Tubulin polymerization-IN-18
Tubulin polymerization-IN-18 (compound 8) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-18 has the potential for the research of breast cancers and chemoresistant colon cancers.
For research use only. We do not sell to patients.
- CAS No.: 1258011-23-2
- Formula: C25H25NO6
- Molecular Weight:435.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Epithelial cell | IC50 |
10 mM
Compound: 35
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Cytotoxicity against in CD1 mouse mammary epithelial cells after 72 hrs by alamar blue dye assay
Cytotoxicity against in CD1 mouse mammary epithelial cells after 72 hrs by alamar blue dye assay
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[PMID: 21080725] |
| HT-29 | IC50 |
0.43 μM
Compound: 5a
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Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
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[PMID: 31954879] |
| MCF7 | IC50 |
0.004 μM
Compound: 5a
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay
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[PMID: 31954879] |
| MCF7 | IC50 |
0.0096 μM
Compound: 35
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
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[PMID: 21080725] |
| MDA-MB-231 | IC50 |
0.0288 μM
Compound: 35
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Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
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[PMID: 21080725] |
Chemical Information
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CAS No. 1258011-23-2
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Molecular Weight 435.47
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Formula C25H25NO6
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SMILES
COC1=CC(N2C([C@H]([C@@H]2C3=CC(O)=C(C=C3)OC)C4=CC=CC=C4)=O)=CC(OC)=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tubulin polymerization-IN-18 Related Classifications
HY-146376 Related Classifications
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