country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-165581

Copy Link Print Information

Succinylacetone pyrrole

Succinylacetone pyrrole is a potent inhibitor of δ-aminolevulinic acid dehydratase (ALA dehydratase) with a K_i value of 5 μM. Succinylacetone pyrrole blocks the biosynthetic pathway from ALA to porphobilinogen (PBG) and subsequent porphyrins or corrinoids by competitively binding to ALA dehydratase and inhibiting its activity. Succinylacetone pyrrole can be used for studies on vitamin B12 biosynthesis and its regulatory mechanisms.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 80037-86-1
화학식: C₁₂H₁₅NO₅
분자량:253.25

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Succinylacetone pyrrole Chemical Structure

CAS No.: 80037-86-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Carbonic Anhydrase Isoforms :

In Vitro

Succinylacetone pyrrole (18 h) inhibits corrinoid synthesis in Clostridium tetanomorphum cells. Treatment with 1.1 μM Succinylacetone pyrrole reduces corrinoid production by 49%, and a concentration of 8.2 μM reduces it by 83%^[1].
Succinylacetone pyrrole (2-10 μM) exerts an inhibitory effect on porphyrin formation in Staphylococcus epidermis, with approximately 50% inhibition observed at 4 μM^[1].
Succinylacetone pyrrole potently inhibits purified ALA dehydratase from Clostridium tetanomorphum via a competitive binding mechanism, with a K_i value of 5 μM [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 80037-86-1
분자량 253.25
화학식 C₁₂H₁₅NO₅
SMILES

O=C(O)CCC(=O)C1=C(NC=C1CCC(=O)O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Brumm PJ, et al. Succinylacetone pyrrole, a powerful inhibitor of vitamin B12 biosynthesis: effect of delta-aminolevulinic acid dehydratase. Biochem Biophys Res Commun. 1981 Oct 15;102(3):854-9.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기