U-46619
Based on 16 publication(s) in Google Scholar
U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation.
For research use only. We do not sell to patients.
- Purity : 99.61%
- CAS No.: 56985-40-1
- Formula: C21H34O4
- Molecular Weight:350.49
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) U-46619
More- Int J Biol Macromol. 2025 Jun;311(Pt 3):144068. [Abstract]
- Int J Mol Med. 2025 Dec;56(6):228. [Abstract]
- Free Radic Biol Med. 2024 Nov 20:225:333-345. [Abstract]
- Cell Rep. 2025 Nov 25;44(11):116505. [Abstract]
- J Ethnopharmacol. 2025 Mar 26:344:119564. [Abstract]
- J Agric Food Chem. 2022 Jan 26;70(3):785-793. [Abstract]
- Biochem Pharmacol. 2025 Oct:240:117107. [Abstract]
- Neurobiol Dis. 2026 Jun 1:223:107390. [Abstract]
- Eur J Pharmacol. 2025 Sep 5:1002:177807. [Abstract]
- Mol Neurobiol. 2025 Jan;62(1):366-385. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Oct;1870(7):167437. [Abstract]
- Stem Cell Rev Rep. 2026 Jan 30;22(3):1325-1340.
- Mol Nutr Food Res. 2022 Jul;66(13):e2200166. [Abstract]
- Int J Chron Obstruct Pulmon Dis. 2024 Jul 8:19:1591-1601. [Abstract]
- J Appl Physiol (1985). 2026 Jan 30. [Abstract]
- J Cancer Res Clin Oncol. 2024 Sep 19;150(9):424. [Abstract]
Customer Validation & Images
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Biological Activity
Description
IC50 & Target
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TXA2/TP |
In Vitro
U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively[1].
U-46619 (10 nM-10 μM) increases internal Ca2+ concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency[1].
U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets[1].
U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:12-15 weeks-old male and female SHR[2]
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Dosage:5 μg/kg
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Administration:Intravenous injection
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Result:Induceed a significant increase of MABP after 1 min in male SHR.
Chemical Information
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CAS No. 56985-40-1
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Appearance Liquid
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Molecular Weight 350.49
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Formula C21H34O4
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Color Colorless to light yellow
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SMILES
O=C(O)CCC/C=C\C[C@H]1[C@@]2([H])CO[C@@](C2)([H])[C@@H]1/C=C/[C@@H](O)CCCCC
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Synonyms
9,11-Methanoepoxy PGH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Publications (16)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
FKBP5 inhibitor suppresses platelet activation and thrombosis by inhibiting IKBKE/PI3K/Rap1 pathway. [Abstract]2025 Jun;311(Pt 3):144068. PMID: 40345291 -
Int J Mol Med
2025 Dec;56(6):228. PMID: 41133478
U-46619 purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2025 Dec;56(6):228. [Abstract]
The expression of autophagy-related proteins in colorectal cancer cells after the addition of the MAPK/ERK pathway activator U-46619 (2 μM) was detected by Western blotting.
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Free Radic Biol Med
Inhibition of acid-sensing receptor GPR4 attenuates neuronal ferroptosis via RhoA/YAP signaling in a rat model of subarachnoid hemorrhage. [Abstract]2024 Nov 20:225:333-345. PMID: 39393553
U-46619 purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Nov 20:225:333-345. [Abstract]
U-46619 (0.1 μg/kg). Representative protein blot band.
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Cell Rep
Tunneling nanotube-mediated stem cell immunomodulation dysfunction promotes adipose inflammation and insulin resistance in GDM. [Abstract]2025 Nov 25;44(11):116505. PMID: 41187060
U-46619 purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Nov 25;44(11):116505. [Abstract]
Adding the RhoA activator U46619 (0.1 μM; 24 h) can partially restore the effect of Wnt5a knockdown on downstream RhoA and Rock1 phosphorylation.
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J Ethnopharmacol
2025 Mar 26:344:119564. PMID: 40015536
U-46619 purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 Mar 26:344:119564. [Abstract]
Washed human platelets were pretreated with different doses of IsA or solvent in the presence of 1 mM CaCl₂, followed by stimulation with thrombin (0.04 U/mL), collagen (1 μg/mL), and U46619 (0.3 μM). ADP (2 μM)-induced aggregation was performed using platelet-rich plasma.
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J Agric Food Chem
Novel Peptide Motifs Containing Asp-Glu-Gly Target P2Y12 and Thromboxane A2 Receptors to Inhibit Platelet Aggregation and Thrombus Formation. [Abstract]2022 Jan 26;70(3):785-793. PMID: 35016500 -
Biochem Pharmacol
2025 Oct:240:117107. PMID: 40619010
U-46619 purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2025 Oct:240:117107. [Abstract]
The summary shows concentration-dependent post-relaxation contraction induced by U46619 (1–1000 nmol/L) in TRPV4fl/fl and TRPV4SMCki/ki mouse aorta.
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Neurobiol Dis
Aquaporin 4 knockdown alleviates traumatic brain edema and reduces neuronal axonal growth cone collapse via the RhoA/ROCK pathway. [Abstract]2026 Jun 1:223:107390. PMID: 41967652 -
Eur J Pharmacol
Morin ameliorates coronary artery relaxation by activating TRPV4-eNOS-NO signalling in high-salt diet-fed rats. [Abstract]2025 Sep 5:1002:177807. PMID: 40472987 -
Mol Neurobiol
Gastrodin Ameliorates Post-Stroke Depressive-Like Behaviors Through Cannabinoid-1 Receptor-Dependent PKA/RhoA Signaling Pathway. [Abstract]2025 Jan;62(1):366-385. PMID: 38856794 -
Biochim Biophys Acta Mol Basis Dis
Methylglyoxal induces endothelial cell apoptosis and coronary microvascular dysfunction through regulating AR-cPLA2 signaling. [Abstract]2024 Oct;1870(7):167437. PMID: 39067539 -
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Mol Nutr Food Res
A Collagen-Derived Oligopeptide from Salmo salar Collagen Hydrolysates Restrains Atherogenesis in ApoE-/- Mice via Targeting P2 Y12 Receptor. [Abstract]2022 Jul;66(13):e2200166. PMID: 35490399 -
Int J Chron Obstruct Pulmon Dis
Exercise Attenuate Diaphragm Atrophy in COPD Mice via Inhibiting the RhoA/ROCK Signaling. [Abstract]2024 Jul 8:19:1591-1601. PMID: 39005647 -
J Appl Physiol (1985)
Attenuated cyclooxygenase-mediated vasodilation in cutaneous microvasculature with no difference in platelet aggregation in women with endometriosis. [Abstract]2026 Jan 30. PMID: 41615377 -
J Cancer Res Clin Oncol
MYO3B promotes cancer progression in endometrial cancer by mediating the calcium ion-RhoA/ROCK1 signaling pathway. [Abstract]2024 Sep 19;150(9):424. PMID: 39297944
Purity & Documentation
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Data Sheet (276 KB)
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SDS (605 KB)
- English - EN (605 KB)
- Français - FR (605 KB)
- Deutsch - DE (605 KB)
- Norwegian - NO (605 KB)
- Español - ES (605 KB)
- Swedish - SV (605 KB)
- Italian - IT (605 KB)
- Korean - KR (605 KB)
- Portuguese - PT (605 KB)
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Handling Instructions (2659 KB)
References
[1]. Ohkubo S, et al. Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets. Br J Pharmacol. 1996 Mar;117(6):1095-104. [Content Brief]
[2]. Su L, et al. The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Stem Cell Res Ther. 2018 Nov 15;9(1):313. [Content Brief]
[3]. Schirner M, et al. U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR). Prostaglandins Leukot Essent Fatty Acids. 1993 Jun;48(6):469-73. [Content Brief]
[4]. Chen S, et al. Roles of the RhoA-ROCK Signaling Pathway in the Endothelial H2S Production and Vasodilation in Rat Cerebral Arteries. ACS Omega. 2022 May 20;7(22):18498-18508. [Content Brief]
[5]. Nie D, et al. Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho. Cancer Res. 2008 Jan 1;68(1):115-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
U-46619 Related Classifications
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