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Cat. No.: HY-16069AR

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Tucatinib hemiethanolate (Standard)

(Synonyms: Irbinitinib hemiethanolate (Standard); ARRY-380 hemiethanolate (Standard); ONT-380 hemiethanolate (Standard))

Tucatinib (hemiethanolate) (Standard) is the analytical standard of Tucatinib (hemiethanolate). This product is intended for research and analytical applications. Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.

For research use only. We do not sell to patients.

CAS No.: 1429755-56-5
Formula: C₂₆H₂₄N₈O₂.1/2C₂H₆O
Molecular Weight:503.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tucatinib hemiethanolate (Standard) Chemical Structure

CAS No.: 1429755-56-5

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1429755-56-5
Molecular Weight 503.57
Formula C₂₆H₂₄N₈O₂.1/2C₂H₆O
SMILES

CC1=CC(NC2=C3C=C(NC4=NC(C)(C)CO4)C=CC3=NC=N2)=CC=C1OC5=CC6=NC=NN6C=C5.CCO
Synonyms

Irbinitinib hemiethanolate (Standard); ARRY-380 hemiethanolate (Standard); ONT-380 hemiethanolate (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Moulder-Thompson S, et al. Phase 1 Study of ONT-380, a HER2 Inhibitor, in Patients with HER2⁺ Advanced Solid Tumors, with an Expansion Cohort in HER2+ Metastatic Breast Cancer (MBC). Clin Cancer Res. 2017 Jan 4. pii: clincanres.1496.2016. [Content Brief]

[2]. Abstract: In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 852. doi:1538-7445.AM2012-852.

[3]. P. Lee, et al. In Vivo Activity of ARRY-380, a Potent, Small Molecule Inhibitor of ErbB2 in Combination with RP-56976. Cancer Research.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Tucatinib hemiethanolate (Standard)

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Tucatinib hemiethanolate (Standard)

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Tucatinib hemiethanolate (Standard) Related Classifications

HY-16069AR Related Classifications