TC-PTP-IN-1
TC-PTP-IN-1 (compound 8) is a potent TC-PTP inhibitor with an IC50 value of 9.2 nM, Ki values of 4.3, 34 nM for TC-PTP, PTP1B, respectively. TC-PTP-IN-1 increases the protein expression of pSre416. TC-PTP-IN-1 (compound 3) is the TC-PTP Ligand of TP1L (HY-160151).
For research use only. We do not sell to patients.
- CAS No.: 1187396-28-6
- Formula: C46H62F2N5O9P
- Molecular Weight:897.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TC-PTP |
TC-PTP-IN-1 (compound 8) (5-50 nM; 2 h) increases the protein expression of pSre416 in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PTP1B−/− mouse embryo fibroblast cells
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Concentration:5, 10, 20, 50 nM
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Incubation Time:2 h
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Result:Increased the expression of pSre416 in a dose-dependent manner but shows no increases in pSrc527.
Chemical Information
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CAS No. 1187396-28-6
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Molecular Weight 897.98
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Formula C46H62F2N5O9P
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SMILES
O=P(O)(O)C(F)(F)C(C=C1)=CC=C1C[C@@H](C(N[C@H](C(N)=O)CCCCNC(C2=CC=C(C=C2)CC)=O)=O)NC([C@@H](NC(CO[C@@H]3[C@H](CC[C@@H](C3)C)C(C)C)=O)CC4=CC=CC=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Zhang S, et al. Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. J Am Chem Soc. 2009 Sep 16;131(36):13072-9. [Content Brief]
[2]. Miao J, et al. Discovery of a selective TC-PTP degrader for cancer immunotherapy. Chem Sci. 2023 Oct 24;14(44):12606-12614. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TC-PTP-IN-1 Related Classifications
HY-138964 Related Classifications
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