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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
porphobilinogen
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "porphobilinogen" in MCE Product Catalog:
Cat. No.: HY-W013495
CAS No.: 487-90-1
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
1
Target:
Research Areas:
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran can be used for the research of acute hepatic porphyria (AHP) .
1
1 Cited Publications
Synonyms: ALN-AS1 sodium
Target:
Research Areas:
Givosiran (ALN-AS1) sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran sodium demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran sodium can be used for the research of acute hepatic porphyria (AHP) .
Cat. No.: HY-W013495S
Cat. No.: HY-W753207
Cat. No.: HY-P70269A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMBS; Porphyria, Acute; Chester Type; Prev. PBGD; PBG-D; Prev. UPS; Uroporphyrinogen I Synthetase; Prev. PORC; LENCEP; porphobilinogen Deaminase; ENCEP; Pre-Uroporphyrinogen Synthase; Hydroxymethylbilane Synthase; Uroporphyrinogen I Synthase
Species:
Human
Source:
E. coli
Cat. No.: HY-P70269
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HMBS; Porphyria, Acute; Chester Type; Prev. PBGD; PBG-D; Prev. UPS; Uroporphyrinogen I Synthetase; Prev. PORC; LENCEP; porphobilinogen Deaminase; ENCEP; Pre-Uroporphyrinogen Synthase; Hydroxymethylbilane Synthase; Uroporphyrinogen I Synthase
Species:
Human
Source:
HEK293
Cat. No.: HY-P70269Y
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: HMBS; Porphyria, Acute; Chester Type; Prev. PBGD; PBG-D; Prev. UPS; Uroporphyrinogen I Synthetase; Prev. PORC; LENCEP; porphobilinogen Deaminase; ENCEP; Pre-Uroporphyrinogen Synthase; Hydroxymethylbilane Synthase; Uroporphyrinogen I Synthase
Species:
Human
Source:
HEK293
Cat. No.: HY-165581
CAS No.: 80037-86-1
Target:
Research Areas:
Succinylacetone pyrrole is a potent inhibitor of δ-aminolevulinic acid dehydratase (ALA dehydratase) with a Ki value of 5 μM. Succinylacetone pyrrole blocks the biosynthetic pathway from ALA to porphobilinogen (PBG) and subsequent porphyrins or corrinoids by competitively binding to ALA dehydratase and inhibiting its activity. Succinylacetone pyrrole can be used for studies on vitamin B12 biosynthesis and its regulatory mechanisms .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
