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Cat. No.: HY-165581

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Succinylacetone pyrrole

Succinylacetone pyrrole is a potent inhibitor of δ-aminolevulinic acid dehydratase (ALA dehydratase) with a K_i value of 5 μM. Succinylacetone pyrrole blocks the biosynthetic pathway from ALA to porphobilinogen (PBG) and subsequent porphyrins or corrinoids by competitively binding to ALA dehydratase and inhibiting its activity. Succinylacetone pyrrole can be used for studies on vitamin B12 biosynthesis and its regulatory mechanisms.

For research use only. We do not sell to patients.

CAS No.: 80037-86-1
Formula: C₁₂H₁₅NO₅
Molecular Weight:253.25

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Please store the product under the recommended conditions in the Certificate of Analysis.

Succinylacetone pyrrole Chemical Structure

CAS No.: 80037-86-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All Carbonic Anhydrase Isoforms :

In Vitro

Succinylacetone pyrrole (18 h) inhibits corrinoid synthesis in Clostridium tetanomorphum cells. Treatment with 1.1 μM Succinylacetone pyrrole reduces corrinoid production by 49%, and a concentration of 8.2 μM reduces it by 83%^[1].
Succinylacetone pyrrole (2-10 μM) exerts an inhibitory effect on porphyrin formation in Staphylococcus epidermis, with approximately 50% inhibition observed at 4 μM^[1].
Succinylacetone pyrrole potently inhibits purified ALA dehydratase from Clostridium tetanomorphum via a competitive binding mechanism, with a K_i value of 5 μM [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 80037-86-1
Molecular Weight 253.25
Formula C₁₂H₁₅NO₅
SMILES

O=C(O)CCC(=O)C1=C(NC=C1CCC(=O)O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Brumm PJ, et al. Succinylacetone pyrrole, a powerful inhibitor of vitamin B12 biosynthesis: effect of delta-aminolevulinic acid dehydratase. Biochem Biophys Res Commun. 1981 Oct 15;102(3):854-9.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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