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Cat. No.: HY-165425

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KR31173

KR31173 is an AT1 antagonist with an IC₅₀ of 3.27  nM. KR31173 can be used as a positron emission tomography (PET) tracer after being labeled with 11C isotope. KR31173 shows promising biodistribution and pharmacological properties in mice. KR31173 selectively binds to organs known to contain a high density of AT1 angiotensin receptors in CD-1 mice.

For research use only. We do not sell to patients.

CAS No.: 260554-07-2
Formula: C₃₁H₃₀N₈O₂
Molecular Weight:546.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

KR31173 Chemical Structure

CAS No.: 260554-07-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

AT1 Receptor

3.27 nM (IC₅₀)

All Angiotensin Receptor Isoforms :

In Vivo

[¹¹C] KR31173 (19.1 MBq (517 μCi, 1.45 μg/kg), i.v., 5-90 min) selectively binds to organs known to contain a high density of AT1 angiotensin receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male CD-1 mice were injected via the tail vein with 19.1 MBq (517 μCi, 1.45 μg/kg) of [¹¹C] KR31173 10 min after KR31173 administration^[1].
Dosage:

1 mg/kg
Administration:

i.v., once and then collected blood sample, and measured organs weight and their radioactivity 60 min after [¹¹C] KR31173 administration.
Result:

Had high initial liver uptake which rapidly washes out over 30 minutes following by subsequent accumulation in adrenal glands and kidneys after 30 minutes, with tissue-to-blood ratios generally exceeding 10:1.
Significantly inhibited the uptake of [¹¹C] KR31173 in the adrenal glands (91%), kidneys (90%), lungs (88%), heart (92%) and livers (50%).

Chemical Information

CAS No. 260554-07-2
Molecular Weight 546.62
Formula C₃₁H₃₀N₈O₂
SMILES

[O-][N+]1=CC=CC=C1C2=C(COC)N=C(N(CC3=CC=C(C4=CC=CC=C4C5=NN=NN5)C=C3)C(CCCC)=N6)C6=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mathews WB, et al. A novel radioligand for imaging the AT1 angiotensin receptor with PET. Nucl Med Biol. 2004 Jul; 31(5):571-4. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

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KR31173

All Angiotensin Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

KR31173 Related Classifications

HY-165425 Related Classifications