country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-131443

Copy Link Print Information

TRC-766

Name: TRC-766
Brand: MedChemExpress
SKU: HY-131443
Price: 220.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: DBK-766)

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase.

For research use only. We do not sell to patients.

Purity : 98.07%
CAS No.: 1810734-44-1
Formula: C₂₅H₂₄ClF₃N₂O₃S
Molecular Weight:524.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TRC-766 Chemical Structure

CAS No.: 1810734-44-1

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase^[1].

In Vitro

As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1810734-44-1
Appearance Solid
Molecular Weight 524.98
Formula C₂₅H₂₄ClF₃N₂O₃S
Color White to off-white
SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(N(CCCN2C3=CC(Cl)=CC=C3CCC4=CC=CC=C42)C)=O
Synonyms

DBK-766
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

All

Sort by:

Journal Impact Factor

University of Michigan

2026.

Solvent & Solubility

In Vitro:

DMSO : 150 mg/mL (285.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9048 mL

9.5242 mL

19.0483 mL

5 mM

0.3810 mL

1.9048 mL

3.8097 mL

10 mM

0.1905 mL

0.9524 mL

1.9048 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kimberly McClinch, et al. Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer. Cancer Res. 2018 Apr 15;78(8):2065-2080. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9048 mL	9.5242 mL	19.0483 mL	47.6209 mL
	5 mM	0.3810 mL	1.9048 mL	3.8097 mL	9.5242 mL
	10 mM	0.1905 mL	0.9524 mL	1.9048 mL	4.7621 mL
	15 mM	0.1270 mL	0.6349 mL	1.2699 mL	3.1747 mL
	20 mM	0.0952 mL	0.4762 mL	0.9524 mL	2.3810 mL
	25 mM	0.0762 mL	0.3810 mL	0.7619 mL	1.9048 mL
	30 mM	0.0635 mL	0.3175 mL	0.6349 mL	1.5874 mL
	40 mM	0.0476 mL	0.2381 mL	0.4762 mL	1.1905 mL
	50 mM	0.0381 mL	0.1905 mL	0.3810 mL	0.9524 mL
	60 mM	0.0317 mL	0.1587 mL	0.3175 mL	0.7937 mL
	80 mM	0.0238 mL	0.1191 mL	0.2381 mL	0.5953 mL
	100 mM	0.0190 mL	0.0952 mL	0.1905 mL	0.4762 mL

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

TRC-766

Publications Citing Use of MedChemExpress (MCE) TRC-766