T5996207
T5996207 is a MyD88 inhibitor. T5996207 inhibits LPS-induced MyD88-mediated NF-κB-driven SEAP expression. T5996207 protects mice from lethal staphylococcal enterotoxin B-induced shock. T5996207 can be used for research on acute lung injury and toxic shock.
For research use only. We do not sell to patients.
- CAS No.: 950003-29-9
- Formula: C20H28N4O3S2
- Molecular Weight:436.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 950003-29-9
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Molecular Weight 436.59
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Formula C20H28N4O3S2
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SMILES
O=C(NCC=1SC(=CC1)S(=O)(=O)N(CC)CC)N2CCN(C=3C=CC=CC3)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhu L, et al. Design, Synthesis, and Biological Evaluation of a MyD88-Targeted Molecular Glue d21 for the Treatment of Acute Lung Injury. Journal of medicinal chemistry. 2026 Jun 25;69(12):14722-14740. [Content Brief]
[2]. Olson MA, et al. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Scientific reports. 2015 Sep 18;5:14246. [Content Brief]
[3]. Chen P. Discovery of 3g as an Orally Bioavailable, TIR Domain Selective, and Potent MyD88 Inhibitor for the Treatment of Acute Lung Injury. Journal of Medicinal Chemistry. 2025 Sep 12;68(18):19626-44. [Content Brief]
[4]. Chen L. Myeloid differentiation primary response protein 88 (MyD88): the central hub of TLR/IL-1R signaling. Journal of medicinal chemistry. 2020 Sep 15;63(22):13316-29. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T5996207 Related Classifications
HY-125480 Related Classifications
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