Triethylene glycol diacetate
Based on 1 Customer Validation
Triethylene glycol diacetate is an orally active Triethylene glycol (HY-W017440) derivative with reproduction toxicity. Triethylene glycol diacetate reduces body weights of nursing mouse pups during lactation, with effects reversing by young adulthood, and increases combined kidney/adrenal weight in adult. Triethylene glycol diacetate can be used for the research of reproductive and developmental toxicity.
For research use only. We do not sell to patients.
- Purity: 98.50%
- CAS No.: 111-21-7
- Formula: C10H18O6
- Molecular Weight:234.25
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Storage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss CD-1 (outbred Swiss albino, COBS Cr 1 CD-1 (ICR)BR, 6 weeks of age)[1]
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Dosage:1.36, 2.74, 5.45 g/kg
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Administration:In drinking water; 98 days
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Result:Observed no effects on fertility or reproductive performance (number of litters per pair, live pups per litter, proportion of pups born alive, live pup weight at birth) at doses up to 3%.
Reduced pup body weights significantly in the 3% group on Postnatal days 14 and 21, with no difference apparent by day 74.
Increased combined kidney/adrenal weight significantly in F1 males and females exposed to 5.45 g/kg.
Observed no effects on sperm motility, concentration, or morphology in F1 males exposed to 5.45 g/kg.
Had no significant effect on the proportion of detected matings or fertile pairs, live F2 pups per litter, proportion of F2
pups born alive, sex of F2 pups born alive, or live F2 pup
weight.
Chemical Information
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CAS No. 111-21-7
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Appearance Liquid (Density: 1,12 g/cm3)
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Molecular Weight 234.25
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Formula C10H18O6
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SMILES
CC(=O)OCCOCCOCCOC(=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Solvent & Solubility
DMSO : 200 mg/mL (853.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (21.34 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (21.34 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.2689 mL | 21.3447 mL | 42.6894 mL | 106.7236 mL |
| 5 mM | 0.8538 mL | 4.2689 mL | 8.5379 mL | 21.3447 mL | |
| 10 mM | 0.4269 mL | 2.1345 mL | 4.2689 mL | 10.6724 mL | |
| 15 mM | 0.2846 mL | 1.4230 mL | 2.8460 mL | 7.1149 mL | |
| 20 mM | 0.2134 mL | 1.0672 mL | 2.1345 mL | 5.3362 mL | |
| 25 mM | 0.1708 mL | 0.8538 mL | 1.7076 mL | 4.2689 mL | |
| 30 mM | 0.1423 mL | 0.7115 mL | 1.4230 mL | 3.5575 mL | |
| 40 mM | 0.1067 mL | 0.5336 mL | 1.0672 mL | 2.6681 mL | |
| 50 mM | 0.0854 mL | 0.4269 mL | 0.8538 mL | 2.1345 mL | |
| 60 mM | 0.0711 mL | 0.3557 mL | 0.7115 mL | 1.7787 mL | |
| 80 mM | 0.0534 mL | 0.2668 mL | 0.5336 mL | 1.3340 mL | |
| 100 mM | 0.0427 mL | 0.2134 mL | 0.4269 mL | 1.0672 mL |
Triethylene glycol diacetate Related Classifications
HY-W102352 Related Classifications
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