Squalene synthase-IN-3
Squalene synthase-IN-3 is an orally active squalene synthase inhibitor with an IC50 value of 0.12 μM for both rat and human. Squalene synthase-IN-3 moderately reduces total plasma cholesterol and triglycerides in rats.
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- CAS. Nr.: 204061-69-8
- Formel: C22H25NO3
- Molecular Weight:351.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
squalene synthase 0.12 μM (IC50) |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male, 5 weeks old)[1]
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Dosage:50 mg/kg
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Administration:p.o.; twice daily; 4 days
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Result:After oral administration of compound 14 at 50 mg/kg twice daily for 4 days in rats (n=6), plasma total cholesterol was reduced by 14% and plasma triglycerides by 8% relative to control.
Control plasma total cholesterol was 80 mg/dL and control plasma triglycerides were 12 mg/dL.
Chemical Information
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CAS. Nr. 204061-69-8
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Molecular Weight 351.44
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Formel C22H25NO3
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SMILES
O=C1C2=C(OC3=CC=C(C(CC=C)=C31)OCCCNC(C)C)C=CC=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Squalene synthase-IN-3 Related Classifications
HY-189032 Related Classifications
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