Tetrazine-Ph-NHCO-C3-NHS ester

Name: Tetrazine-Ph-NHCO-C3-NHS ester
Brand: MedChemExpress
SKU: HY-133479
Rating: 4.5 (0 reviews)

製品番号: HY-133479 純度: 98.40%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Tetrazine-Ph-NHCO-C3-NHS ester 構造式

CAS 番号 : 1244040-64-9

容量	価格（税別）	在庫状況	数量
5 mg	$190	在庫あり	Estimated Time of Arrival: December 31
10 mg	$310	在庫あり	Estimated Time of Arrival: December 31
25 mg	$620	在庫あり	Estimated Time of Arrival: December 31
50 mg	$990	在庫あり	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 0 publication(s) in Google Scholar

PROTAC Linkers アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

IC₅₀ & Target

PEGs

体外実験

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

398.37

分子式

C₁₈H₁₈N₆O₅

CAS 番号

1244040-64-9

Appearance

Solid

Color

Pink to red

SMILES

O=C(CCCC(ON1C(CCC1=O)=O)=O)NCC2=CC=C(C3=NN=CN=N3)C=C2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (251.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5102 mL	12.5511 mL	25.1023 mL
5 mM	0.5020 mL	2.5102 mL	5.0205 mL
10 mM	0.2510 mL	1.2551 mL	2.5102 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.40%

Select Batch:

データシート (269 KB) SDS (392 KB)

COA (246 KB) HNMR (273 KB) LCMS (94 KB)

取扱説明書 (2659 KB)

参考文献

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5102 mL	12.5511 mL	25.1023 mL	62.7557 mL
	5 mM	0.5020 mL	2.5102 mL	5.0205 mL	12.5511 mL
	10 mM	0.2510 mL	1.2551 mL	2.5102 mL	6.2756 mL
	15 mM	0.1673 mL	0.8367 mL	1.6735 mL	4.1837 mL
	20 mM	0.1255 mL	0.6276 mL	1.2551 mL	3.1378 mL
	25 mM	0.1004 mL	0.5020 mL	1.0041 mL	2.5102 mL
	30 mM	0.0837 mL	0.4184 mL	0.8367 mL	2.0919 mL
	40 mM	0.0628 mL	0.3138 mL	0.6276 mL	1.5689 mL
	50 mM	0.0502 mL	0.2510 mL	0.5020 mL	1.2551 mL
	60 mM	0.0418 mL	0.2092 mL	0.4184 mL	1.0459 mL
	80 mM	0.0314 mL	0.1569 mL	0.3138 mL	0.7844 mL
	100 mM	0.0251 mL	0.1255 mL	0.2510 mL	0.6276 mL