (2) IHC-P (77) ICC/IF (75) IF-Tissue (10) IP (36) IHC-F (12) WB (110) FC (21) Dot Blot (1) ELISA (20)
Isotype:	IgG (86) IgG1 (15) IgG/Kappa (3)
Conjugation:	Non-conjugated (124) Biotin (1)
Clonality:	Polyclonal (1) Monoclonal (94) Recombinant (50)
Modification:	Phosphorylated (4) Unmodified (91)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81449

	hnRNP K Antibody (YA1194) HNRNPK; HNRPK; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP	IHC-P	Human
	hnRNP K Antibody (YA1194) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to hnRNP K.

HY-P83062

	CLIC1 Antibody (YA2807) Chloride intracellular channel protein 1; Chloride channel ABP; nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC	WB, ICC/IF, FC, IP	Human, Mouse, Rat
	CLIC1 Antibody (YA2807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIC1.

HY-P83062A

	CLIC1 Antibody (YA2807)(PBS only) Chloride intracellular channel protein 1; Chloride channel ABP; nuclear chloride ion channel 27; NCC27; Regulatory nuclear chloride ion channel protein; hRNCC	WB, ICC/IF, FC, IP	Human, Mouse, Rat
	CLIC1 Antibody (YA2807) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLIC1.

HY-P81449A

	hnRNP K Antibody (YA1194)(PBS only) HNRNPK; HNRPK; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP	IHC-P	Human
	hnRNP K Antibody (YA1194) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to hnRNP K.

HY-P82076

	Ran Antibody (YA1821) RAN; ARA24; OK/SW-cl.81; GTP-binding nuclear protein Ran; Androgen receptor-associated protein 24; GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein	WB, ICC/IF, IP	Human, Mouse, Monkey
	Ran Antibody (YA1821) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ran.

HY-P82076A

	Ran Antibody (YA1821)(PBS only) RAN; ARA24; OK/SW-cl.81; GTP-binding nuclear protein Ran; Androgen receptor-associated protein 24; GTPase Ran; Ras-like protein TC4; Ras-related nuclear protein	WB, ICC/IF, IP	Human, Mouse, Monkey
	Ran Antibody (YA1821) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Ran.

HY-P81651

	NFYA Antibody (YA1396) NFYA; nuclear transcription factor Y subunit alpha; CAAT box DNA-binding protein subunit A; nuclear transcription factor Y subunit A; NF-YA	WB, IP	Human, Mouse, Rat
	NFYA Antibody (YA1396) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NFYA.

HY-P85444

	NFIC Antibody (YA5136) NFIC; NFI; nuclear factor 1 C-type; NF1-C; nuclear factor 1/C; CCAAT-box-binding transcription factor; CTF; nuclear factor I/C; NF-I/C; NFI-C; TGGCA-binding protein	WB	Human, Mouse, Rat, Bovine, Chicken, Pig
	NFIC Antibody (YA5136) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NFIC.

HY-P81279

	hnRNP U Antibody (YA979) Heterogeneous nuclear ribonucleoprotein U; hnRNP U protein; HNRNPU; hnRNPU protein; HNRPU; HNRPU_HUMAN; p120; p120 nuclear protein; SAF A; SAF-A; SAFA; Scaffold attachment factor A; U21.1.	WB	Human
	hnRNP U Antibody (YA979) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to hnRNP U.

HY-P81279A

	hnRNP U Antibody (YA980) Heterogeneous nuclear ribonucleoprotein U; hnRNP U protein; HNRNPU; hnRNPU protein; HNRPU; HNRPU_HUMAN; p120; p120 nuclear protein; SAF A; SAF-A; SAFA; Scaffold attachment factor A; U21.1.	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	hnRNP U Antibody (YA980) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to hnRNP U.

HY-P85543

	hnRNP U Antibody (YA5235) Heterogeneous nuclear ribonucleoprotein U; hnRNP U protein; HNRNPU; hnRNPU protein; HNRPU; HNRPU_HUMAN; p120; p120 nuclear protein; SAF A; SAF-A; SAFA; Scaffold attachment factor A; U21.1.	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	hnRNP U Antibody (YA5235) is a Rabbit-derived and non-conjugated recombinant monoclonal antibody, targeting to hnRNP U.

HY-P85036

	ANP32A Antibody ANP32A; C15orf1; LANP; MAPM; PHAP1; Acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic nuclear phosphoprotein pp32; Leucine-rich acidic nuclear protein; LANP; Mapmodulin; Potent heat-stable protein phosphatase 2A inhibito	WB, IHC-P	Human
	ANP32A Antibody is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to ANP32A.

HY-P86981

	NDP52 Antibody (YA6674) Antigen nuclear dot 52 kDa protein antibody; CACO2_HUMAN antibody; Calcium binding and coiled coil domain 2 antibody; Calcium binding and coiled coil domain containing protein 2 antibody; Calcium-binding and coiled-coil domain-containing protein 2 antibody; CALCOCO 2 antibody; CALCOCO2 antibody; MGC17318 antibody; NDP52 antibody; nuclear domain 10 protein 52 antibody; Antigen nuclear dot 52 kDa protein antibody; CACO2_HUMAN antibody; Calcium binding and coiled coil domain 2 antibody; Calcium binding and coiled coil domain containing protein 2 antibody; Calcium-binding and coiled-coil domain-containing protein 2 antibody; CALCOCO 2 antibody; CALCOCO2 antibody; MGC17318 antibody; NDP52 antibody; nuclear domain 10 protein 52 antibody; nuclear domain 10 protein antibody; nuclear domain 10 protein NDP52 antibody; nuclear domain protein 52 antibody; nuclear dot protein 52 antibody; OTTHUMP00000218344 antibody; OTTHUMP00000218345 antibody; OTTHUMP00000218346 antibody; OTTHUMP00000218347 antibody; OTTHUMP00000218349 antibody; OTTHUMP00000218351 antibody;	WB, FC	Human, Mouse
	NDP52 Antibody (YA6674) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NDP52.

HY-P81692

	Nuclear Matrix Protein p84 Antibody (YA1437) Death domain containing protein p84N5; HPR1; hTREX84; nuclear matrix protein p84; p84N5; THO complex 1; Tho1; Thoc1	WB, ICC/IF	Human
	Nuclear Matrix Protein p84 Antibody (YA1437) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nuclear Matrix Protein p84.

HY-P81651A

	NFYA Antibody (YA1396)(PBS only) NFYA; nuclear transcription factor Y subunit alpha; CAAT box DNA-binding protein subunit A; nuclear transcription factor Y subunit A; NF-YA	WB, IP	Human, Mouse, Rat
	NFYA Antibody (YA1396) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NFYA.

HY-P81717

	NUR77 Antibody (YA1462) NR4A1; GFRP1; HMR; NAK1; nuclear receptor subfamily 4 group A member 1; Early response protein NAK1; nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3	WB	Human, Mouse, Rat
	NUR77 Antibody (YA1462) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NUR77.

HY-P81692A

	Nuclear Matrix Protein p84 Antibody (YA1437)(PBS only) Death domain containing protein p84N5; HPR1; hTREX84; nuclear matrix protein p84; p84N5; THO complex 1; Tho1; Thoc1	WB, ICC/IF	Human
	Nuclear Matrix Protein p84 Antibody (YA1437) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nuclear Matrix Protein p84.

HY-P81717A

	NUR77 Antibody (YA1462)(PBS only) NR4A1; GFRP1; HMR; NAK1; nuclear receptor subfamily 4 group A member 1; Early response protein NAK1; nuclear hormone receptor NUR/77; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; Testicular receptor 3	WB	Human, Mouse, Rat
	NUR77 Antibody (YA1462) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NUR77.

HY-P81781

	Nuclear Mitotic Apparatus Protein 1 Antibody (YA1526) NMP 22; NUMA; NUMA1; SP H antigen	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Nuclear Mitotic Apparatus Protein 1 Antibody (YA1526) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nuclear Mitotic Apparatus Protein 1.

HY-P86658

	Nuclear Mitotic Apparatus Protein 1 Antibody (YA6350) NMP 22; NUMA; NUMA1; SP H antigen.	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, ELISA, FC	Human, Mouse, Rat
	Nuclear Mitotic Apparatus Protein 1 Antibody (YA6350) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nuclear Mitotic Apparatus Protein 1.

HY-P80705

	HIF1 beta Antibody (YA385) ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor; nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta	WB, IHC-P	Human, Mouse, Rat, Hamster
	HIF1 beta Antibody (YA385) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIF1 beta.

HY-P85750

	HIF1 beta Antibody (YA5442) ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	HIF1 beta Antibody (YA5442) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HIF1 beta.

HY-P85446

	NUP98 Antibody (YA5138) NUP98; ADAR2; nuclear pore complex protein Nup98-Nup96	WB	Human, Mouse, Dog
	NUP98 Antibody (YA5138) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NUP98.

HY-P81479

	Nuclear Matrix Protein p84 Antibody (YA1224) THO Complex Subunit 1; Death domain containing protein p84N5; HPR1; hTREX84; nuclear matrix protein p84; p84N5; THO complex 1; Tho1; Thoc1	IHC-P	Human
	Nuclear Matrix Protein p84 Antibody (YA1224) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nuclear Matrix Protein p84.

HY-P80705A

	HIF1 beta Antibody (YA385)(PBS only) ARNT; BHLHE2; Aryl hydrocarbon receptor nuclear translocator; ARNT protein; Class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor; nuclear translocator; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta	WB, IHC-P	Human, Mouse, Rat, Hamster
	HIF1 beta Antibody (YA385) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HIF1 beta.

HY-P85479

	UHRF1 Antibody (YA5171) UHRF1; ICBP90; NP95; RNF106; E3 ubiquitin-protein ligase UHRF1; Inverted CCAAT box-binding protein of 90 kDa; nuclear protein 95; nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; Transcription factor ICBP90; Ubiquit	WB, ICC/IF	Human
	UHRF1 Antibody (YA5171) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to UHRF1.

HY-P86987

	NEMP1 Antibody (YA6680) nuclear envelope integral membrane protein 1 NEMP1 KIAA0286 TMEM194 TMEM194A	WB, ICC/IF	Mouse, Rat
	NEMP1 Antibody (YA6680) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NEMP1.

HY-P81479A

	Nuclear Matrix Protein p84 Antibody (YA1224)(PBS only) THO Complex Subunit 1; Death domain containing protein p84N5; HPR1; hTREX84; nuclear matrix protein p84; p84N5; THO complex 1; Tho1; Thoc1	IHC-P	Human
	Nuclear Matrix Protein p84 Antibody (YA1224) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nuclear Matrix Protein p84.

HY-P85347

	FRK Antibody (YA5039) FRK; PTK5; RAK; Tyrosine-protein kinase FRK; FYN-related kinase; nuclear tyrosine protein kinase RAK; protein-tyrosine kinase 5	IHC-P, ELISA	Human
	FRK Antibody (YA5039) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FRK.

HY-P810412

	NSD3 Antibody (YA9727) DKFZp667H044, FLJ20353, Histone lysine N methyltransferase NSD3, Histone-lysine N-methyltransferase NSD3, MGC126766, MGC142029, NSD 3, NSD3_HUMAN, nuclear set domain containing 3, nuclear SET domain containing protein 3	WB, FC, IHC-P	Human, Mouse, Rat
	NSD3 Antibody (YA9727) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to NSD3.

HY-P85347A

	FRK Antibody (YA5039)(PBS only) FRK; PTK5; RAK; Tyrosine-protein kinase FRK; FYN-related kinase; nuclear tyrosine protein kinase RAK; protein-tyrosine kinase 5	IHC-P, ELISA	Human
	FRK Antibody (YA5039) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FRK.

HY-P85511

	NFIC Antibody (YA5203) 1110019L22Rik; 1500041O16Rik; AA589446; AI746521; CAAT box transcription factor; CCAAT binding transcription factor; CCAAT box binding transcription factor; CCAAT-box-binding transcription factor; CNFI C; CTF; CTF5; MGC137374; MGC20153; NF I; NF I/C; NF-I/C; NF1 C; NF1-C; NF1C; NFI; NFI-C; NFI/C; NFIC; NFIC_HUMAN; nuclear factor 1; nuclear factor 1 C type; nuclear factor 1 C-type; nuclear factor 1/C; nuclear factor I/C; TGGCA binding protein; TGGCA-binding protein; Transcription factor NFIC.	WB, ICC/IF	Human
	NFIC Antibody (YA5203) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to NFIC.

HY-P86199

	NRF-1 Antibody (YA5891) NRF1; nuclear respiratory factor 1; NRF-1; Alpha palindromic-binding protein; Alpha-pal	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NRF-1 Antibody (YA5891) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NRF-1.

HY-P86997

	Nutm1 Antibody (YA6690) NUT family member 1 antibody; nuclear protein in testis antibody; Nutm1 antibody; Nut antibody;	WB, IHC-P, ICC/IF, IF-Tissue	Human, Mouse, Rat
	Nutm1 Antibody (YA6690) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nutm1.

HY-P810370

	CENPF Antibody (YA9690) AH antigen, Cell cycle dependent 350K nuclear protein, CENF, CENP F, CENP F kinetochore protein, CENP-F, CENPF, CENPF kinetochore protein, CENPF_HUMAN, Centromere protein F 350/400ka	WB, IHC-P	Human, Mouse, Rat
	CENPF Antibody (YA9690) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to CENPF.

HY-P810339

	FOXJ1 Antibody (YA9661) Forkhead box protein J1, Forkhead-related protein FKHL13, Hepatocyte nuclear factor 3 forkhead homolog 4, FKHL13, HFH4	WB, IHC-P, ELISA	Human, Mouse, Rat
	FOXJ1 Antibody (YA9661) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to FOXJ1.

HY-P80749

	MCM2 Antibody (YA705) MCM2; BM28; CCNL1; CDCL1; KIAA0030; DNA replication licensing factor MCM2; Minichromosome maintenance protein 2 homolog; nuclear protein BM28	WB, IHC-F, IHC-P, ICC/IF, FC, IP	Human, Mouse
	MCM2 Antibody (YA705) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCM2.

HY-P85058

	MCM2 Antibody (YA4750) MCM2; BM28; CCNL1; CDCL1; KIAA0030; DNA replication licensing factor MCM2; Minichromosome maintenance protein 2 homolog; nuclear protein BM28	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey
	MCM2 Antibody (YA4750) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to MCM2.

HY-P86690

	PCNA Antibody (YA6382) Cyclin; DNA polymerase delta auxiliary protein; HGCN8729; MGC8367; Mutagen-sensitive 209 protein; Pcna/cyclin; PCNAR; Polymerase delta accessory protein; Proliferating Cell nuclear Antigen	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	PCNA Antibody (YA6382) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PCNA.

HY-P85496

	PRMT6 Antibody (YA5188) ANM6_HUMAN; Chromobox protein homolog 7; FLJ10559; FLJ51477; Heterogeneous nuclear ribonucleoprotein methyltransferase like protein 6; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase like 6.; HRMT1L6; OTTHUMP00000012633; PRMT 6; prmt6; protein arginine methyltransferase 6; protein arginine N methyltransferase 6; protein arginine N-methyltransferase 6.	WB, IHC-P, ICC/IF	Human
	PRMT6 Antibody (YA5188) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PRMT6.

HY-P87162

	hnRNP A2B1 Antibody (YA6855) Heterogeneous nuclear ribonucleoprotein A2 antibody; Heterogeneous nuclear ribonucleoprotein A2/B1 antibody; Heterogeneous nuclear ribonucleoprotein B1 antibody; Heterogeneous nuclear ribonucleoproteins A2/B1 antibody; hnRNP A2 / hnRNP B1 antibody; hnRNP A2 antibody; hnRNP A2/B1 antibody; hnRNP B1 antibody; hnRNP-A2 antibody; hnRNP-B1 antibody; Heterogeneous nuclear ribonucleoprotein A2 antibody; Heterogeneous nuclear ribonucleoprotein A2/B1 antibody; Heterogeneous nuclear ribonucleoprotein B1 antibody; Heterogeneous nuclear ribonucleoproteins A2/B1 antibody; hnRNP A2 / hnRNP B1 antibody; hnRNP A2 antibody; hnRNP A2/B1 antibody; hnRNP B1 antibody; hnRNP-A2 antibody; hnRNP-B1 antibody; hnRNPA2 antibody; Hnrnpa2b1 antibody; hnRNPB1 antibody; HNRPA2 antibody; HNRPA2B1 antibody; HNRPB1 antibody; nuclear ribonucleoprotein particle A2 protein antibody; RNP A2 antibody; RNP B1 antibody; RNP-A2 antibody; RNP-B1 antibody; RNPA2 antibody; RNPB1 antibody; ROA2_HUMAN antibody; SNRPB1 antibody;	WB, IHC-P, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat
	hnRNP A2B1 Antibody (YA6855) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to hnRNP A2B1.

HY-P82159

	ILF3 Antibody (YA1904) ILF3; DRBF; MPHOSPH4; NF90; Interleukin enhancer-binding factor 3; Double-stranded RNA-binding protein 76; DRBP76; M-phase phosphoprotein 4; MPP4; nuclear factor associated with dsRNA; NFAR; nuclear factor of activated T-cells 90 kDa; NF-AT-90; Translational control protein 80; TCP80	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse
	ILF3 Antibody (YA1904) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ILF3.

HY-P83284

	hnRNP G Antibody (YA3029) RBMX; HNRPG; RBMXP1; RNA-binding motif protein; X chromosome; Glycoprotein p43; Heterogeneous nuclear ribonucleoprotein G; hnRNP G	WB, IHC-F, IHC-P, ICC/IF	Human
	hnRNP G Antibody (YA3029) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to hnRNP G.

HY-P82093

	hnRNP Q Antibody (YA1838) SYNCRIP; HNRPQ; NSAP1; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding; cytoplasmic RNA-interacting protein	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	hnRNP Q Antibody (YA1838) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to hnRNP Q.

HY-P83240

	Rad21 Antibody (YA2985) RAD21; HR21; KIAA0078; NXP1; Double-strand-break repair protein rad21 homolog; hHR21; nuclear matrix protein 1; NXP-1; SCC1 homolog	WB, FC	Human, Mouse, Rat
	Rad21 Antibody (YA2985) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rad21.

HY-P85460

	PRMT6 Antibody (YA5152) PRMT6; HRMT1L6; protein arginine N-methyltransferase 6; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	PRMT6 Antibody (YA5152) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PRMT6.

HY-P86621

	Rad21 Antibody (YA6313) RAD21; HR21; KIAA0078; NXP1; Double-strand-break repair protein rad21 homolog; hHR21; nuclear matrix protein 1; NXP-1; SCC1 homolog	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Rad21 Antibody (YA6313) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Rad21.

HY-P810586

	Phospho-MCM2 (Ser41) Antibody (YA9850) MCM2; BM28; CCNL1; CDCL1; KIAA0030; DNA replication licensing factor MCM2; Minichromosome maintenance protein 2 homolog; nuclear protein BM28	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
	Phospho-MCM2 (Ser41) Antibody (YA9850) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-MCM2 (Ser41).

HY-P810587

	Phospho-MCM2 (Ser108) Antibody (YA9851) MCM2; BM28; CCNL1; CDCL1; KIAA0030; DNA replication licensing factor MCM2; Minichromosome maintenance protein 2 homolog; nuclear protein BM28	WB, IHC-P	Human, Mouse, Rat
	Phospho-MCM2 (Ser108) Antibody (YA9851) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-MCM2 (Ser108).

HY-P810588

	Phospho-MCM2 (Ser27) Antibody (YA9852) MCM2; BM28; CCNL1; CDCL1; KIAA0030; DNA replication licensing factor MCM2; Minichromosome maintenance protein 2 homolog; nuclear protein BM28	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat
	Phospho-MCM2 (Ser27) Antibody (YA9852) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-MCM2 (Ser27).

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-162946

Alkyne-P60		Alkynes
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a *ligand for target protein* for PROTAC** (HY-162943).

HY-126943

SAHA-BPyne		Alkynes
SAHA-BPyne is an activity-based protein profiling (ABPP) probe for detecting HDAC activity, which covalently labels the proximal proteins through a photoactivation. SAHA-BPyne inhibits HDAC activity in HeLa nuclear lysate with an IC₅₀ of less than 5 μM .

Cat. No.	Product Name		Classification

HY-147081

AS 1411 2 Publications Verification AGRO-100		Aptamers
AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity .

HY-174575

Human MYOD1 mRNA		mRNA Transcription Factors
Human MYOD1 mRNA encodes the human myogenic differentiation 1 (MYOD1) protein, a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. MYOD1 acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.

HY-174794

Cas9-T2A-GFP mRNA		mRNA Gene Editing
The Cas9-T2A-GFP mRNA encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and a green fluorescent protein (GFP), which could be used in genome engineering experiments.

HY-174793

Cas9-T2A-GFP mRNA (N1-Methylpseudo-UTP)		mRNA Gene Editing
The Cas9-T2A-GFP mRNA encodes a Cas9 nuclease gene with two nuclear localization signals (NLS) and a green fluorescent protein (GFP), which could be used in genome engineering experiments. The incorporation of N1-Methylpseudo-UTP can reduce the immunogenicity of the resulting mRNA.

HY-174499

Cas9 Nickase D10A mRNA (5moU)		mRNA Gene Editing
Cas9 Nickase D10A mRNA expresses a version of the Streptococcus pyogenes SF370 Cas9 protein (CRISPR Associated Protein 9) that contains a D10A amino acid substitution. This mRNA also contains a C-terminal nuclear localization signal followed by a HA tag.Cas9 functions as part of the CRISPR (clustered regularly interspaced short palindromic repeats) genome editing system. In the CRISPR system, an RNA guide sequence targets the site of interest and the Cas9 protein is employed to perform the DNA cleavage. While wild-type Cas9 creates a double-stranded break at the target site, Cas9 nickase creates a single-stranded break. This favors homology-directed repair and decreases the occurrence of non-homologous end joining.

HY-174569

Human NFKB1 mRNA		mRNA
Human NFKB1 mRNA encodes the human nuclear factor kappa B subunit 1 (NFKB1) protein, a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection.

HY-174792

Cre-T2A-GFP mRNA		mRNA Gene Editing
The Cre-T2A-GFP mRNA is a capped and polyadenylated messenger RNA encoding a Cre recombinase with a nuclear localization sequence (NLS) and a green fluorescent protein (GFP).

HY-174568

Human NFKB2 mRNA		mRNA Transcription Factors
Human NFKB2 mRNA encodes the human nuclear factor kappa B subunit 2 (NFKB2) protein, a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. NFKB2 can function as either a transcriptional activator or repressor depending on its dimerization partner.

HY-174505

Human YAP1 mRNA		mRNA Transcription Factors
Human YAP1 mRNA encodes the human Yes1 associated transcriptional regulator (YAP1) protein, a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. YAP1 is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment.

HY-174523

Human TLR5 mRNA		mRNA
Human TLR5 mRNA encodes the human toll like receptor 5 (TLR5) protein, a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR5 recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes.

HY-174577

Human MYC mRNA		mRNA Transcription Factors
Human MYC mRNA encodes the human MYC proto-oncogene, bHLH transcription factor (MYC) protein, a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation.

HY-174791

Cre-T2A-GFP mRNA (N1-Methylpseudo-UTP)		mRNA Gene Editing
The Cre-T2A-GFP mRNA is a capped and polyadenylated messenger RNA encoding a Cre recombinase with a nuclear localization sequence (NLS) and a green fluorescent protein (GFP). The incorporation of N1-Methylpseudo-UTP can reduce the immunogenicity of the resulting mRNA.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

nuclear protein

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Natural
Products