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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
rat primary cortical neurons
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "rat primary cortical neurons" in MCE Product Catalog:
Cat. No.: HY-P10360
CAS No.: 2816095-52-8
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Cat. No.: HY-139012
CAS No.: 2584411-87-8
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RC574 is a GPx1 and GPx4 modulator that increases GPx1 protein levels and enzyme activity and protects cells against RSL3-induced GPx4 inactivation and ferroptosis. RC574 inhibits glutamate-induced ferroptosis/oxytosis, mitochondrial superoxide anion production, mitochondrial membrane hyperpolarization, oxidant production, and mitochondrial fragmentation. RC574 protects primary cortical neurons against glutamate challenge and inhibits mitochondrial superoxide anion production while increasing antioxidant enzyme activity. RC574 ameliorates motor-related behavioral deficits and reduces reactive astrocytes in the striatum in a rat model of ischemic stroke. RC574 can be used in research on neurodegenerative diseases and ischemic stroke .
Cat. No.: HY-178153
CAS No.: 1204572-46-2
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BPAM363 is an orally active, selective positive allosteric modulator (PAM) of AMPARs with blood-brain barrier penetration. BPAM363 selectively potentiates AMPAR activity in human and rat models, with an EC2x value of 0.96 μM in rat embryonic cortex primary neurons. BPAM363 upregulates BDNF protein expression in rat primary cortical neuronal cultures. BPAM363 enhances AMPA-mediated excitatory postsynaptic responses in rat and mice. BPAM363 can be used for the study of cognitive disorders .
Cat. No.: HY-100458
CAS No.: 2185855-51-8
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SCR-4026 is a neuroprotective agent with blood-brain barrier penetration ability. SCR-4026 exerts neuroprotective effects by disrupting the interaction between neuronal nNOS and PSD9, with an IC50 of 6.3 μM. SCR-4026 alleviates N-methyl-D-aspartate (NMDA)-induced excitotoxic damage in primary cortical neurons, and also protects neurons in the oxygen-glucose deprivation (OGD) model. SCR-4026 can reduce the cerebral infarct volume in the rat middle cerebral artery occlusion (MCAO) reperfusion model. SCR-4026 can be used for the study of stroke .
Cat. No.: HY-180345
CAS No.: 855170-53-5
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ND-7001 is an inhibitor of PDE2 with an IC50 of 0.05 μM. ND-7001 exhibits good selectivity agianst PDE3 and PDE4. ND-7001 increases cGMP levels in primary neuronal cultures of rat cerebral cortical neurons. ND-7001 displays anxiolytic effects .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
