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Cat. No.: HY-156350

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SGC-STK17B-1

Name: SGC-STK17B-1
Brand: MedChemExpress
SKU: HY-156350
Price: 90.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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SGC-STK17B-1, a chemical probe, is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor (IC₅₀: 34 nM, K_D: 5.6 nM).

For research use only. We do not sell to patients.

Purity : 98.5%
CAS No.: 2650530-00-8
Formula: C₁₆H₁₀N₂O₂S₃
Molecular Weight:358.46

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SGC-STK17B-1 Chemical Structure

CAS No.: 2650530-00-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-W181026
KLF10-IN-1

KLF10 Inhibitor

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

SGC-STK17B-1, a chemical probe, is an ATP-competitive and selective STK17B (a member of DAPK family) inhibitor (IC₅₀: 34 nM, K_D: 5.6 nM)^[1].

IC₅₀ & Target

34 nM (STK17B)^[1].

Chemical Information

CAS No. 2650530-00-8
Appearance Solid
Molecular Weight 358.46
Formula C₁₆H₁₀N₂O₂S₃
Color Light yellow to yellow
SMILES

O=C(CSC1=NC=NC2=C1SC(C3=CC4=C(C=CC=C4)S3)=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Picado A, et al. A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J Med Chem. 2020 Dec 10;63(23):14626-14646. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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