Tetradehydropodophyllotoxin (Synonyms: Dehydropodophyllotoxin)

Cat. No.: HY-N2502 Purity: 99.63%: Data Sheet
COA

SDS
Handling Instructions
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Tetradehydropodophyllotoxin possesses antifungal activity.

For research use only. We do not sell to patients.

Tetradehydropodophyllotoxin Chemical Structure

CAS No. : 42123-27-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Tetradehydropodophyllotoxin possesses antifungal activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	> 20 μg/mL Compound: 3	Cytotoxicity against human A431 cells Cytotoxicity against human A431 cells	[PMID: 8277312]
A549	IC₅₀	106.7 μM Compound: 6'b	Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay Cytotoxicity against Homo sapiens (human) A549 cells after 72 hr by MTT assay	10.1007/s00044-011-9937-1
Col2	ED₅₀	8.9 μg/mL Compound: 3	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 8277312]
HEK293	IC₅₀	240 μM Compound: 6'b	Cytotoxicity against Homo sapiens (human) HEK293 cells after 72 hr by MTT assay Cytotoxicity against Homo sapiens (human) HEK293 cells after 72 hr by MTT assay	10.1007/s00044-011-9937-1
HT	ED₅₀	9.7 μg/mL Compound: 3	Cytotoxicity against human HT cells Cytotoxicity against human HT cells	[PMID: 8277312]
HeLa	IC₅₀	8.28 μM Compound: 10	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 21570846]
KB	ED₅₀	4 μg/mL Compound: 4	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 2849640]
KB	ED₅₀	5 μg/mL Compound: 3	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8277312]
KB	IC₅₀	29.1 μM Compound: 6'b	Cytotoxicity against Homo sapiens (human) KB cells after 72 hr by MTT assay Cytotoxicity against Homo sapiens (human) KB cells after 72 hr by MTT assay	10.1007/s00044-011-9937-1
KB	IC₅₀	9.79 μM Compound: 10	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 21570846]
KB-V1	ED₅₀	13 μg/mL Compound: 3	Cytotoxicity against human KBV1 cells Cytotoxicity against human KBV1 cells	[PMID: 8277312]
LNCaP	ED₅₀	11.7 μg/mL Compound: 3	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 8277312]
Lu1	ED₅₀	10.6 μg/mL Compound: 3	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 8277312]
P388	ED₅₀	> 5 μg/mL Compound: 3	Cytotoxicity in mouse P388 cells Cytotoxicity in mouse P388 cells	[PMID: 8277312]
SW480	IC₅₀	> 100 μM Compound: 6'b	Cytotoxicity against Homo sapiens (human) SW480 cells after 72 hr by MTT assay Cytotoxicity against Homo sapiens (human) SW480 cells after 72 hr by MTT assay	10.1007/s00044-011-9937-1
U-373MG ATCC	ED₅₀	> 20 μg/mL Compound: 3	Cytotoxicity against human U373 cells Cytotoxicity against human U373 cells	[PMID: 8277312]
ZR-75-1	ED₅₀	> 20 μg/mL Compound: 3	Cytotoxicity against human ZR-75-1 cells Cytotoxicity against human ZR-75-1 cells	[PMID: 8277312]

Molecular Weight

410.37

Formula

C₂₂H₁₈O₈

CAS No.

42123-27-3

Appearance

Solid

Color

White to off-white

SMILES

O=C1OCC2=C(C3=C(C(C4=CC(OC)=C(C(OC)=C4)OC)=C12)C=C5OCOC5=C3)O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (24.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4368 mL	12.1841 mL	24.3683 mL
5 mM	0.4874 mL	2.4368 mL	4.8737 mL
10 mM	0.2437 mL	1.2184 mL	2.4368 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.63%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (256 KB) HNMR (265 KB) RP-HPLC (246 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Atta-ur-Rahman, et al. Antifungal aryltetralin lignans from leaves of Podophyllum hexandrum. Phytochemistry. Volume 40, Issue 2, September 1995, Pages 427-431

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4368 mL	12.1841 mL	24.3683 mL	60.9206 mL
	5 mM	0.4874 mL	2.4368 mL	4.8737 mL	12.1841 mL
	10 mM	0.2437 mL	1.2184 mL	2.4368 mL	6.0921 mL
	15 mM	0.1625 mL	0.8123 mL	1.6246 mL	4.0614 mL
	20 mM	0.1218 mL	0.6092 mL	1.2184 mL	3.0460 mL

Tetradehydropodophyllotoxin Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetradehydropodophyllotoxin42123-27-3DehydropodophyllotoxinFungalInhibitorinhibitorinhibit

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Tetradehydropodophyllotoxin (Synonyms: Dehydropodophyllotoxin)

Customer Review

Tetradehydropodophyllotoxin Related Antibodies

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Biological Activity

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References

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Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Tetradehydropodophyllotoxin Related Classifications

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