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Cat. No.: HY-123118

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NU-7031

NU-7031 (compound 10), a coumarin derivative, is a DNA-PK inhibitor with an IC₅₀ of 1.7 μM. NU-7031 can be used for the study of cancer.

For research use only. We do not sell to patients.

CAS No.: 79105-88-7
Formula: C₁₄H₁₅NO₄
Molecular Weight:261.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

NU-7031 Chemical Structure

CAS No.: 79105-88-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

NU-7031 (compound 10), a coumarin derivative, is a DNA-PK inhibitor with an IC₅₀ of 1.7 μM. NU-7031 can be used for the study of cancer^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	1.75 μM Compound: 64	Inhibition of DNA dependent protein kinase isolated from HeLa cells Inhibition of DNA dependent protein kinase isolated from HeLa cells	[PMID: 15658870]

Chemical Information

CAS No. 79105-88-7
Molecular Weight 261.28
Formula C₁₄H₁₅NO₄
SMILES

O=C1OC=2C=CC(OC)=CC2C(=C1)N3CCOCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Payne SL, et al. Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3649-53. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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