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Cat. No.: HY-132238

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Tetradecylphosphonic acid

(Synonyms: TDPA; Tetradecyl phosphonate)

Tetradecylphosphonic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

CAS No.: 4671-75-4
Formula: C₁₄H₃₁O₃P
Molecular Weight:278.37

Storage:

Store at room temperature, keep dry and cool.

In solvent -80°C, 1 year , -20°C, 6 months

Data Sheet (236 KB)

Tetradecylphosphonic acid Chemical Structure

CAS No.: 4671-75-4

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Biological Activity
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- Cellular Effect
- In Vitro
Chemical Information
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Biological Activity

Description

Tetradecylphosphonic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cellular Effect

Cell Line	Type	Value	Description	References
PC-3	IC₅₀	9674 nM Compound: 16c	Inhibition of LPA-induced calcium transients in PC-3 cells Inhibition of LPA-induced calcium transients in PC-3 cells	[PMID: 16033271]
RH7777	IC₅₀	3100 nM Compound: 16c	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA3 receptor Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA3 receptor	[PMID: 16033271]
RH7777	IC₅₀	5500 nM Compound: 16c	Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA2 receptor	[PMID: 16033271]

In Vitro

Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors. The IC50 value for inhibition of LPA-induced calcium mobilization was 10 μM, 5.5 μM, and 3.1 μM, respectively. At a concentration of 10 μM, tetradecyl phosphonate activates a peroxisome proliferator-activated receptor γ reporter construct 4-fold when compared with the controls and partially inhibits autotaxin with an IC50 value of approximately 3 μM. Lysophosphatidic acid (LPA) , also known as autotaxin (ATX ), is a lipid signaling molecule formed by the hydrolysis of lysophosphatidyl choline by lysophospholipase D. LPA signals through four different G protein-coupled receptors, named as LPA1/EDG-2, LPA2/EDG-4, LPA3/EDG-7, and LPA4/GPR23 . It has been reported that LPA was involved in activating peroxisome proliferator-activated receptor γ (PPARγ) .

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.