T Cell Lipid 15
T Cell Lipid 15 is an ionizable cationic lipid. T Cell Lipid 15 can be used to construct LNP targeting T cells. LNPs based on T Cell Lipid 15 induce reduced cytokine secretion, enable specific in vivo CD8+ T cell reprogramming, and cause minimal off-target transfection. T Cell Lipid 15 can be used for research on hematologic malignancies.
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- CAS No.: 3024023-96-6
- Formule: C58H108N2O7
- Masse moléculaire:945.49
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Lipid 15-based LNPs (0.1-1 μg/mL; 24 h) mediate excellent transfection efficiency in primary CD8+ T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NSG MHC I/II KO (female, 10 weeks old, engrafted with 10^7 human PBMCs)[1]
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Dosage:0.3 mg/kg
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Administration:i.v.
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Result:Achieved >20% of human CD8+ T cells in blood, spleen, and bone marrow expressing CD22 CAR (22-V4).
Showed increased GFP expression in liver CD8+ T cells over baseline, with <5% GFP expression in endothelial cells, macrophages, and hepatocytes compared to vehicle.
Maintained CD22 CAR expression levels in blood CD8+ T cells after the fourth repeated dose matching levels after the first dose.
Induced near-complete depletion of human CD19+ B cells in spleen and bone marrow compared to vehicle-treated animals.
Exhibited no significant differences in body weight changes or spleen weight relative to vehicle-treated animals.
Chemical Information
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CAS No. 3024023-96-6
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Masse moléculaire 945.49
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Formule C58H108N2O7
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SMILES
O=C(CCCCCCC/C=C\CCCCCCCC)OCC(COC(CCCCCCC/C=C\CCCCCCCC)=O)N(CCCN(C)C)C(CCC(OC(CCC)CCCCCC)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T Cell Lipid 15 Related Classifications
HY-188022 Related Classifications
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