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Results for "

spontaneously hypertensive rats

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (5) Adrenergic Receptor (13) Aldehyde Dehydrogenase (ALDH) (1) Amine N-methyltransferase (2) Amino Acid Derivatives (1) Aminopeptidase (1) Angiotensin Receptor (4) Angiotensin-converting Enzyme (ACE) (8) Apoptosis (4) Bcl-2 Family (1) Cadherin (1) Calcium Channel (5) Caspase (1) Cyclin G-associated Kinase (GAK) (1) Dopamine Receptor (1) Drug Derivative (3) Endogenous Metabolite (5) Epoxide Hydrolase (1) Ferroptosis (1) Glutathione Peroxidase (1) Guanylate Cyclase (1) Histamine Receptor (3) Keap1-Nrf2 (1) Natriuretic Peptide Receptor (NPR) (1) Neprilysin (1) Neurokinin Receptor (1) Neuropeptide Y Receptor (1) NF-κB (1) NO Synthase (2) Opioid Receptor (1) PARP (1) Phosphodiesterase (PDE) (1) Potassium Channel (1) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (3) Reference Standards (4) ROCK (1) Sodium Channel (1) Somatostatin Receptor (1) Vasopressin Receptor (1) VEGFR (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (53) Inflammation/Immunology (8) Metabolic Disease (6) Neurological Disease (8)

By Targets:

5-HT Receptor (5)

Adrenergic Receptor (13)

Aldehyde Dehydrogenase (ALDH) (1)

Amine N-methyltransferase (2)

Amino Acid Derivatives (1)

Aminopeptidase (1)

Angiotensin Receptor (4)

Angiotensin-converting Enzyme (ACE) (8)

Apoptosis (4)

Bcl-2 Family (1)

Cadherin (1)

Calcium Channel (5)

Caspase (1)

Cyclin G-associated Kinase (GAK) (1)

Dopamine Receptor (1)

Drug Derivative (3)

Endogenous Metabolite (5)

Epoxide Hydrolase (1)

Ferroptosis (1)

Glutathione Peroxidase (1)

Guanylate Cyclase (1)

Histamine Receptor (3)

Keap1-Nrf2 (1)

Natriuretic Peptide Receptor (NPR) (1)

Neprilysin (1)

Neurokinin Receptor (1)

Neuropeptide Y Receptor (1)

NF-κB (1)

NO Synthase (2)

Opioid Receptor (1)

PARP (1)

Phosphodiesterase (PDE) (1)

Potassium Channel (1)

Prostaglandin Receptor (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (4)

ROCK (1)

Sodium Channel (1)

Somatostatin Receptor (1)

Vasopressin Receptor (1)

VEGFR (1)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (53)

Inflammation/Immunology (8)

Metabolic Disease (6)

Neurological Disease (8)

Inhibitors & Agonists

Peptides

Natural
Products

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-W001083

3-Hydroxyphenylacetic acid 1 Publications Verification	Endogenous Metabolite Ferroptosis Glutathione Peroxidase Aldehyde Dehydrogenase (ALDH) Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
3-Hydroxyphenylacetic acid is an orally active flavonoid metabolite produced by intestinal flora, with blood pressure-lowering activity. 3-Hydroxyphenylacetic acid can also inhibit ferroptosis by upregulating the expression of GPX4, thereby improving spermatogenic dysfunction in aged mice. In addition, abnormal levels of 3-Hydroxyphenylacetic acid are closely related to certain diseases, such as autism spectrum disorders .

HY-B0592

Trandolapril RU44570	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Trandolapril (RU44570) is a nonsulfhydryl proagent that is hydrolysed to the active diacid Trandolaprilat. Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that has been used in the treatment of hypertension and congestive heart failure (CHF), and after myocardial infarction (MI) .

HY-W012814

4-Methylcatechol	Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Cancer
4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation .

HY-W005255

3-(3-Hydroxyphenyl)propionic acid	Endogenous Metabolite	Cardiovascular Disease
3-(3-Hydroxyphenyl)propionic acid (3HPPA) is an endothelium-dependent nitric oxide (NO) release promoter and endothelial nitric oxide synthase (eNOS) activator. 3-(3-Hydroxyphenyl)propionic acid activates eNOS to mediate vascular smooth muscle relaxation and enhances endothelial cell NO synthesis, inducing vasodilation and reducing peripheral vascular resistance. 3-(3-Hydroxyphenyl)propionic acid can dose-dependently reduce systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR) without affecting cardiac contractility or heart rate. 3-(3-Hydroxyphenyl)propionic acid has antihypertensive and vascular protective effects and can be used in the prevention and treatment of cardiovascular diseases .

HY-162596

NRL-1049 BA-1049 free base	ROCK	Neurological Disease
NRL-1049 (BA-1049 (free base)) is an orally available and selective ROCK2 inhibitor with IC₅₀ values of 0.59 µM for ROCK2 and 26 µM for ROCK1, respectively. NRL-1049 modulates ROCK signaling, preserves blood-brain barrier integrity, reduces edema, seizures and hemorrhage, and alleviates cerebral cavernous malformation lesion burden. NRL-1049 can be used for the study of acute brain injury, ischemic stroke, and cerebral cavernous malformations .

HY-B1107

Naftidrofuryl oxalate Nafronyl oxalate salt	5-HT Receptor	Cardiovascular Disease
Naftidrofuryl oxalate (Nafronyl oxalate salt) is an orally active 5-HT₂ receptor antagonist. Naftidrofuryl oxalate selectively blocks vascular and platelet 5-HT₂ receptors, inhibiting Serotonin (HY-B1473A)-induced vasoconstriction, platelet aggregation, and vascular smooth muscle cell proliferation. Naftidrofuryl oxalate can be used for the research of intermittent claudication, peripheral occlusive arterial disease, and critical limb ischaemia .

HY-118060

Dipeptide 2 N-Valyltryptophan; Val-Trp	Angiotensin-converting Enzyme (ACE) Calcium Channel NO Synthase	Cardiovascular Disease
Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC₅₀ of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats .

HY-100554

BMY 7378 2 Publications Verification	Adrenergic Receptor 5-HT Receptor	Cardiovascular Disease
BMY 7378 is a selective antagonist of α_1D-adrenoceptor (α_1D-AR). BMY 7378 binds to membranes expressing the cloned rat α_1D-AR with a >100-fold higher affinity (K_i=2 nM) than binding to either the cloned rat α_1A-AR (K_i=800 nM) or the hamster α_1B-AR (K_i=600 nM). BMY 7378 is a 5-HT_1A receptor partial agonist .

HY-P2469

Brain Natriuretic Peptide-45, mouse BNP-45, mouse	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Brain Natriuretic Peptide-45, mouse (BNP-45, mouse) is a 45-amino-acid peptide derived from the mouse BNP prohormone, which exhibits natriuretic, diuretic, and vasoactive effects. Brain Natriuretic Peptide-45, mouse contains all amino acid residues deemed critical for the biological activity of natriuretic peptides. Brain Natriuretic Peptide-45, mouse possesses hypotensive and diuretic activities .

HY-123068

Captopril disulfide SQ 14551	Drug Derivative	Cardiovascular Disease
Captopril disulfide (SQ 14551) is an orally active disulfide dimer prodrug. Captopril disulfide is metabolized to Captopril and acts as a Bradykinin potentiator. Captopril disulfide enhances the vasodilatory effect of Bradykinin in anesthetized rats and the contractile response of isolated guinea pig ileum to Bradykinin. Captopril disulfide exhibits antihypertensive activity in spontaneously hypertensive rats. Captopril disulfide can be used in hypertension-related research .

HY-107398

1-(2,3-Dichlorophenyl)ethanamine hydrochloride	Adrenergic Receptor Amine N-methyltransferase	Cardiovascular Disease
1-(2,3-Dichlorophenyl)ethanamine hydrochloride is a phenylethanolamine N-methyltransferase (PNMT) inhibitor. 1-(2,3-Dichlorophenyl)ethanamine hydrochloride effectively reduces blood pressure of spontaneously hypertensive. 1-(2,3-Dichlorophenyl)ethanamine hydrochloride can be used for the research of blood pressure .

HY-111827

S-1-Propenyl-L-cysteine 5+ Cited Publications	Histamine Receptor	Cardiovascular Disease Others Metabolic Disease Inflammation/Immunology
S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model . S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway . S-1-Propenyl-L-cysteine is orally active.

HY-E70199

Aminopeptidase N (rat) APN/CD13	Aminopeptidase	Cardiovascular Disease
Aminopeptidase N (rat) (APN/CD13) is a Zn ²⁺-dependent membrane-bound exopeptidase that preferentially degrades proteins and peptides with N-terminal neutral amino acids. Aminopeptidase N (rat) is inhibited by angiotensin IV and participates in the regulation of angiotensin IV half-life in the rat striatum .

HY-106103

Seglitide MK-678; L-363586	Somatostatin Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Seglitide (MK-678) is an orally active, selective SSTR2 agonist and somatostatin analog. Seglitide also acts as a competitive Somatostatin receptor antagonist, with pA2 values of 6.50, 6.24 and 6.09 against SS₁₄, SS₂₅ and SS₂₈, respectively. Seglitide produces only weak, transient inhibition of myocardial contractility in isolated right atria of guinea pigs. Seglitide inhibits glucagon secretion and reduces circulating insulin levels. Seglitide causes a sustained, reversible reduction in elevated systolic blood pressure in streptozotocin (HY-13753)-induced diabetic rats, but exerts no effect on spontaneously hypertensive rats. Seglitide induces membrane hyperpolarization and inhibits electrical excitability. Seglitide induces concentration-dependent contraction and significant desensitization in isolated distal colon of rats. Seglitide can be used in research related to hypertension complicated with insulin-dependent diabetes mellitus .

HY-W013989

1,3-Dicyclohexylurea	Epoxide Hydrolase	Cardiovascular Disease
1,3-Dicyclohexylurea (DCU) is an orally active and potent sEH (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats .

HY-19664

Pranidipine OPC-13340	Calcium Channel NO Synthase	Cardiovascular Disease
Pranidipine (OPC-13340) is an orally active L-type voltage-dependent calcium channel (L-VDCC) blocker with a K_i value of 0.16 nM. Pranidipine inhibits calcium-induced contraction, suppresses slow-response action potentials, shortens action potential duration, reduces systolic and diastolic blood pressure, and exerts vasodilatory effects. Pranidipine enhances its vasodilatory effect by blocking NO decomposition. Pranidipine can be used in research related to essential hypertension, angina pectoris, myocardial infarction, and dilated cardiomyopathy .

HY-18006

NKP608 1 Publications Verification	Neurokinin Receptor Wnt Bcl-2 Family β-catenin Cyclin G-associated Kinase (GAK) VEGFR Caspase Cadherin Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
NKP608 is a non-peptidic derivative of 4-aminopiperidine, a highly selective, orally active, neurokinin-1 (NK₁) receptor antagonist with IC₅₀ of 2.6 nM. NKP608 is active both in vitro and in vivo, showing extremely low affinity for NK₂, NK₃ receptors. NKP608 exerts its effects by blocking the NK₁ receptor, regulate cell proliferation and apoptosis, affect neurotransmitter functions and gastric mucosal repair mechanisms, and suppress the Wnt/β-catenin pathway in antitumor research. NKP608 is applicable to research related to various diseases, including cough, anxiety disorders, depression, gastric mucosal injury, and colorectal cancer .

HY-W012814R

4-Methylcatechol (Standard)	Reference Standards Endogenous Metabolite Apoptosis Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Cancer
4-Methylcatechol (Standard) is the analytical standard of 4-Methylcatechol. This product is intended for research and analytical applications. 4-Methylcatechol is an intermediate in the degradation of some alkylbenzenes and an orally active suicide inhibitor of catechol 2,3-dioxygenase (C23O). 4-Methylcatechol induces apoptosis in melanoma cells through oxidative stress, but some studies have also shown that 4-Methylcatechol is carcinogenic. In addition, 4-Methylcatechol has antiplatelet and blood pressure-lowering activities. 4-Methylcatechol can also inhibit protein oxidation in beef but does not disulfide formation[1][2][3][4][5][6].

HY-153369

BAY-747 BAY 1165747	Guanylate Cyclase	Cardiovascular Disease Neurological Disease
BAY-747 (BAY 1165747) is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model .

HY-116680

LY53857	5-HT Receptor	Cardiovascular Disease Neurological Disease
LY53857 is a potent antagonist of vasoconstriction and serotonin-mediated 5-HT₂ receptors. LY53857 did not reduce mean arterial blood pressure in spontaneously hypertensive rats (SHR) at doses that blocked the depressor response to serotonin and blocked central serotonin receptors. In addition, LY53857 was able to enhance neurotransmitter release in rat vas deferens and guinea pig ileal nerves .

HY-101390D

(R)-Niguldipine	Calcium Channel	Cardiovascular Disease
(R)-Niguldipine, a R-epimer of Niguldipine (HY-101390B), is a calcium channel antagonist. (R)-Niguldipine exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (R)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID₅₀ of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (K_i of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED₃₀ of 5.55). (R)-Niguldipine can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias .

HY-127152

Hippadine Pratorine	Endogenous Metabolite	Cardiovascular Disease
Hippadine (Pratorine) is an alkaloid, which can be isolated from the plant Crinum macowanii. Hippadine exhibits heart-rate lowering and blood-pressure lowering effects in rats models with spontaneously hypertensive .

HY-19291

DL-017	Adrenergic Receptor Sodium Channel	Cardiovascular Disease
DL-017 is a Quinazoline derivative. DL-017 shows inhibitory constants of approximately 0.90 nM for α1-adrenergic receptors and 404 nM for Na ⁺ channels. DL-017 exerts antihypertensive effect .

HY-N4209

3α-Dihydrocadambine	Others	Cardiovascular Disease
3α-Dihydrocadambine is a natural product isolated from the heartwoods of Anthocephalus cadamba.3α-Dihydrocadambine exhibits dose-dependent hypotensive and anti-hypertensive effects in anesthetized normotensive rats and in conscious spontaneously hypertensive rats .

HY-19253A

KRH-594	Angiotensin Receptor	Cardiovascular Disease Metabolic Disease
KRH-594 is an orally active angiotensin AT1 receptor antagonist. KRH-594 ameliorates the progression of diabetic nephropathy and hyperlipidaemia. KRH-594 inhibits cardiac hypertrophy .

HY-19070

BRL-52656	Opioid Receptor	Cardiovascular Disease
BRL-52656 is a blood-brain barrier (BBB)-penetrable KOR receptor agonist that exhibits a biphasic effect. At low doses, BRL-52656 decreases blood pressure, whereas high doses have the opposite effect in spontaneously hypertensive rats. Additionally, BRL-52656 induces water diuresis by inhibiting the secretion of vasopressin (AVP) .

HY-W752502

Docarpamine	Dopamine Receptor Vasopressin Receptor Adrenergic Receptor	Cardiovascular Disease
Docarpamine is an orally active dopamine prodrug that can be hydroxylated in the small intestine and liver to form active dopamine. Docarpamine mainly activates D1-like receptors in peripheral blood vessels to lower blood pressure and heart rate in a state of spontaneous hypertension. Docarpamine exerts a pressor and tachycardic effect by activating D1-like receptors, vasopressin V1 receptors, and α-adrenergic receptors in normal blood pressure conditions. Docarpamine can be used for research on renal vascular dilation and diuresis .

HY-116262

SCH 51866	Phosphodiesterase (PDE)	Cardiovascular Disease Inflammation/Immunology
SCH 51866 is a potent, selective and orally active inhibitor of PDE1 (IC₅₀=70 nM) and PDE5 (IC₅₀=60 nM). SCH 51866 inhibits collagen-induced aggregation of human washed platelets (IC₅₀=10 μM), prevents neointimal formation in balloon catheter-injured carotid arteries of spontaneously hypertensive rats (SHR), and reduces blood pressure in SHR. SCH 51866 can be used in the study of hypertension .

HY-19200

RB-105	Neprilysin Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
RB-105 is an inhibitor of angiotensin-converting enzyme (ACE) (K_i = 4.2 nM) and neutral endopeptidase (NEP) (K_i = 1.7 nM). RB-105 after inhibiting ACE reduces the production of Ang II and increase the level of bradykinin. RB-105 after inhibiting NEP increases the level of natriuretic peptide and further increases the level of bradykinin, thereby generating a powerful synergistic effect. RB-105 has significant antihypertensive and natriuretic effects in both spontaneously hypertensive rats and normal blood pressure rats. RB-105 can be used for research on hypertension .

HY-101390A

(-)-Niguldipine hydrochloride (R)-Niguldipine hydrochloride	Calcium Channel	Cardiovascular Disease
(-)-Niguldipine ((R)-Niguldipine) hydrochloride is a calcium channel antagonist. (-)-Niguldipine hydrochloride exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (-)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID₅₀ of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (K_i of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED₃₀ of 5.55). (-)-Niguldipine hydrochloride can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias .

HY-19053

NP-252	Calcium Channel	Cardiovascular Disease
NP-252 is a calcium channel antagonist with an 20% effective dose (ED20) of 2.55 mg/kg in spontaneously hypertensive rats .

HY-155042

Antihypertensive agent 3	Angiotensin Receptor	Cardiovascular Disease
Antihypertensive agent 3 (compound 4a) is an antagonis of angiotensin II receptor 1. Antihypertensive agent 3 exhibits antihypertensive activity in a spontaneously hypertensive rats (SHRs) model .

HY-129706

LY127210 free base	Others	Cardiovascular Disease
LY127210 (free base) is a potent vasodilator with antihypertensive effects that reduces pressure in chloralose-anesthetized spontaneously hypertensive rats primarily by direct arteriolar dilation and to a lesser extent by decreasing cardiac output. LY127210 (free base) reduces blood pressure, heart rate and left ventricular end-diastolic pressure in hypertensive rats by reducing vascular resistance .

HY-136880

Flufylline Sgd 195/78	5-HT Receptor	Cardiovascular Disease
Flufylline shows antihypertensive properties in spontaneously hypertensive rats and display antagonism towards 5-HT receptors in various animal models. Flufylline can be used for cardiovascular disease research .

HY-121550

ME3221	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
ME3221 is an angiotensin AT1 receptor antagonist that effectively antagonizes the pressor response to angiotensin II in rats and marmosets without affecting the hypotensive response to bradykinin. It demonstrates potent antihypertensive effects in renal hypertensive rats and spontaneously hypertensive rats (SHR). ME3221's repeated administration in SHR results in sustained and stable hypotensive effects without affecting heart rate, indicating its potential for studying both renal and essential hypertension .

HY-P4296

H-Gly-Sar-Sar-OH	Amino Acid Derivatives	Others
H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation .

HY-105527

Flavodilol	Adrenergic Receptor	Cardiovascular Disease
Flavodilol is an orally active antihypertensive agent. Flavodilol extensively depletes catecholamines and serotonin in heart tissue of normotensive and spontaneously hypertensive rats (SHR). Flavodilol can be used for hypertension research .

HY-A0117

Temocaprilat Temocapril diacid; Temocaprilate; RS 5139	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Temocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE). Temocaprilat alleviates the inhibitory effect of high glucose on the proliferation of aortic endothelial cells. Temocaprilat has potential applications in hypertension and vascular inflammation .

HY-103247B

EMD-66684 potassium salt	Angiotensin Receptor	Cardiovascular Disease
EMD-66684 potassium salt is a non-peptide angiotensin II receptor antagonist that demonstrates significant antihypertensive effects in spontaneously hypertensive rats. EMD-66684 potassium salt exhibits nanomolar affinity for angiotensin II receptors, comparable to losartan in potency. EMD-66684 potassium salt shows increased activity when modified with acetamides, leading to superior blood pressure reduction.

HY-19078

SQ-30741	Prostaglandin Receptor	Cardiovascular Disease
SQ-30741 is a thromboxane A2 receptor antagonist. SQ-30741 reduces vasoconstriction in a feline pulmonary vascular bed model. SQ-30741 increases relaxation of aortic endothelium and vascular smooth muscle in adult rats in a spontaneously hypertensive rat model. SQ-30741 can be used in research on cardiovascular diseases such as hypertension .

HY-106720

Amosulalol YM 09538	Adrenergic Receptor	Cardiovascular Disease
Amosulalol (YM 09538) is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR) .

HY-106720A

Amosulalol hydrochloride YM 09538 hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Amosulalol (YM 09538) hydrochloride is an orally active and dual inhibitor of α1/β1-Adrenergic Receptor. Amosulalol hydrochloride exhibits antihypertensive activity via α1-Adrenergic Receptor inhibition. Amosulalol hydrochloride decreases reflexogenic increases in heart rate and plasma renin activity (PRA) via β1-Adrenergic Receptor inhibition in spontaneously hypertensive rats (SHR) .

HY-106720C

(+)-Amosulalol (+)-YM 09538	Adrenergic Receptor	Others
(+)-Amosulalol ((+)-YM 09538) is an isomer of Amosulalol (HY-106720), an orally active dual inhibitor of α1/β1-adrenergic receptors. Amosulalol exhibits antihypertensive activity by inhibiting α1-adrenergic receptors. Amosulalol reduces the reflex increase in heart rate and plasma renin activity (PRA) in spontaneously hypertensive rats (SHR) by inhibiting β1-adrenergic receptors.

HY-106720B

(-)-Amosulalol (-)-YM 09538	Adrenergic Receptor	Others
(-)-Amosulalol ((-)-YM 09538) is an isomer of Amosulalol (HY-106720), an orally active dual inhibitor of α1/β1-adrenergic receptors. Amosulalol exhibits antihypertensive activity by inhibiting α1-adrenergic receptors. Amosulalol reduces the reflex increase in heart rate and plasma renin activity (PRA) in spontaneously hypertensive rats (SHR) by inhibiting β1-adrenergic receptors.

HY-111827R

S-1-Propenyl-L-cysteine (Standard)	Histamine Receptor	Cardiovascular Disease Others Metabolic Disease Inflammation/Immunology
S-1-Propenyl-L-cysteine (Standard) is the analytical standard of S-1-Propenyl-L-cysteine. This product is intended for research and analytical applications. S-1-Propenyl-L-cysteine is a stereoisomer of S-allyl-l-cysteine, extracted from garlic, with immunomodulatory effects and reduces blood pressure in a hypertensive animal model . S-1-Propenyl-L-cysteine exhibits antioxidative efficacy through a NO-dependent BACH1 signaling pathway . S-1-Propenyl-L-cysteine is orally active.

HY-171469

SKP-451	Potassium Channel	Cardiovascular Disease
SKP-451 is an ATP-sensitive potassium (K ⁺) channel agonist. SKP-451 activates the ATP-sensitive K ⁺ channels, promotes the efflux of K ⁺, causes membrane hyperpolarization, and inhibits the influx of Ca ²⁺, thereby relaxing the vascular smooth muscle. SKP-451 relaxs the canine coronary artery, rabbit basilar artery, and vertebral artery. SKP-451 also reduces the mean arterial blood pressure of conscious spontaneously hypertensive rats (SHR). SKP-451 is promising for research of cardiovascular diseases .

HY-123449A

MK-761 TFA	Adrenergic Receptor	Cardiovascular Disease Neurological Disease
MK-761 TFA is an orally effective β2-adrenergic receptor antagonist. MK-761 TFA attenuates positive inotropic effects, reduces arterial pressure, enhances the contractility of papillary muscles in cat hearts, and exerts effects mediated by catecholamine release. MK-761 TFA can be used in the research of hypertension .

HY-123449

MK-761 free base	Adrenergic Receptor	Cardiovascular Disease
MK-761 free base is an orally effective β2-adrenergic receptor antagonist. MK-761 free base attenuates positive inotropic effects, reduces arterial pressure, enhances the contractility of papillary muscles in cat hearts, and exerts effects mediated by catecholamine release. MK-761 free base can be used in the research of hypertension .

HY-129599

L-2286	PARP NF-κB	Cardiovascular Disease Neurological Disease
L-2286 is an orally active PARP-1 inhibitor. L-2286 alleviates carotid artery remodeling, oxidative stress and inflammation in spontaneously hypertensive rats, protects neurons in the dorsal hippocampus, and reduces pyramidal cell loss and gliosis without affecting blood pressure. L-2286 can be used in research related to hypertension .

HY-103247

EMD 66684	Angiotensin Receptor	Cardiovascular Disease
EMD 66684 is an antagonist of Angiotensin II Type 1 (AT1) receptor. EMD 66684 shows potent binding affinities for the AT1 subtype Ang II receptor with an IC₅₀ value of 0.7 nM. EMD 66684 also serves as an antiischemic cytoprotectant ^- .

Art. -Nr.	Produktname	Target	Research Area

HY-118060

Dipeptide 2 N-Valyltryptophan; Val-Trp	Angiotensin-converting Enzyme (ACE) Calcium Channel NO Synthase	Cardiovascular Disease
Dipeptide 2 (N-Valyltryptophan) is an orally active, competitive angiotensin-converting enzyme (ACE) inhibitory peptide with an IC₅₀ of 10.50 μM. Dipeptide 2 reduces intracellular Calcium ions. Dipeptide 2 significantly increases the content of NO, inhibits the production of ET-1, and induces the phosphorylation of eNOS. Dipeptide 2 decreases the systolic and diastolic blood pressure of spontaneously hypertensive rats .

HY-P2469

Brain Natriuretic Peptide-45, mouse BNP-45, mouse	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Brain Natriuretic Peptide-45, mouse (BNP-45, mouse) is a 45-amino-acid peptide derived from the mouse BNP prohormone, which exhibits natriuretic, diuretic, and vasoactive effects. Brain Natriuretic Peptide-45, mouse contains all amino acid residues deemed critical for the biological activity of natriuretic peptides. Brain Natriuretic Peptide-45, mouse possesses hypotensive and diuretic activities .

HY-106103

Seglitide MK-678; L-363586	Somatostatin Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Seglitide (MK-678) is an orally active, selective SSTR2 agonist and somatostatin analog. Seglitide also acts as a competitive Somatostatin receptor antagonist, with pA2 values of 6.50, 6.24 and 6.09 against SS₁₄, SS₂₅ and SS₂₈, respectively. Seglitide produces only weak, transient inhibition of myocardial contractility in isolated right atria of guinea pigs. Seglitide inhibits glucagon secretion and reduces circulating insulin levels. Seglitide causes a sustained, reversible reduction in elevated systolic blood pressure in streptozotocin (HY-13753)-induced diabetic rats, but exerts no effect on spontaneously hypertensive rats. Seglitide induces membrane hyperpolarization and inhibits electrical excitability. Seglitide induces concentration-dependent contraction and significant desensitization in isolated distal colon of rats. Seglitide can be used in research related to hypertension complicated with insulin-dependent diabetes mellitus .

HY-P4296

H-Gly-Sar-Sar-OH	Amino Acid Derivatives	Others
H-Gly-Sar-Sar-OH is an orally active tripeptide. H-Gly-Sar-Sar-OH is transported through PepT1 within Caco-2 cells. H-Gly Sar Sar OH has potential applications in material transportation .

HY-P11411

[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat	Neuropeptide Y Receptor Histamine Receptor	Cardiovascular Disease
[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat is a fragment analogue of a neuropeptide Y (NPY) with cardiovascular activity. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can induce profound and sustained hypotension in both hypertensive and normotensive rats and its antihypertensive effect is partly attributed to its activity on histamine receptor. [D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat can be used for studying antihypertensive effects .

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