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Cat. No.: HY-146997

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TRβ agonist 1

TRβ agonist 1 is a selective and mutation-sensitive thyroid hormone receptor β (TRβ) agonist, with an EC₅₀ value of 21 nM. TRβ agonist 1 can be used for researching dyslipidemia, nonalcoholic steatohepatitis (NASH), and resistance to thyroid hormone (RTH).

For research use only. We do not sell to patients.

CAS No.: 2770681-85-9
Formula: C₂₉H₂₅FN₂O₈
Molecular Weight:548.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TRβ agonist 1 Chemical Structure

CAS No.: 2770681-85-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

EC₅₀: 21.0 nM [TRβ (WT)], 1344.0 nM [TRβ (H435R)]^[1]

In Vitro

TRβ agonist 1 (compound 16g) (1, 3, 10 μM; 24 hours) reduces lipid accumulation and cholesterol levels by triglyceride (TG) and total cholesterol (TC) analyses in HepG2 cells and primary mouse hepatocytes; also reduces the total lipid accumulation at 10 μM^[1].
TRβ agonist 1 (10 μM; 24 hours) induces a significant enhancement of the p-AMPK/AMPK ratio, the p-ACC/ACC ratio, and CPT1 levels^[1].
TRβ agonist 1 (0.01, 0.1, 1 and 10 μM; 24 hours) does not display significant cellular toxicity on multiple cell lines (HepG2, 22Rv1, A549, MCF7, MDA-MB-231, HFL-1, and BxPC-3) at concentrations up to 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2770681-85-9
Molecular Weight 548.52
Formula C₂₉H₂₅FN₂O₈
SMILES

O=C(C1=C(C2=CC=C(C=C2C(OC)=N1)OC3=C(C=C(C=C3C)C(C4=CC(OC)=CC(F)=C4)=O)C)O)NCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Q, et al. Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor β Agonist. J Med Chem. 2022;65(10):7193-7211. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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