Secoisolariciresinol dimethyl ether diacetate
Secoisolariciresinol dimethyl ether diacetate is a dibenzylbutane lignan that can be found in Justicia procumbens L. It is a component of the ethyl acetate extract of Justicia procumbens L. and can be detected in rat plasma after oral administration of this extract. Secoisolariciresinol dimethyl ether diacetate can be used in studies of lignans, natural products, and plasma pharmaceutical chemistry.
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- CAS No.: 119030-75-0
- Formula: C26H34O8
- Molecular Weight:474.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
In Vitro
Secoisolariciresinol dimethyl ether diacetate (compound 4) is prepared by acetylation of the corresponding secoisolariciresinol dimethyl ether, and its physical and spectroscopic properties are identical to those of an authentic sample[1].
Secoisolariciresinol dimethyl ether diacetate (compound 3) is isolated from the aerial parts of Justicia procumbens (12.7 mg), and its structure is determined by HREIMS, 1H NMR, and 13C NMR. This study reports it as the first natural isolation of this compound[2].
Secoisolariciresinol dimethyl ether diacetate (10 mg; 5 mL 1% NaOH in MeOH; room temperature overnight) undergoes saponification to yield secoisolariciresinol dimethyl ether (compound 8)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 119030-75-0
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Molecular Weight 474.55
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Formula C26H34O8
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SMILES
[C@H]([C@@H](CC1=CC(OC)=C(OC)C=C1)COC(C)=O)(CC2=CC(OC)=C(OC)C=C2)COC(C)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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How to Select the Route of Administration for Mammals
Route-of-administration selection in mammals is a pharmacokinetic, pharmacodynamic, formulation, animal-welfare, and translational decision, not a default technical choice. The selected route should match the study goal: intravenous dosing is most useful when complete systemic exposure and rapid onset are required, oral dosing is most translational for orally intended medicines but is affected by absorption and first-pass metabolism, subcutaneous or intramuscular dosing can provide slower systemic exposure, and intraperitoneal dosing can be useful in rodent proof-of-concept studies but may have limited clinical translation. Published route-comparison studies show that the same compound can produce different exposure, onset, bioavailability, tissue distribution, and tolerability depending on route; therefore, route choice should be supported by pilot pharmacokinetic or pharmacodynamic evidence when the literature is insufficient. Unresolved questions include how to standardize route sel
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Secoisolariciresinol dimethyl ether diacetate Related Classifications
HY-N21688 Related Classifications
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