AKR7A2 - aldo-keto reductase family 7 member A2 Gene

Also Known as AFAR; AKR7; AFAR1; AFB1-AR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8574

About AKR7A2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,302,708-19,312,146 (from NCBI)

This gene has 5 transcripts (splice variants), 249 orthologues and 16 paralogues. Ubiquitous expression in kidney (RPKM 26.6), duodenum (RPKM 20.0) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

AKR7A2 Products (2)

mRNA Protein Name
NM_001320979.1 NP_001307908.1 aflatoxin B1 aldehyde reductase member 2 isoform 2
NM_003689.4 NP_003680.2 aflatoxin B1 aldehyde reductase member 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phenanthrene-9,10-epoxide hydrolase activity IDA
IDA: Inferred from direct assay
20837989 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in daunorubicin metabolic process IMP
IMP: Inferred from mutant phenotype
20837989 GOA
involved in doxorubicin metabolic process IMP
IMP: Inferred from mutant phenotype
20837989 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR7A2 Protein Structure

Aldo_ket_red

Aldo_ket_red: Aldo/keto reductase family (41 - 346)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

aflatoxin B1 aldehyde reductase member 2

  • AFB1 aldehyde reductase 1

AKR7A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AKR7A2 O43488 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
AKR7A2 O43488 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
AKR7A2 O43488 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
AKR7A2 O43488 ZBTB1 Homo sapiens Q9Y2K1
Y2H Prey Pooling
32296183
Intra
AKR7A2 O43488 ZBTB1 Homo sapiens Q9Y2K1
Y2H Array
32296183
Intra
AKR7A2 O43488 ZBTB1 Homo sapiens Q9Y2K1
Validated Y2H
32296183
Intra
AKR7A2 O43488 AKR7A3 Homo sapiens O95154
Anti Tag CoIP
33961781
Intra
AKR7A2 O43488 AKR7A3 Homo sapiens O95154
Validated Y2H
32296183
Intra
AKR7A2 O43488 AKR7A3 Homo sapiens O95154
Y2H Array
32296183
Intra
AKR7A2 O43488 AKR7A3 Homo sapiens O95154
Y2H Prey Pooling
32296183
Intra
AKR7A2 O43488 AKR7A3 Homo sapiens O95154
Y2H Pooling
16189514
Intra
AKR7A2 O43488 ATXN3 Homo sapiens P54252
Y2H Array
32814053
Intra
AKR7A2 O43488 ATXN3 Homo sapiens P54252
Validated Y2H
32814053
Intra
AKR7A2 O43488 ATXN3 Homo sapiens P54252
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gamma-Amino Butyric Acid Metabolism Disorder

  • Disorder Of Gamma-Aminobutyric Acid Metabolism

  • Disorder Of Gaba Metabolism

  • Disorders Of Gaba - [Gamma Aminobutyric Acid] Metabolism
Succinic Semialdehyde Dehydrogenase Deficiency

  • 4-Hydroxybutyric Aciduria

  • Ssadh Deficiency

  • Gamma-Hydroxybutyric Aciduria

  • Gaba Metabolic Defect

  • SSADHD

  • Ssadh

  • Succinate-Semialdehyde Dehydrogenase Deficiency

  • Gamma-Hydroxybutyricaciduria

  • 4-Hydroxybutyricaciduria

  • Gamma-Hydroxybutyric Acidemia

  • Succinate Semialdehyde Dehydrogenase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00540 AKR7A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AKR7A2 RGD RGD:620311
Mus musculus AKR7A2 MGD MGI:107796
Others AKR7A2 NCBI