29 Results for "

vascular adhesion molecule-1

" in MedChemExpress (MCE) Product Catalog:
Products (29)

29 Results for "vascular adhesion molecule-1" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-N1990
CAS No.: 94987-08-3
Gypenoside XLIX is a multifunctional bioactive compound that can be isolated from Gynostemma pentaphyllum, with a Ka value of 1.58 μM for its binding to SIRT1. Gypenoside XLIX acts as a PPAR-α agonist. It inhibits the activation of TLR4-mediated NF-κB signaling pathway by activating the Sirt1/Nrf2 signaling pathway, reduces ROS accumulation, and alleviates hepatic inflammatory injury in mice with sepsis-induced liver disease. Gypenoside XLIX targets SIRT1 to block YAP-NLRP3 activation and improve sepsis-induced cardiomyopathy. Gypenoside XLIX inhibits apoptosis (Apoptosis), pyroptosis (Pyroptosis), autophagy (Autophagy), lipid peroxidation, pro-inflammatory cytokines and anti-inflammatory cytokines. Gypenoside XLIX alleviates sepsis-induced splenic injury by inhibiting inflammation and oxidative stress, and mitigates sepsis-associated encephalopathy by targeting PPAR-α. Gypenoside XLIX prevents acute kidney injury by inhibiting IGFBP7/IGF1R-mediated programmed cell death and inflammation. Gypenoside XLIX inhibits the expression and activity of vascular cell adhesion molecule-1 in cytokine-induced human endothelial cells. Gypenoside XLIX is applicable to research related to acute liver injury, lung injury, cardiomyopathy, acute splenic injury, sepsis-associated encephalopathy, acute kidney injury, atherosclerosis and chronic inflammation .
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2
2 Cited Publications
Cat. No.: HY-125864B
CAS No.: 9001-32-5
Target:  

MMP Cadherin

Murine Fibrinogen is a native fibrinogen derived from mouse plasma. Murine Fibrinogen acts as a cerebrovascular permeability enhancer. Murine Fibrinogen activates matrix metalloproteinase-9 (MMP-9), downregulates the expression of vascular endothelial cadherin (VE-cadherin), and upregulates the expression of plasmalemmal vesicle-associated protein-1 (PV-1). Murine Fibrinogen increases macromolecular leakage from pial veins, thereby disrupting the microvascular integrity of cerebral blood vessels. Murine Fibrinogen can be used in studies related to cerebrovascular dysfunction .
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Cat. No.: HY-NP203
Synonyms: HDL (human)
High density lipoprotein (human) (HDL (human)) is a human-derived high-density lipoprotein. High density lipoprotein can cross the blood-brain barrier, and partially acts on endothelial nitric oxide synthase (eNOS) by activating surface receptors such as SR-B1 and S1P3R, as well as intracellular signaling cascades involving Akt, PI3K and MAPK, thereby inducing the production of NO in endothelial cells. High density lipoprotein (human) can be used in research related to type 2 diabetes, Alzheimer's disease, cancer and atherosclerosis .
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Cat. No.: HY-N2110
CAS No.: 2543-94-4
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .
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Cat. No.: HY-N2110R
CAS No.: 2543-94-4
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.
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Cat. No.: HY-127113
CAS No.: 1541762-55-3
Target:  

Leukotriene Receptor

Research Areas:  

Cardiovascular Disease

Q8, an effective antiangiogenic drug, is a CysLt1 antagonist (IC50 of 4.9 μM). Q8 is sufficient to reduce cellular levels of NF-κB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1, vascular cell adhesion protein-1, and VEGF .
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Cat. No.: HY-N1990R
CAS No.: 94987-08-3
Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .
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Cat. No.: HY-W027751R
CAS No.: 578-58-5
Research Areas:  

Others

Gypenoside XLIX (Standard) is the analytical standard of Gypenoside XLIX. This product is intended for research and analytical applications. Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells .
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Cat. No.: HY-119142
CAS No.: 379692-00-9
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

CP-664511 is an orally active and potent α4β1 integrin antagonist with anti-inflammatory effects (IC50=0.52 nM). CP-664511 inhibits the interaction between α4β1 and vascular cell adhesion molecule-1 (VCAM-1), significantly reducing eosinophil infiltration into lung tissue. CP-664511 is promising for research of asthma and allergic airway diseases .
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Cat. No.: HY-P70852
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin Cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin Cell adhesion molecule 1; Mucosal Addressin Cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P77748
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin Cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin Cell adhesion molecule 1; Mucosal Addressin Cell adhesion molecule-1; MACAM1
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P704773
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin Cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin Cell adhesion molecule 1; Mucosal Addressin Cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P71818
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin Cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin Cell adhesion molecule 1; Mucosal Addressin Cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
P. pastoris
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Cat. No.: HY-P72397
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin Cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin Cell adhesion molecule 1; Mucosal Addressin Cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P704774
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin Cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin Cell adhesion molecule 1; Mucosal Addressin Cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P705058
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin Cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin Cell adhesion molecule 1; Mucosal Addressin Cell adhesion molecule-1; MACAM1
Species:  
Human
Source:  
HEK293
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Cat. No.: HY-P705198
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin Cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin Cell adhesion molecule 1; Mucosal Addressin Cell adhesion molecule-1; MACAM1
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P705263
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MADCAM1; HMAdCAM-1; Mucosal vascular Addressin Cell adhesion molecule 1; MAdCAM-1; Mucosal Addressin Cell adhesion molecule 1; Mucosal Addressin Cell adhesion molecule-1; MACAM1
Species:  
Mouse
Source:  
HEK293
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Cat. No.: HY-P704202
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VCAM1; vascular Cell adhesion molecule 1; vascular Cell adhesion Protein 1; CD106; CD106 Antigen; INCAM-100; V-CAM 1; VCAM-1
Species:  
Cynomolgus
Source:  
HEK293
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Cat. No.: HY-P7777
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: VCAM1; vascular Cell adhesion molecule 1; vascular Cell adhesion Protein 1; CD106; CD106 Antigen; INCAM-100; V-CAM 1; VCAM-1
Species:  
Human
Source:  
HEK293
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