R-82150
R-82150 (TIBO-R 82150) is an HIV-1 reverse transcriptase inhibitor that blocks the reverse transcription of viral RNA by binding to the non-substrate binding site of reverse transcriptase, thereby inhibiting viral replication. R-82150 does not inhibit the replication of HIV-2, other RNA viruses, and DNA viruses.
For research use only. We do not sell to patients.
- CAS No.: 126320-77-2
- Formula: C16H21N3S
- Molecular Weight:287.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CEM-SS | CC50 |
79 μM
Compound: R-82150
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Tested for the cytotoxicity against CEM-SS cells (determined by the inhibition of [3H]-thymidine uptake)
Tested for the cytotoxicity against CEM-SS cells (determined by the inhibition of [3H]-thymidine uptake)
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10.1016/S0960-894X(01)81224-5 |
| CEM-SS | IC50 |
0.026 μM
Compound: R-82150
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Tested for the inhibition of HIV-1 in CEM-SS cells measured using Syncytial assay
Tested for the inhibition of HIV-1 in CEM-SS cells measured using Syncytial assay
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10.1016/S0960-894X(01)81224-5 |
| Lymphocyte | EC50 |
0.021 μg/mL
Compound: TIBO R-82150
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Concentration required to inhibit HIV-1 induced cytopathicity in human MT-4 lymphocyte cells.
Concentration required to inhibit HIV-1 induced cytopathicity in human MT-4 lymphocyte cells.
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[PMID: 1495006] |
| MT2 | IC50 |
0.217 μM
Compound: TIBO
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Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells
Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells
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[PMID: 7689109] |
| MT4 | CC50 |
>20 μg/mL
Compound: TIBO R-82150
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Concentration required to reduce human MT-4 cell viability by 50%.
Concentration required to reduce human MT-4 cell viability by 50%.
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[PMID: 1495006] |
| MT4 | CC50 |
>80 μM
Compound: TIBO R-82150
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Cytotoxic concentration required to reduce MT-4 cell viability by 50%
Cytotoxic concentration required to reduce MT-4 cell viability by 50%
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[PMID: 1501224] |
| MT4 | EC50 |
0.076 μM
Compound: TIBO R-82150
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Concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cells by 50%
Concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cells by 50%
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[PMID: 1501224] |
| MT4 | IC50 |
0.044 μM
Compound: 1
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Effective concentration of compound required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1
Effective concentration of compound required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1
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[PMID: 7877144] |
| MT4 | IC50 |
0.097 μM
Compound: 10a
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Ability to block replication of HIV-1 virus in mock infected MT-4 cells
Ability to block replication of HIV-1 virus in mock infected MT-4 cells
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[PMID: 1956037] |
| MT4 | IC50 |
0.097 μM
Compound: 1ca
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Effective concentration of compound required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1 number of experiments = 7
Effective concentration of compound required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1 number of experiments = 7
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[PMID: 7877143] |
| MT4 | IC50 |
28 nM
Compound: 11
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Antiviral activity against HIV1 3B infected in MT4 cells
Antiviral activity against HIV1 3B infected in MT4 cells
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[PMID: 22268494] |
Chemical Information
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CAS No. 126320-77-2
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Molecular Weight 287.42
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Formula C16H21N3S
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SMILES
S=C1NC2=C(N1C[C@H](C)N(C/C=C(C)\C)C3)C3=CC=C2
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Synonyms
TIBO-R 82150
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
R-82150 Related Classifications
HY-19111 Related Classifications
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