Triethylene glycol diacetate

Name: Triethylene glycol diacetate
Brand: MedChemExpress
SKU: HY-W102352
Rating: 4.5 (0 reviews)

Cat. No.: HY-W102352 Purity: 98.50%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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Triethylene glycol diacetate is an orally active Triethylene glycol (HY-W017440) derivative with reproduction toxicity. Triethylene glycol diacetate reduces body weights of nursing mouse pups during lactation, with effects reversing by young adulthood, and increases combined kidney/adrenal weight in adult. Triethylene glycol diacetate can be used for the research of reproductive and developmental toxicity.

For research use only. We do not sell to patients.

Triethylene glycol diacetate Chemical Structure

CAS No. : 111-21-7

Size	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Liquid
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vivo

Triethylene glycol diacetate (Compound TGD) (1.36-5.45 g/kg; in drinking water; 98 days) does not cause reproductive toxicity in Swiss CD-1 mice but induces reversible developmental toxicity (reduced pup weights on Postnatal days 14 and 21) at the highest dose (5.45 g/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss CD-1 (outbred Swiss albino, COBS Cr 1 CD-1 (ICR)BR, 6 weeks of age)^[1]
Dosage:	1.36, 2.74, 5.45 g/kg
Administration:	In drinking water; 98 days
Result:	Observed no effects on fertility or reproductive performance (number of litters per pair, live pups per litter, proportion of pups born alive, live pup weight at birth) at doses up to 3%. Reduced pup body weights significantly in the 3% group on Postnatal days 14 and 21, with no difference apparent by day 74. Increased combined kidney/adrenal weight significantly in F₁ males and females exposed to 5.45 g/kg. Observed no effects on sperm motility, concentration, or morphology in F1 males exposed to 5.45 g/kg. Had no significant effect on the proportion of detected matings or fertile pairs, live F₂ pups per litter, proportion of F₂ pups born alive, sex of F₂ pups born alive, or live F₂ pup weight.

Molecular Weight

234.25

Formula

C₁₀H₁₈O₆

CAS No.

111-21-7

Appearance

Liquid (Density: 1,12 g/cm³)

SMILES

CC(=O)OCCOCCOCCOC(=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	1 year
	-20°C	6 months

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (853.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2689 mL	21.3447 mL	42.6894 mL
5 mM	0.8538 mL	4.2689 mL	8.5379 mL
10 mM	0.4269 mL	2.1345 mL	4.2689 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (21.34 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (21.34 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (21.34 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.50%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (241 KB)

Handling Instructions (2659 KB)

References

[1]. Bossert NL, et al. Reproductive toxicity of triethylene glycol and its diacetate and dimethyl ether derivatives in a continuous breeding protocol in Swiss CD-1 mice. Fundam Appl Toxicol. 1992;18(4):602-608. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.2689 mL	21.3447 mL	42.6894 mL	106.7236 mL
	5 mM	0.8538 mL	4.2689 mL	8.5379 mL	21.3447 mL
	10 mM	0.4269 mL	2.1345 mL	4.2689 mL	10.6724 mL
	15 mM	0.2846 mL	1.4230 mL	2.8460 mL	7.1149 mL
	20 mM	0.2134 mL	1.0672 mL	2.1345 mL	5.3362 mL
	25 mM	0.1708 mL	0.8538 mL	1.7076 mL	4.2689 mL
	30 mM	0.1423 mL	0.7115 mL	1.4230 mL	3.5575 mL
	40 mM	0.1067 mL	0.5336 mL	1.0672 mL	2.6681 mL
	50 mM	0.0854 mL	0.4269 mL	0.8538 mL	2.1345 mL
	60 mM	0.0711 mL	0.3557 mL	0.7115 mL	1.7787 mL
	80 mM	0.0534 mL	0.2668 mL	0.5336 mL	1.3340 mL
	100 mM	0.0427 mL	0.2134 mL	0.4269 mL	1.0672 mL