country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-138964

Copy Link Print Information

TC-PTP-IN-1

TC-PTP-IN-1 (compound 8) is a potent TC-PTP inhibitor with an IC₅₀ value of 9.2 nM, K_i values of 4.3, 34 nM for TC-PTP, PTP1B, respectively. TC-PTP-IN-1 increases the protein expression of pSre416. TC-PTP-IN-1 (compound 3) is the TC-PTP Ligand of TP1L (HY-160151).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1187396-28-6
分子式: C₄₆H₆₂F₂N₅O₉P
分子量:897.98

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TC-PTP-IN-1 構造式

CAS 番号: 1187396-28-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

TC-PTP-IN-1 (compound 8) is a potent TC-PTP inhibitor with an IC₅₀ value of 9.2 nM, K_i values of 4.3, 34 nM for TC-PTP, PTP1B, respectively. TC-PTP-IN-1 increases the protein expression of pSre416^[1]. TC-PTP-IN-1 (compound 3) is the TC-PTP Ligand of TP1L (HY-160151)^[2].

IC₅₀ & Target

TC-PTP

体外実験

TC-PTP-IN-1 (compound 8) (5-50 nM; 2 h) increases the protein expression of pSre416 in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

PTP1B−/− mouse embryo fibroblast cells
Concentration:

5, 10, 20, 50 nM
Incubation Time:

2 h
Result:

Increased the expression of pSre416 in a dose-dependent manner but shows no increases in pSrc527.

Related Protocols :

化学情報

CAS 番号 1187396-28-6
分子量 897.98
分子式 C₄₆H₆₂F₂N₅O₉P
SMILES

O=P(O)(O)C(F)(F)C(C=C1)=CC=C1C[C@@H](C(N[C@H](C(N)=O)CCCCNC(C2=CC=C(C=C2)CC)=O)=O)NC([C@@H](NC(CO[C@@H]3[C@H](CC[C@@H](C3)C)C(C)C)=O)CC4=CC=CC=C4)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhang S, et al. Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. J Am Chem Soc. 2009 Sep 16;131(36):13072-9. [Content Brief]

[2]. Miao J, et al. Discovery of a selective TC-PTP degrader for cancer immunotherapy. Chem Sci. 2023 Oct 24;14(44):12606-12614. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ