SGK1-IN-5
SGK1-IN-5 is a SGK1 inhibitor with an IC50 of 0.003 μM. SGK1-IN-5 can be used for the research of osteoarthritis, rheumatism.
For research use only. We do not sell to patients.
- Purity : 98.2%
- CAS No.: 1426214-51-8
- Formula: C17H12Cl2N6O2S
- Molecular Weight:435.29
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-15192
GSK 650394SGK Inhibitor -
HY-15192R
GSK 650394 (Standard)SGK Inhibitor -
HY-15193
EMD638683SGK1 Inhibitor -
HY-117357
SI-113SGK1 Inhibitor -
HY-142687
SGK1-IN-4SGK1 Inhibitor -
HY-15193B
EMD638683 (S-Form)SGK1 Inhibitor -
HY-15193A
EMD638683 (R-Form)R-form -
HY-15193R
EMD638683 (Standard)Standard of EMD638683
Biological Activity
Description
IC50 & Target
[1]|
SGK1 0.003 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| U2OS | IC50 |
1.4 μM
Compound: 1
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Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hrs by fluorescence assay
Inhibition of recombinant human SGK1 (S61 to L431, S422D) expressed in human U20S cells assessed as inhibition of GSK3beta phosphorylation after 6 hrs by fluorescence assay
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[PMID: 24900601] |
| U2OS | IC50 |
1.4 μM
Compound: 14g
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Inhibition of SGK1 in human U2OS cells assessed as phosphorylation of GSK3beta
Inhibition of SGK1 in human U2OS cells assessed as phosphorylation of GSK3beta
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[PMID: 25589934] |
In Vitro
SGK1-IN-5 (example 1) inhibits SGK-1 depenent phosphorylation of GSK3beta in U2OS cells, with an IC50 of 1.4 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1426214-51-8
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Appearance Solid
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Molecular Weight 435.29
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Formula C17H12Cl2N6O2S
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Color Light yellow to yellow
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SMILES
O=S(C1=CC=CC(Cl)=C1Cl)(NC2=CC=C(C3=CN=C4C(NN=C4N)=N3)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SGK1-IN-5 Related Classifications
HY-128221 Related Classifications
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