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Cat. No.: HY-189032

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Squalene synthase-IN-3

Squalene synthase-IN-3 is an orally active squalene synthase inhibitor with an IC₅₀ value of 0.12 μM for both rat and human. Squalene synthase-IN-3 moderately reduces total plasma cholesterol and triglycerides in rats.

For research use only. We do not sell to patients.

CAS No.: 204061-69-8
Formula: C₂₂H₂₅NO₃
Molecular Weight:351.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Squalene synthase-IN-3 Chemical Structure

CAS No.: 204061-69-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

squalene synthase

0.12 μM (IC₅₀)

In Vitro

Squalene synthase-IN-3 (compound 14) inhibits rat liver microsomal squalene synthase with an IC₅₀ of 0.12 μM^[1].
Squalene synthase-IN-3 inhibits squalene synthase derived from HepG2 human hepatoma cells with an IC₅₀ of 0.12 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Squalene synthase-IN-3 (compound 14) (50 mg/kg; oral; twice daily; 4 days) produces a modest reduction in plasma total cholesterol and triglycerides after oral administration in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, 5 weeks old)^[1]
Dosage:

50 mg/kg
Administration:

p.o.; twice daily; 4 days
Result:

After oral administration of compound 14 at 50 mg/kg twice daily for 4 days in rats (n=6), plasma total cholesterol was reduced by 14% and plasma triglycerides by 8% relative to control.
Control plasma total cholesterol was 80 mg/dL and control plasma triglycerides were 12 mg/dL.

Chemical Information

CAS No. 204061-69-8
Molecular Weight 351.44
Formula C₂₂H₂₅NO₃
SMILES

O=C1C2=C(OC3=CC=C(C(CC=C)=C31)OCCCNC(C)C)C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ishihara T, et al. Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors. Bioorganic & medicinal chemistry. 2004 Nov 15;12(22):5899-908.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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