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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
thapsigargin
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "thapsigargin" in MCE Product Catalog:
158
158 Cited Publications
Category:
Infection Umbelliferae Extract Terpenoids Diterpenoids Plants Disease Research Fields Cancer Thapsia garganica L.
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ATF4-IN-2 is an ATF4 inhibitor with an IC50 of 47.71 nM. ATF4-IN-2 activates eIF2B, binds to the ISRIB (HY-12495A) binding pocket, restores protein translation, and inhibits ATF4 expression. ATF4-IN-2 inhibits ATF4 protein expression in Thapsigargin (HY-13433)-stimulated cells. ATF4-IN-2 can be used for research on neurodegenerative diseases .
Cat. No.: HY-D1608
CAS No.: 216571-99-2
Cat. No.: HY-13433R
CAS No.: 67526-95-8
Cat. No.: HY-159494
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PROTAC sEH degrader-1 is a PROTAC degrader targeting soluble epoxide hydrolase (sEH) with a DC50 of 0.5 nM, and it also possesses sEH inhibitory activity. PROTAC sEH degrader-1 has an IC50 of 3.8 nM against human sEH and an IC50 of 210 nM against mouse sEH. PROTAC sEH degrader-1 relies on the ubiquitin-proteasome system to achieve target protein degradation, and it selectively degrades cytoplasmic sEH. PROTAC sEH degrader-1 rapidly reduces endoplasmic reticulum stress in cells, downregulates the phosphorylation levels of IRE1α, PERK and eIF2α, enhances cell viability, and alleviates Thapsigargin (HY-13433)-induced apoptosis. PROTAC sEH degrader-1 effectively degrades sEH in mouse liver and brown adipose tissue. PROTAC sEH degrader-1 can be used in studies related to metabolic disorders and inflammation .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
