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Results for "

sesquiterpene compound

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5 alpha Reductase (2) Akt (2) AMPK (1) Antibiotic (1) Apoptosis (6) Bacterial (5) Biochemical Assay Reagents (1) Calcium Channel (1) Caspase (1) CCR (1) DNA/RNA Synthesis (1) Drug Derivative (3) Fluorescent Dye (1) Fungal (2) GLUT (1) GSK-3 (1) IFNAR (1) Influenza Virus (2) Insecticide (1) Interleukin Related (1) Keap1-Nrf2 (2) Lactate Dehydrogenase (2) LIM Kinase (LIMK) (1) mTOR (1) Na+/K+ ATPase (1) NF-κB (5) NO Synthase (7) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (2) PEPCK (1) PI3K (1) Reactive Oxygen Species (ROS) (4) Reference Standards (1) Sirtuin (1) SOD (1) STAT (1) TNF Receptor (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (3) Endocrinology (2) Infection (11) Inflammation/Immunology (17) Metabolic Disease (4) Neurological Disease (6)

By Targets:

5 alpha Reductase (2)

Akt (2)

AMPK (1)

Antibiotic (1)

Apoptosis (6)

Bacterial (5)

Biochemical Assay Reagents (1)

Calcium Channel (1)

Caspase (1)

CCR (1)

DNA/RNA Synthesis (1)

Drug Derivative (3)

Fluorescent Dye (1)

Fungal (2)

GLUT (1)

GSK-3 (1)

IFNAR (1)

Influenza Virus (2)

Insecticide (1)

Interleukin Related (1)

Keap1-Nrf2 (2)

Lactate Dehydrogenase (2)

LIM Kinase (LIMK) (1)

mTOR (1)

Na+/K+ ATPase (1)

NF-κB (5)

NO Synthase (7)

Nuclear Factor of activated T Cells (NFAT) (1)

p38 MAPK (2)

PEPCK (1)

PI3K (1)

Reactive Oxygen Species (ROS) (4)

Reference Standards (1)

Sirtuin (1)

SOD (1)

STAT (1)

TNF Receptor (1)

By Research Areas:

Cancer (17)

Cardiovascular Disease (3)

Endocrinology (2)

Infection (11)

Inflammation/Immunology (17)

Metabolic Disease (4)

Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6018

β-Eudesmol 1 Publications Verification	Caspase TNF Receptor SOD Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
β-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. β-Eudesmol is a neostigmine antagonist. β-Eudesmol can antagonize neostigmine-induced neuromuscular failure. β-Eudesmoll can be used in the study of sepsis diseases. β-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea .

HY-N3651

Curzerenone 1 Publications Verification	Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt mTOR	Infection Cancer
Curzerenone is an orally active sesquiterpene compound and Antibacterial agent. Curzerenone can be isolated from Curcuma zedoaria and Curcuma aeruginosa plants. Curzerenone increases ROS levels, activates Apoptotic signaling pathways, and attenuates the PI3K/AKT/mTOR signaling pathway. Curzerenone exhibits anticancer activity against liver cancer and cervical cancer. Curzerenone has antioxidant effects. Curzerenone shows weak antibacterial activity against Escherichia coli. Curzerenone can be used in research related to hepatocellular carcinoma, cervical cancer, and Escherichia coli infection .

HY-N0440

Germacrone 2 Publications Verification	Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis	Infection Neurological Disease Inflammation/Immunology Endocrinology Cancer
Germacrone is a sesquiterpene compound with multiple biological activities. Germacrone inhibits the H1N1 and H3N2 inﬂuenza A virus and the inﬂuenza B virus. Germacrone blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone inhibits 5α-reductase and has anti-androgenic effect. Germacrone has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone also has antioxidant activity .

HY-N7912

Pterosin A (2S)-Pterosin A	AMPK PEPCK GSK-3 GLUT Akt p38 MAPK Reactive Oxygen Species (ROS)	Metabolic Disease
Pterosin A ((2S)-Pterosin A) is a sesquiterpene compound. Pterosin A is an orally active AMPK activator with anti-diabetic effect. Pterosin A can promote glucose uptake, increase serum insulin, and improve hyperglycemia and glucose intolerance. Pterosin A can prevent insulin-secreting cells death and reduce ROS production. Pterosin A can be used for the research of metabolic disease, such as diabetes .

HY-N10116A

Calamenene	Interleukin Related IFNAR Calcium Channel Bacterial CCR	Infection Cancer
Calamenene is a sesquiterpene compound . Calamenene promotes dendritic cell maturation, upregulates CD1a, CD80, CD83, CD86, HLA-DR and CCR7 on the cell surface, reduces endocytic activity, enhances T cell-stimulating capacity, drives Th1 polarization through the secretion of IL-12, induces IFN-γ production, decreases IL-4 generation, and triggers intracellular Ca ²⁺ mobilization as well as dendritic cell migration towards MIP-3β. Calamenene exerts bacteriostatic and bactericidal growth-inhibitory effects against pathogenic Vibrio harveyi. Calamenene can be used in studies related to cancer and bacterial infections .

HY-N10483

Telekin	Apoptosis	Cancer
Telekin is an eucalyptus-type sesquiterpene lactone compound found in Carpesium divaricatum. Telekin can activate mitochondria-mediated cell apoptosis and has anticancer activity .

HY-122295

Dehydroleucodine	Apoptosis	Inflammation/Immunology Cancer
Dehydroleucodine is a sesquiterpene lactone isolated from Artemisia douglasiana. Dehydroleucodine is a mast cell stabilizer that inhibits tmast cell degranulation induced by compound 48/80. Dehydroleucodine inudces cells apoptosis, and has gastric ulcer inhibition and antileukemic effects .

HY-N0440R

Germacrone (Standard)	Reference Standards Influenza Virus NF-κB 5 alpha Reductase Keap1-Nrf2 Lactate Dehydrogenase Apoptosis	Infection Neurological Disease Inflammation/Immunology Endocrinology Cancer
Germacrone (Standard) is an analytical standard of Gemmacrone (HY-N0440). This product is intended for research and analytical applications. Germacrone (Standard) is a sesquiterpene compound with multiple biological activities. Germacrone (Standard) inhibits the H1N1 and H3N2 inﬂuenza A viruses and the inﬂuenza B virus. Germacrone (Standard) blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone (Standard) can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone (Standard) inhibits 5α-reductase and has anti-androgenic effect. Germacrone (Standard) has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone (Standard) also has antioxidant activity .

HY-N2240

Eupalinolide K	STAT	Cancer
Eupalinolide K, a sesquiterpene lactones compound from Eupatorium lindleyanum, is a STAT3 inhibitor. Eupalinolide K is a Michael reaction acceptor (MRA) .

HY-N10912

Shizukanolide	Others	Infection
Shizukanolide, a sesquiterpene lactone, can be isolated from Chloranthus japonicus (Chloranthaceae). The dehydro-compound of Shizukanolide, shows moderate antifungal activity .

HY-N11261

α-Selinene	Drug Derivative	Others
α-Selinene is a natural product that can be extracted from Psidium guajava L.. α-Selinene is a sesquiterpene compound with volatility .

HY-N10847

1-O-Acetyl-6beta-O-Isobutyrylbritannilactone	Others	Cancer
1-O-Acetyl-6beta-O-Isobutyrylbritannilactone (compound 5), a sesquiterpene lactone, can be isolated from the flowers of Inula britannica. 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone shows significant cytotoxicity to tumor cells .

HY-N16513

Muurol-4-ene-3,8-dione	Others	Metabolic Disease
Muurol-4-ene-3,8-dione (Compound 2), a sesquiterpene, is one of the main hepatotoxic components in Eupatorium adenophorum. Muurol-4-ene-3,8-dione has an inhibitory effect on the growth of both the normal human hepatocyte cell L02 and the human hepatocellular carcinoma cell HepG2 with IC₅₀ values of 87.52 and 104.48 μM .

HY-122915

Zedoarondiol	Reactive Oxygen Species (ROS)	Cardiovascular Disease
Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research .

HY-W1121877

Cedrenol	Others	Others
Cedrenol is a sesquiterpene alcohol compound found in Juniperus virginiana .

HY-N12039

Juniper camphor	Others	Others
Juniper camphor is a sesquiterpene compound isolated from camphor blue oil, the high-boiling fraction of camphor .

HY-N15640

Filiformin (-)-Filiformin	Bacterial	Infection Inflammation/Immunology Cancer
Filiformin ((-)-Filiformin) is a sesquiterpene compound that can be isolated from Laurencia filiformis forma heteroclada. Filiformin exhibits certain cytotoxicity against P388 and BSC-1 cells. Filiformin has antimicrobial activity against Bacillus subtilis, Trichophyton mentagrophytes and Candida albicans. In addition, Filiformin can inhibit oxygen uptake in isolated rat liver mitochondria at a concentration of 150 μM .

HY-N11706

β-Cedrene (+)-β-Cedrene	Fungal	Infection Inflammation/Immunology
β-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a K_i value of 1.6 μM .

HY-N15600

Merulidial (-)-Merulidial	Antibiotic Fungal Bacterial DNA/RNA Synthesis	Infection Cancer
Merulidial (Compound 1) is an antibiotic and cytotoxic agent with a sesquiterpene dialdehyde structure. Merulidial significantly inhibits the germination of spores and the hyphal growth of the wood-roting basidiomycete Heterobasidion annosum (H. annosum) and the saprophytic mould Cladosporium cucumerinum (C.cucumerinum). Merulidial also inhibits a variety of bacteria, algae and DNA synthesis of ECA cells. Merulidial shows a strong anticancer activity with IC₅₀ s of 20 and 10 μg/mL for ECA and L1210 cells, respectively .

HY-N10868

8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide	LIM Kinase (LIMK)	Cancer
8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide (compound 3), a sesquiterpene, has anti-LIMK1 activity. 8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide has inhibitory property on cell motility .

HY-N9263

Diacetylpiptocarphol	Others	Infection
Diacetylpiptocarphol (compound 4) is a sesquiterpene lactone compound. Diacetylpiptocarphol has anti-leishmaniasis activity .

HY-125949

Kanshone H	Others	Others
Kanshone H (compound 6) is a sesquiterpene compound isolated from the underground parts of spikenard .

HY-N12573

Dendronobilin B	Others	Others
Dendronobilin B is a sesquiterpene compound that can be isolated from Dendrobium crystallinum .

HY-N2769

9β-Hydroxy-ageraphorone	Others	Others
9β-Hydroxy-ageraphorone is a natural cadinene sesquiterpene compound .

HY-N3410

Lacinilene C	Fluorescent Dye	Others
Lacinilene C is a sesquiterpene-like compound isolated from the root of Bombax malabaricum .

HY-N12172

Kissoone A	Others	Others
Kissoone A (compound 1) is a three-membered ring sesquiterpene isolated from valerian root .

HY-N1032

(+)-12α-Hydroxyisodrimenin	Others	Others
(+)-12α-Hydroxyisodrimenin (compound 7) is a drimanic sesquiterpene that can be found in sponge Dysidea fusca .

HY-N3800

Eichlerialactone	Others	Cancer
Eichlerialactone is a sesquiterpene compound isolated from Chisocheton penduliflorus. Eichlerialactone is weakly cytotoxic to breast cancer cells .

HY-N12192

Ebenifoline E-II	Others	Others
Ebenifoline E-II (Compound 2) is a sesquiterpene alkaloid derived from Euonymus laxiflorus. Ebenifoline E-II is cytotoxic .

HY-N11449

Nardoaristolone B	Others	Others
Nardoaristolone B, a non-sesquiterpene compound isolated from the root of Nardostachys jatamansi, has protective effects on cardiomyocyte injury in neonatal rats .

HY-N8864

Isosativenediol	Others	Others
Isosativenediol is a sesquiterpene compound. Isosativenediol can be purified from Cochliobolus sativus, an endophytic fungus isolated from the desert plant Artemisia Desertorum .

HY-N16655

1-Hydroxyacorenone	Others	Neurological Disease
1-Hydroxyacorenone is a sesquiterpene compound that can be isolated from Acorus tatarinowii. 1-Hydroxyacorenone can be used for research on Alzheimer's disease .

HY-N15739

(rel)-ent-Chromazonarol	Biochemical Assay Reagents	Others
(rel)-ent-Chromazonarol is the relative configuration of ent-Chromazonarol and is a sesquiterpene hydroquinone compound. (rel)-ent-Chromazonarol can be isolated from the sponge Disidea pallescens .

HY-N8990

Aristola-1(10),8-dien-2-one	Others	Others
Aristola-1(10),8-dien-2-one is a sesquiterpene compound that can be isolated from rhizome of Nardostachys chinensis of Valerianaceae .

HY-N9121

8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide	Others	Others
8β-(4-Acetoxy-5-hydroxytigloyloxy)costunolide (compound 5) is a sesquiterpene lactone that can be isolated from Stevia alpina var. glutinosa .

HY-N11570

Phaeocaulisin E	Others	Inflammation/Immunology
Phaeocaulisin E (Compound 5) is a guaiane-type sesquiterpene that inhibits LPS HY-(HY-D1056)-induced NO production in RAW 264.7 macrophages with an IC₅₀ of 10.3 μM .

HY-N9159

Piptocarphin F	Others	Cancer
Piptocarphin F (Compound 5) is a sesquiterpene lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell line HL-60 (IC₅₀=5.69 μmol*L ^-1) .

HY-N12131

Ejaponine A	Others	Metabolic Disease
Ejaponine A (Compound 1) is an insecticidal sesquiterpene ester. Ejaponine A is obtained from the natural Euonymus japonicus. Ejaponine A has Mythimna separata killing activity (LD₅₀89.2 μgg ^-1). Ejaponine A is used to kill Mythimna separata .

HY-N12170

Kissoone C	Others	Neurological Disease
Kissoone C (compound 3) is a three-membered ring sesquiterpene isolated from valerian root. Kissoone C can enhance the activity of nerve growth factor (NGF)-mediated neurite outgrowth in PC12D cells .

HY-N12130

Celangulatin D	Insecticide	Others
Celangulatin D (Compound 2) is an insecticidal sesquiterpene polyol ester isolated from the root bark of the natural Celastrus angulatus. Celangulatin D has insecticidal activity against armyworms. Celangulatin D can be used for insecticidal and anti-tumor research .

HY-N1012

(-)-11,13-Dehydroeriolin	Others	Cancer
(-)-11,13-Dehydroeriolin (compound 9), a sesquiterpene lactone, is a nature product that could be isolated from Carpesium abrotanoides L. (-)-11,13-Dehydroeriolin has antiproliferative active. (-)-11,13-Dehydroeriolin can be used in research of cancer .

HY-N8127

*(1(10)E,2R,4R)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one*	Others	Others
(1(10)E,2R,4R)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one (compound 6) is a sesquiterpene .

HY-N15503

Cycloneroside B	NO Synthase	Inflammation/Immunology
Cycloneroside B is a novel sesquiterpene aminoglycoside compound that can be isolated from Trichoderma sp. SCSIOW21. Cycloneroside B has the activity of inhibiting the production of NO, and its IC₅₀ value for inhibiting the production of NO is 50.7 µM. Cycloneroside B can be used in the research of the anti-inflammatory field .

HY-N15502

Cycloneroside A	NO Synthase	Inflammation/Immunology
Cycloneroside A is a sesquiterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Cycloneroside A has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC₅₀ value for inhibiting the production of NO is approximately 100 µM. Cycloneroside A can be used in the research of the anti-inflammatory field .

HY-W670564A

(4S)-10-Nor-calamenen-10-one	NO Synthase	Neurological Disease
(4S)-10-Nor-calamenen-10-one (Compound 15) enhances LPS-induced NO production by microglia. (4S)-10-Nor-calamenen-10-one is an eudesmane sesquiterpene that can be isolated from Alpinia oxyphylla .

HY-N10876

8-epi-Chlorajapolide F	Others	Others
8-epi-Chlorajapolide F (compound 1) a sesquiterpene that can be isolated from the aboveground part of the Chloranthus japonicus. 8-epi-Chlorajapolide has few cytotoxic to human cancer cell lines NCI-H460 and SMMC-7721 (IC₅₀s>50 μg/mL) .

HY-N15505

Cycloneroside D	NO Synthase	Inflammation/Immunology
Cycloneroside D is a novel sesquiterpene aminoglycoside compound discovered from the deep - sea - sediment fungus Trichoderma sp. SCSIOW21. Cycloneroside D has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC₅₀ value for inhibiting the production of NO is 42.0 μM. Cycloneroside D can be used in the research of the anti - inflammatory field .

HY-N18225

β-Curcumene	Sirtuin NF-κB	Inflammation/Immunology
β-Curcumene is a sesquiterpene compound. β-Curcumene has the potential to act as a SIRT1 activator and a NF-κB inhibitor. β-Curcumene possesses a spicy and ginger-like aroma, and can serve as a raw material for flavors, fragrances and cosmetics. β-Curcumene can be used in the research of type 2 diabetes .

HY-N12827

(+)-Frullanolide	Others	Others
(+)-Frullanolide (Compound 2) is a sesquiterpene lactone found in Frullania muscicola .

HY-N13702

Secoaristolenedioic acid	Others	Others
Secoaristolenedioic acid (Compound 1) is a sesquiterpene, which is found in ethanol extract of the roots and rhizomes of Nardostachys chinensis .

Cat. No.	Product Name

HY-L056

Terpenoids Library

768 compounds

Terpenoids, also known as isoprenoids, are the most numerous and structurally diverse natural products found in many plants. Terpenoids are divided into monoterpenes, sesquiterpenes, diterpenes, sesterpenes, and triterpenes depending on its carbon units. Several studies, in vitro, preclinical, and clinical have confirmed that this class of compounds displays a wide array of very important pharmacological properties in the fight against cancer, malaria, inflammation, and a variety of infectious diseases. Naturally occurring terpenoids provide new opportunities to discover new drugs with minimum side effects.

MCE designs a unique collection of 768 terpenoid compounds that all come from natural products. MCE Terpenoids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

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