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Cat. No.: HY-162233

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SHP2-IN-25

SHP2-IN-25 (Compound 6) is a SHP2 allosteric inhibitor, with an IC₅₀ of 225 nM. SHP2-IN-25 can be used for the research of cancer.

For research use only. We do not sell to patients.

Formula: C₂₂H₂₀F₃N₇S
Molecular Weight:471.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

SHP2-IN-25 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SHP2-IN-25 (Compound 6) is a SHP2 allosteric inhibitor, with an IC₅₀ of 225 nM. SHP2-IN-25 can be used for the research of cancer^[1].

Chemical Information

Molecular Weight 471.50
Formula C₂₂H₂₀F₃N₇S
SMILES

FC(F)(F)C1=NC=CC=C1SC2=NC3=C(N=C2)NC(NC[C@@H](CN4)C[C@H]4C5=CC=CC=C5)=N3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ponzi S, et al. Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors. Bioorg Med Chem Lett. 2024 Mar 1;100:129626. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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