5 Results for "

pannexin/connexin hemichannel blocker

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "pannexin/connexin hemichannel blocker" in MCE Product Catalog:

5
Gap19
Gap19
0 Images
5 Cited Publications
Cat. No.: HY-P1136
CAS No.: 1507930-57-5
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .
loading...
    loading...
View All Sizes
5
Gap19 TFA
Gap19 TFA
0 Images
5 Cited Publications
Cat. No.: HY-P1136A
Target:  

Gap Junction Protein

Research Areas:  

Cardiovascular Disease

Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .
loading...
    loading...
View All Sizes
1
Boldine
Boldine
0 Images
1 Cited Publications
Cat. No.: HY-N6973
CAS No.: 476-70-0
Category:  

Alkaloids Lauraceae Extract Phenols Polyphenols Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology  Litsea cubeba (Lour.) Pers.

Target:  

Telomerase Gap Junction Protein P2X Receptor Calcium Channel Reactive Oxygen Species (ROS) NF-κB SGK TNF Receptor

Boldine is an aporphine alkaloid telomerase (telomerase) inhibitor (IC50 of 0.17 μM for TERT) and a pannexin/connexin hemichannel blocker, with oral activity and blood-brain barrier permeability. Boldine inhibits telomerase activity through direct interaction with the telomerase ribonucleoprotein and non-competitive binding near the TERT active site, and downregulates hTERT mRNA while shifting alternative splicing toward non-functional transcripts. Boldine blocks Panx1, Cx43, Cx26, and Cx30 hemichannels as well as P2X7 receptor-mediated calcium influx. Boldine exhibits antioxidant, anti-inflammatory, antiproliferative, and cytotoxic activities by scavenging ROS, inhibiting NFκB, dephosphorylating SGK1, and reducing TNF-alpha levels. Boldine can be used in research on breast cancer, Alzheimer's disease, glioblastoma, diabetes, and spinal cord injury .
loading...
    loading...
View All Sizes
Boldine (Standard)
Boldine (Standard)
0 Images
Cat. No.: HY-N6973R
CAS No.: 476-70-0
Category:  

Alkaloids Lauraceae Extract Phenols Plants Disease Research Fields Inflammation/Immunology  Litsea cubeba (Lour.) Pers.

Target:  

Reference Standards Telomerase Gap Junction Protein P2X Receptor Calcium Channel Reactive Oxygen Species (ROS) NF-κB SGK TNF Receptor

Boldine (Standard) is the analytical standard of Boldine (HY-N6973). This product is intended for research and analytical applications. Boldine is an aporphine alkaloid telomerase (telomerase) inhibitor (IC50 of 0.17 μM for TERT) and a pannexin/connexin hemichannel blocker, with oral activity and blood-brain barrier permeability. Boldine inhibits telomerase activity through direct interaction with the telomerase ribonucleoprotein and non-competitive binding near the TERT active site, and downregulates hTERT mRNA while shifting alternative splicing toward non-functional transcripts. Boldine blocks Panx1, Cx43, Cx26, and Cx30 hemichannels as well as P2X7 receptor-mediated calcium influx. Boldine exhibits antioxidant, anti-inflammatory, antiproliferative, and cytotoxic activities by scavenging ROS, inhibiting NFκB, dephosphorylating SGK1, and reducing TNF-alpha levels. Boldine can be used in research on breast cancer, Alzheimer's disease, glioblastoma, diabetes, and spinal cord injury .
loading...
    loading...
View All Sizes
Boldine hydrochloride
Boldine hydrochloride
0 Images
Cat. No.: HY-W683756
CAS No.: 16625-69-7
Target:  

Telomerase Gap Junction Protein P2X Receptor Calcium Channel Reactive Oxygen Species (ROS) NF-κB SGK TNF Receptor

Research Areas:  

Neurological Disease Metabolic Disease Cancer

Boldine hydrochloride is an aporphine alkaloid telomerase (telomerase) inhibitor (IC50 of 0.17 μM for TERT) and a pannexin/connexin hemichannel blocker, with oral activity and blood-brain barrier permeability. Boldine hydrochloride inhibits telomerase activity through direct interaction with the telomerase ribonucleoprotein and non-competitive binding near the TERT active site, and downregulates hTERT mRNA while shifting alternative splicing toward non-functional transcripts. Boldine hydrochloride blocks Panx1, Cx43, Cx26, and Cx30 hemichannels as well as P2X7 receptor-mediated calcium influx. Boldine hydrochloride exhibits antioxidant, anti-inflammatory, antiproliferative, and cytotoxic activities by scavenging ROS, inhibiting NFκB, dephosphorylating SGK1, and reducing TNF-alpha levels. Boldine hydrochloride can be used in research on breast cancer, Alzheimer's disease, glioblastoma, diabetes, and spinal cord injury .
loading...
    loading...
View All Sizes
Assay Types