Bemotrizinol
Based on 1 Customer Validation
Bemotrizinol (Tinosorb S), a compound that can absorb ultraviolet light, has been shown to accept atomic oxygen generated by N-oxide photodeoxygenation.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 187393-00-6
- Formula: C38H49N3O5
- Molecular Weight:627.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Bemotrizinol can be used as a UV filter to filter UV radiation in the range of 280-380 nm. Bemotrizinol can be used in the study of sunscreen cosmetics without causing skin penetration. The SPF value of the carrier containing Bemotrizinol loaded nanostructured lipid carrier (NLC) increased by about 20%[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 187393-00-6
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Appearance Solid
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Molecular Weight 627.81
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Formula C38H49N3O5
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Color White to light yellow
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SMILES
CCCCC(CC)COC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=CC=C(C=C3)OC)C4=C(C=C(C=C4)OCC(CC)CCCC)O)O
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Synonyms
Tinosorb S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Chloroform : 50 mg/mL (79.64 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Durán-Giner N, et al. Solar filters as feasible acceptors of atomic oxygen. Photochem Photobiol Sci. 2013;12(5):725-728. [Content Brief]
[2]. D'Ruiz CD, et al. Preliminary clinical pharmacokinetic evaluation of bemotrizinol - A new sunscreen active ingredient being considered for inclusion under FDA's over-the-counter (OTC) sunscreen monograph. Regul Toxicol Pharmacol. 2023 Mar;139:105344. [Content Brief]
[4]. Yap FH, et al. Active sunscreen ingredients in Australia. Australas J Dermatol. 2017 Nov;58(4):e160-e170. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Chloroform | 1 mM | 1.5928 mL | 7.9642 mL | 15.9284 mL | 39.8210 mL |
| 5 mM | 0.3186 mL | 1.5928 mL | 3.1857 mL | 7.9642 mL | |
| 10 mM | 0.1593 mL | 0.7964 mL | 1.5928 mL | 3.9821 mL | |
| 15 mM | 0.1062 mL | 0.5309 mL | 1.0619 mL | 2.6547 mL | |
| 20 mM | 0.0796 mL | 0.3982 mL | 0.7964 mL | 1.9910 mL | |
| 25 mM | 0.0637 mL | 0.3186 mL | 0.6371 mL | 1.5928 mL | |
| 30 mM | 0.0531 mL | 0.2655 mL | 0.5309 mL | 1.3274 mL | |
| 40 mM | 0.0398 mL | 0.1991 mL | 0.3982 mL | 0.9955 mL | |
| 50 mM | 0.0319 mL | 0.1593 mL | 0.3186 mL | 0.7964 mL | |
| 60 mM | 0.0265 mL | 0.1327 mL | 0.2655 mL | 0.6637 mL |
Bemotrizinol Related Classifications
HY-W099730 Related Classifications
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