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Cat. No.: HY-187625

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Tgg-II-23A

Tgg-II-23A is a non-nucleoside HIV-1 reverse transcriptase inhibitor, with an IC₅₀ of 136 μM against HIV-1 NL4-3 reverse transcriptase. Tgg-II-23A exhibits antiviral activity against wild-type HIV-1, but shows reduced activity against TIBO R82150 (HY-19111)-resistant HIV-1 strains carrying reverse transcriptase mutations. Tgg-II-23A does not inhibit the replication of HIV-2. Tgg-II-23A can be used in studies related to HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 153312-20-0
Formula: C₁₇H₁₉NO₂
Molecular Weight:269.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tgg-II-23A Chemical Structure

CAS No.: 153312-20-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

HIV-1

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	EC50	27 μM	Inhibition of HIV-1 RF replication in human CEM-SS T cells by XTT dye reduction assay after 6 days of incubation post-infection. Inhibition of HIV-1 RF replication in human CEM-SS T cells by XTT dye reduction assay after 6 days of incubation post-infection.	7506510
CEM-SS	CC₅₀	550 μM	Cytotoxicity against human CEM-SS T cells by XTT dye reduction assay after 6 days of incubation post-infection. Cytotoxicity against human CEM-SS T cells by XTT dye reduction assay after 6 days of incubation post-infection.	7506510
MT2	EC50	13 μM	Inhibition of HIV-1 (pNL4-3) infection in human MT-2 T cells by XTT dye reduction assay after 6 days of incubation post-infection. Inhibition of HIV-1 (pNL4-3) infection in human MT-2 T cells by XTT dye reduction assay after 6 days of incubation post-infection.	7506510
CEM-SS	EC50	>1000 μM	Inhibition of HIV-2 CBL-20 replication in human CEM-SS T cells by XTT dye reduction assay after 6 days of incubation post-infection, with no measurable inhibition observed at concentrations up to 1000 μM. Inhibition of HIV-2 CBL-20 replication in human CEM-SS T cells by XTT dye reduction assay after 6 days of incubation post-infection, with no measurable inhibition observed at concentrations up to 1000 μM.	7506510
CEM-SS	IC50	19.1 μM	Antiviral activity against CEM-SS cells infected with parental wild-type HIV-1 RF strain measured via XTT formazan production to determine cell viability relative to untreated control cells. Antiviral activity against CEM-SS cells infected with parental wild-type HIV-1 RF strain measured via XTT formazan production to determine cell viability relative to untreated control cells.	095632029400500410

In Vitro

Tgg-II-23A (6 days) potently inhibits HIV-1 RF replication in vitro CEM-SS cells at non-cytotoxic concentrations^[1].
Tgg-II-23A (800 μM) shows no activity against HIV-2 EHO infection in CEM-SS cells at 800 μM, confirming its HIV-1 selective antiviral profile^[1].
Tgg-II-23A (1 h) directly inhibits purified recombinant wild-type HIV-1 NL4-3 reverse transcriptase in a cell-free biochemical assay using poly(rC):oligo(dG) template:primer, with an IC₅₀ of 136 μM^[1].
Tgg-II-23A (1 h) has drastically reduced inhibitory activity against Y181C mutant HIV-1 reverse transcriptase when assayed with poly(rA):oligo(dT) template:primer, with an IC₅₀ of 10900 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

CEM-SS human T cells
Concentration:

Serial dilutions
Incubation Time:

6 day (post-infection); 4 h (XTT incubation)
Result:

Inhibited HIV-1 RF replication with an EC₅₀ of 27 μM, and produced 50% cytotoxicity in CEM-SS cells at a CC₅₀ of 550 μM.
Returned an EC₅₀ of 26 μM and a CC₅₀ of 550 μM in additional replicate testing.

Chemical Information

CAS No. 153312-20-0
Molecular Weight 269.34
Formula C₁₇H₁₉NO₂
SMILES

O=C1C=C(C=2C=CC=CC2C1(C3=NC(C)(C)CO3)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Alam M, et al. Substituted naphthalenones as a new structural class of HIV-1 reverse transcriptase inhibitors. Antiviral research. 1993 Oct;22(2-3):131-41.

[2]. Samanta H, et al. Characterization of a Mutant HIV-1 Reverse Transcriptase Resistant to (+)-(5S)-4, 5, 6, 7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)-imidazo [4, 5, 1-jk][1, 4] benzodiazepin-2 (1 H)-thione (TIBO R82150)[J]. Antiviral Chemistry and Chemotherapy, 1994, 5(4): 278-281.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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