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Results for "

porphobilinogen

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) Endogenous Metabolite (3) Isotope-Labeled Compounds (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Metabolic Disease (5)
Oligonucleotides:	siRNA drugs (2) siRNAs (2)

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Recombinant Proteins

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-132610A

Givosiran sodium 1 Publications Verification ALN-AS1 sodium	Small Interfering RNA (siRNA)	Metabolic Disease
Givosiran (ALN-AS1) sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran sodium demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran sodium can be used for the research of acute hepatic porphyria (AHP) .

HY-132610

Givosiran 1 Publications Verification ALN-AS1	Small Interfering RNA (siRNA)	Metabolic Disease
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran can be used for the research of acute hepatic porphyria (AHP) .

HY-W013495

*Porphobilinogen*	Endogenous Metabolite	Metabolic Disease
Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.

HY-W013495S

Porphobilinogen-13C2	Endogenous Metabolite	Metabolic Disease
Porphobilinogen- ¹³C₂ is the ¹³C-labeled Porphobilinogen. Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.

HY-W753207

Porphobilinogen-13C2,15N	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Porphobilinogen- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled Porphobilinogen (HY-W013495). Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.

HY-W681749

Morphactin Chlorflurenol methyl Morphactin	Biochemical Assay Reagents	Others
Morphactin Chlorflurenol methyl (Morphactin) is a plant growth regulator. Morphactin Chlorflurenol methyl preserves chlorophyll and suppresses senescence. Morphactin Chlorflurenol methyl regulates chlorophyll metabolic enzymes and alleviates heat-induced leaf senescence by enhancing chlorophyll content and reducing electrolyte leakage. Morphactin Chlorflurenol methyl promotes shoot redifferentiation and tracheary element development in tobacco calluses. Morphactin Chlorflurenol methyl can be applied to the investigation of heat-induced leaf senescence .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-W013495

*Porphobilinogen*	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.

Species:	Human (3)
Tag:	His (3)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P70269A

	*HMBS/Porphobilinogen* deaminase Protein, Human (N-His)** porphobilinogen deaminase; PBG-D; Hydroxymethylbilane synthase (HMBS); Pre-uroporphyrinogen synthase	Human	E. coli
	HMBS (porphobilinogen deaminase) is key to heme biosynthesis, catalyzing the sequential polymerization of four porphobilinogen molecules to form hydroxymethylbiphenyl. The process begins with dipyrromethane cofactor assembly derived from porphobilinogen or preuroporphyrinogen and promoted by apoenzymes. HMBS/Porphobilinogen deaminase Protein, Human (N-His) is the recombinant human-derived HMBS/Porphobilinogen deaminase protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70269

	*HMBS/Porphobilinogen* deaminase Protein, Human (HEK293, His)** rHuporphobilinogen deaminase/HMBS, His; porphobilinogen Deaminase; PBG-D; Hydroxymethylbilane Synthase; HMBS; Pre-Uroporphyrinogen Synthase; HMBS; PBGD; UPS	Human	HEK293
	HMBS (porphobilinogen deaminase) is key to heme biosynthesis, catalyzing the sequential polymerization of four porphobilinogen molecules to form hydroxymethylbiphenyl. The process begins with dipyrromethane cofactor assembly derived from porphobilinogen or preuroporphyrinogen and promoted by apoenzymes. HMBS/Porphobilinogen deaminase Protein, Human (HEK293, His) is the recombinant human-derived HMBS/Porphobilinogen deaminase protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70269Y

	*HMBS/Porphobilinogen* deaminase Protein, Human (HEK293, His, solution)** rHuporphobilinogen deaminase/HMBS, His; porphobilinogen Deaminase; PBG-D; Hydroxymethylbilane Synthase; HMBS; Pre-Uroporphyrinogen Synthase; HMBS; PBGD; UPS	Human	HEK293
	HMBS (porphobilinogen deaminase) is key to heme biosynthesis, catalyzing the sequential polymerization of four porphobilinogen molecules to form hydroxymethylbiphenyl. The process begins with dipyrromethane cofactor assembly derived from porphobilinogen or preuroporphyrinogen and promoted by apoenzymes. HMBS/Porphobilinogen deaminase Protein, Human (HEK293, His, solution) is the recombinant human-derived HMBS/Porphobilinogen deaminase protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	상품명	Chemical Structure

HY-W013495S

Porphobilinogen-13C2
Porphobilinogen- ¹³C₂ is the ¹³C-labeled Porphobilinogen. Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.

HY-W753207

Porphobilinogen-13C2,15N
Porphobilinogen- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled Porphobilinogen (HY-W013495). Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.

Cat. No.	상품명		Classification

HY-132610A

Givosiran sodium 1 Publications Verification ALN-AS1 sodium		siRNAs siRNA drugs
Givosiran (ALN-AS1) sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran sodium demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran sodium can be used for the research of acute hepatic porphyria (AHP) .

HY-132610

Givosiran 1 Publications Verification ALN-AS1		siRNAs siRNA drugs
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran can be used for the research of acute hepatic porphyria (AHP) .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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