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Referencia número: HY-19111

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R-82150

Name: R-82150
Brand: MedChemExpress
SKU: HY-19111
Availability: PreOrder

(Synonyms: TIBO-R 82150)

R-82150 (TIBO-R 82150) is an HIV-1 reverse transcriptase inhibitor that blocks the reverse transcription of viral RNA by binding to the non-substrate binding site of reverse transcriptase, thereby inhibiting viral replication. R-82150 does not inhibit the replication of HIV-2, other RNA viruses, and DNA viruses.

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No. CAS: 126320-77-2
Fòrmula: C₁₆H₂₁N₃S
Peso molecular:287.42

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

R-82150 Chemical Structure

No. CAS: 126320-77-2

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
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Referencias
Calculators
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	CC₅₀	79 μM Compound: R-82150	Tested for the cytotoxicity against CEM-SS cells (determined by the inhibition of [3H]-thymidine uptake) Tested for the cytotoxicity against CEM-SS cells (determined by the inhibition of [3H]-thymidine uptake)	10.1016/S0960-894X(01)81224-5
CEM-SS	IC₅₀	0.026 μM Compound: R-82150	Tested for the inhibition of HIV-1 in CEM-SS cells measured using Syncytial assay Tested for the inhibition of HIV-1 in CEM-SS cells measured using Syncytial assay	10.1016/S0960-894X(01)81224-5
Lymphocyte	EC₅₀	0.021 μg/mL Compound: TIBO R-82150	Concentration required to inhibit HIV-1 induced cytopathicity in human MT-4 lymphocyte cells. Concentration required to inhibit HIV-1 induced cytopathicity in human MT-4 lymphocyte cells.	[PMID: 1495006]
MT2	IC₅₀	0.217 μM Compound: TIBO	Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells Inhibitory concentration which prevents the spread of HIV-1 IIIB infection in MT2 T-lymphoid cells	[PMID: 7689109]
MT4	CC₅₀	>20 μg/mL Compound: TIBO R-82150	Concentration required to reduce human MT-4 cell viability by 50%. Concentration required to reduce human MT-4 cell viability by 50%.	[PMID: 1495006]
MT4	CC₅₀	>80 μM Compound: TIBO R-82150	Cytotoxic concentration required to reduce MT-4 cell viability by 50% Cytotoxic concentration required to reduce MT-4 cell viability by 50%	[PMID: 1501224]
MT4	EC₅₀	0.076 μM Compound: TIBO R-82150	Concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cells by 50% Concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cells by 50%	[PMID: 1501224]
MT4	IC₅₀	0.044 μM Compound: 1	Effective concentration of compound required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1 Effective concentration of compound required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1	[PMID: 7877144]
MT4	IC₅₀	0.097 μM Compound: 10a	Ability to block replication of HIV-1 virus in mock infected MT-4 cells Ability to block replication of HIV-1 virus in mock infected MT-4 cells	[PMID: 1956037]
MT4	IC₅₀	0.097 μM Compound: 1ca	Effective concentration of compound required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1 number of experiments = 7 Effective concentration of compound required to achieve 50% protection of MT-4 cells against the cytopathic effect of HIV-1 number of experiments = 7	[PMID: 7877143]
MT4	IC₅₀	28 nM Compound: 11	Antiviral activity against HIV1 3B infected in MT4 cells Antiviral activity against HIV1 3B infected in MT4 cells	[PMID: 22268494]

Chemical Information

No. CAS 126320-77-2
Peso molecular 287.42
Fòrmula C₁₆H₂₁N₃S
SMILES

S=C1NC2=C(N1C[C@H](C)N(C/C=C(C)\C)C3)C3=CC=C2
Synonyms

TIBO-R 82150
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Parker K A, et al. A four-step synthesis of TIBO R82150[J]. The Journal of Organic Chemistry, 1991, 56(15): 4600-4601.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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