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  4. TAMRA-PEG4-acid

TAMRA-PEG4-acid is a dye derivative of TAMRA (HY-135640) containing 3 PEG units.

For research use only. We do not sell to patients.

TAMRA-PEG4-acid

TAMRA-PEG4-acid Chemical Structure

CAS No. : 1909223-02-4

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TAMRA-PEG4-acid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

TAMRA-PEG4-acid is a dye derivative of TAMRA (HY-135640) containing 3 PEG units.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TAMRA-PEG4-acid Related Antibodies
Molecular Weight

677.80

Formula

C36H43N3O10
CAS No.
Appearance

Liquid

Color

Brown to reddish brown

SMILES

C/[N+](C)=C1C=CC2=C(C3=CC=C(C(NCCOCCOCCOCCOCCC(O)=O)=O)C=C3C([O-])=O)C4=CC=C(N(C)C)C=C4OC2=C/1.C/[N+](C)=C5C=CC6=C(C7=CC(C(NCCOCCOCCOCCOCCC(O)=O)=O)=CC=C7C([O-])=O)C8=CC=C(N(C)C)C=C8OC6=C/5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (147.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4754 mL 7.3768 mL 14.7536 mL
5 mM 0.2951 mL 1.4754 mL 2.9507 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4754 mL 7.3768 mL 14.7536 mL 36.8840 mL
5 mM 0.2951 mL 1.4754 mL 2.9507 mL 7.3768 mL
10 mM 0.1475 mL 0.7377 mL 1.4754 mL 3.6884 mL
15 mM 0.0984 mL 0.4918 mL 0.9836 mL 2.4589 mL
20 mM 0.0738 mL 0.3688 mL 0.7377 mL 1.8442 mL
25 mM 0.0590 mL 0.2951 mL 0.5901 mL 1.4754 mL
30 mM 0.0492 mL 0.2459 mL 0.4918 mL 1.2295 mL
40 mM 0.0369 mL 0.1844 mL 0.3688 mL 0.9221 mL
50 mM 0.0295 mL 0.1475 mL 0.2951 mL 0.7377 mL
60 mM 0.0246 mL 0.1229 mL 0.2459 mL 0.6147 mL
80 mM 0.0184 mL 0.0922 mL 0.1844 mL 0.4611 mL
100 mM 0.0148 mL 0.0738 mL 0.1475 mL 0.3688 mL
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TAMRA-PEG4-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAMRA-PEG4-acid1909223-02-4Fluorescent DyeInhibitorinhibitorinhibit

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