3 Results for "

transdifferentiation

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "transdifferentiation" in MCE Product Catalog:

19-Hydroxyandrost-4-ene-3,17-dione
19-Hydroxyandrost-4-ene-3,17-dione
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Cat. No.: HY-113302
CAS No.: 510-64-5
Purity:  99.11%
Category:  

Other Diseases Endogenous metabolite Disease Research Fields Steroids

Target:  

Endogenous Metabolite Apoptosis

19-Hydroxyandrost-4-ene-3,17-dione is an endogenous adrenal C19 steroid and also an agonist of the olfactory receptor OR51E2, with an EC50 of 0.15 nM. 19-Hydroxyandrost-4-ene-3,17-dione activates G protein-coupled receptor signaling pathways, drives neuroendocrine transdifferentiation, induces G0/G1 cell cycle arrest, reduces apoptosis and anabolic signaling, decreases cell viability, and reprograms cell metabolic profiles. 19-Hydroxyandrost-4-ene-3,17-dione induces sodium retention and hypertension, and its secretion is regulated by ACTH and the renin-angiotensin system. 19-Hydroxyandrost-4-ene-3,17-dione can be used in research related to prostate cancer, metastatic breast cancer, and hypertension .
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LY3056480
LY3056480
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Cat. No.: HY-158012
CAS No.: 2064292-78-8
Target:  

γ-secretase Notch

Research Areas:  

Neurological Disease

LY3056480 is a γ-secretase inhibitor. LY3056480 inhibits the Notch signaling pathway, upregulates Atoh1, promotes hair cell regeneration, and drives supporting cell transdifferentiation. LY3056480 is applicable to research related to sensorineural hearing loss .
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Mogroside III-E
Mogroside III-E
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Cat. No.: HY-N6928
CAS No.: 88901-37-5
Category:  

Triterpenes Terpenoids Metabolic Disease Cucurbitaceae Extract Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields

Target:  

Toll-like Receptor (TLR) ERK JNK p38 MAPK TGF-β Receptor TGF-beta/Smad Interleukin Related

Mogroside III-E is a cucurbitane-type triterpenoid glycoside extracted from Siraitia grosvenorii, and it is an orally active TLR4 inhibitor. Mogroside III-E downregulates the expression of TLR4 and MyD88, and blocks the phosphorylation of downstream ERK, JNK and p38 MAPK molecules; meanwhile, it inhibits TGF-β- or LPS-mediated transdifferentiation of primary pulmonary fibroblasts into myofibroblasts, reduces the content of fibrosis markers such as hydroxyproline, suppresses the pro-fibrotic TGF-β/Smad signaling pathway, and downregulates the levels of inflammatory factors MPO and IL-1β. Mogroside III-E alleviates Bleomycin (HY-108345)-induced pulmonary collagen deposition and inflammatory infiltration in mice. Mogroside III-E can be used in studies related to idiopathic pulmonary fibrosis .
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