T Cell Lipid 15
T Cell Lipid 15 is an ionizable cationic lipid. T Cell Lipid 15 can be used to construct LNP targeting T cells. LNPs based on T Cell Lipid 15 induce reduced cytokine secretion, enable specific in vivo CD8+ T cell reprogramming, and cause minimal off-target transfection. T Cell Lipid 15 can be used for research on hematologic malignancies.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 3024023-96-6
- Fòrmula: C58H108N2O7
- Peso molecular:945.49
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
Lipid 15-based LNPs (0.1-1 μg/mL; 24 h) mediate excellent transfection efficiency in primary CD8+ T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:NSG MHC I/II KO (female, 10 weeks old, engrafted with 10^7 human PBMCs)[1]
-
Dosage:0.3 mg/kg
-
Administration:i.v.
-
Result:Achieved >20% of human CD8+ T cells in blood, spleen, and bone marrow expressing CD22 CAR (22-V4).
Showed increased GFP expression in liver CD8+ T cells over baseline, with <5% GFP expression in endothelial cells, macrophages, and hepatocytes compared to vehicle.
Maintained CD22 CAR expression levels in blood CD8+ T cells after the fourth repeated dose matching levels after the first dose.
Induced near-complete depletion of human CD19+ B cells in spleen and bone marrow compared to vehicle-treated animals.
Exhibited no significant differences in body weight changes or spleen weight relative to vehicle-treated animals.
Chemical Information
-
No. CAS 3024023-96-6
-
Peso molecular 945.49
-
Fòrmula C58H108N2O7
-
SMILES
O=C(CCCCCCC/C=C\CCCCCCCC)OCC(COC(CCCCCCC/C=C\CCCCCCCC)=O)N(CCCN(C)C)C(CCC(OC(CCC)CCCCCC)=O)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T Cell Lipid 15 Related Classifications
HY-188022 Related Classifications
Powered by Bioz