UAMC-4821
Based on 1 Customer Validation
UAMC-4821 is an inhibitor for ferroptosis with an IC50 of 5.2 nM. UAMC-4821 scavenges free radicals, blocks the lipid peroxidation, inhibits ML162 (HY-100002)-induced ferroptosis, and exhibits protective effect in HT-1080 cell. UAMC-4821 exhibits good pharmacokinetics characteristics in mouse with an oral bioavailability of 63%. UAMC-4821 can cross blood-brain barrier.
For research use only. We do not sell to patients.
- Purity: 98.01%
- Formula: C15H19N3O
- Molecular Weight:257.33
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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CNS-Penetrant Compound Library
HY-L028
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Ferroptosis Compound Library
HY-L051
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Neurodegenerative Disease-related Compound Library
HY-L086
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Cell Death Library
HY-L162
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 257.33
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Formula C15H19N3O
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Color White to off-white
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SMILES
NC1=CC(C2=CN=CO2)=CC=C1NC3CCCCC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (194.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8861 mL | 19.4303 mL | 38.8606 mL | 97.1515 mL |
| 5 mM | 0.7772 mL | 3.8861 mL | 7.7721 mL | 19.4303 mL | |
| 10 mM | 0.3886 mL | 1.9430 mL | 3.8861 mL | 9.7152 mL | |
| 15 mM | 0.2591 mL | 1.2954 mL | 2.5907 mL | 6.4768 mL | |
| 20 mM | 0.1943 mL | 0.9715 mL | 1.9430 mL | 4.8576 mL | |
| 25 mM | 0.1554 mL | 0.7772 mL | 1.5544 mL | 3.8861 mL | |
| 30 mM | 0.1295 mL | 0.6477 mL | 1.2954 mL | 3.2384 mL | |
| 40 mM | 0.0972 mL | 0.4858 mL | 0.9715 mL | 2.4288 mL | |
| 50 mM | 0.0777 mL | 0.3886 mL | 0.7772 mL | 1.9430 mL | |
| 60 mM | 0.0648 mL | 0.3238 mL | 0.6477 mL | 1.6192 mL | |
| 80 mM | 0.0486 mL | 0.2429 mL | 0.4858 mL | 1.2144 mL | |
| 100 mM | 0.0389 mL | 0.1943 mL | 0.3886 mL | 0.9715 mL |
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